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Volumn 21, Issue 5, 2014, Pages 597-604

Discerning mild cognitive impairmentand alzheimer diseasefrom normal aging: Morphologic characterization based on univariate and multivariate models

Author keywords

Alzheimer disease; Brain morphology; Healthy aging; Mild cognitive impairment; Structural neuroimaging

Indexed keywords

AGED; AGING; ALZHEIMER DISEASE; ARTICLE; CROSS-SECTIONAL STUDY; FEMALE; FOLLOW UP; HEMISPHERE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; MILD COGNITIVE IMPAIRMENT; MINI MENTAL STATE EXAMINATION; NEUROIMAGING; PRIORITY JOURNAL; TEMPORAL LOBE; THICKNESS; WHITE MATTER; ALGORITHM; AUTOMATED PATTERN RECOGNITION; BRAIN; COMPLICATION; COMPUTER ASSISTED DIAGNOSIS; COMPUTER SIMULATION; DIFFERENTIAL DIAGNOSIS; MULTIVARIATE ANALYSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PROCEDURES; REFERENCE VALUE; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; STATISTICAL MODEL;

EID: 84897558049     PISSN: 10766332     EISSN: 18784046     Source Type: Journal    
DOI: 10.1016/j.acra.2013.12.001     Document Type: Article
Times cited : (8)

References (49)
  • 1
    • 84858225391 scopus 로고    scopus 로고
    • 2012 Alzheimer's disease facts and figures
    • Alzheimer's Association
    • 2012 Alzheimer's disease facts and figures. Alzheimers Dement 2012, 8:131-168. Alzheimer's Association.
    • (2012) Alzheimers Dement , vol.8 , pp. 131-168
  • 3
    • 84871922914 scopus 로고    scopus 로고
    • Preclinical Alzheimer disease - the challenges ahead
    • Sperling R.A., Karlawish J., Johnson K.A. Preclinical Alzheimer disease - the challenges ahead. Nat Rev Neurol 2013, 9:54-58.
    • (2013) Nat Rev Neurol , vol.9 , pp. 54-58
    • Sperling, R.A.1    Karlawish, J.2    Johnson, K.A.3
  • 4
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
    • McKhann G., Drachman D., Folstein M., et al. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984, 34:939-944.
    • (1984) Neurology , vol.34 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3
  • 5
    • 84870469320 scopus 로고    scopus 로고
    • American Psychiatric Association, American Psychiatric Press, Washington DC
    • Diagnostic and statistical manual of mental disorders (DSM-IV-TR) 2000, 147-151. American Psychiatric Association, American Psychiatric Press, Washington DC. 4th ed. - text revised.
    • (2000) Diagnostic and statistical manual of mental disorders (DSM-IV-TR) , pp. 147-151
  • 6
    • 84858113047 scopus 로고    scopus 로고
    • Age and diagnostic performance of Alzheimer disease CSF biomarkers
    • Mattsson N., Rosen E., Hansson O., et al. Age and diagnostic performance of Alzheimer disease CSF biomarkers. Neurology 2012, 78:468-476.
    • (2012) Neurology , vol.78 , pp. 468-476
    • Mattsson, N.1    Rosen, E.2    Hansson, O.3
  • 7
    • 84855304100 scopus 로고    scopus 로고
    • Cerebrospinal fluid levels of beta-amyloid 1-42, but not of tau, are fully changed already 5 to 10 years before the onset of Alzheimer dementia
    • Buchhave P., Minthon L., Zetterberg H., et al. Cerebrospinal fluid levels of beta-amyloid 1-42, but not of tau, are fully changed already 5 to 10 years before the onset of Alzheimer dementia. Arch Gen Psychiatry 2012, 69:98-106.
    • (2012) Arch Gen Psychiatry , vol.69 , pp. 98-106
    • Buchhave, P.1    Minthon, L.2    Zetterberg, H.3
  • 8
    • 0037319171 scopus 로고    scopus 로고
    • Dynamics of gray matter loss in Alzheimer's disease
    • Thompson P.M., Hayashi K.M., de Zubicaray G., et al. Dynamics of gray matter loss in Alzheimer's disease. J Neurosci 2003, 23:994-1005.
    • (2003) J Neurosci , vol.23 , pp. 994-1005
    • Thompson, P.M.1    Hayashi, K.M.2    de Zubicaray, G.3
  • 9
    • 34047202247 scopus 로고    scopus 로고
    • Hippocampal and entorhinal atrophy in mild cognitive impairment: prediction of Alzheimer disease
    • Devanand D.P., Pradhaban G., Liu X., et al. Hippocampal and entorhinal atrophy in mild cognitive impairment: prediction of Alzheimer disease. Neurology 2007, 68:828-836.
    • (2007) Neurology , vol.68 , pp. 828-836
    • Devanand, D.P.1    Pradhaban, G.2    Liu, X.3
  • 10
    • 64949166661 scopus 로고    scopus 로고
    • Alzheimer disease: quantitative structural neuroimaging for detection and prediction of clinical and structural changes in mild cognitive impairment
    • McEvoy L.K., Fennema-Notestine C., Roddey J.C., et al. Alzheimer disease: quantitative structural neuroimaging for detection and prediction of clinical and structural changes in mild cognitive impairment. Radiology 2009, 251:195-205.
    • (2009) Radiology , vol.251 , pp. 195-205
    • McEvoy, L.K.1    Fennema-Notestine, C.2    Roddey, J.C.3
  • 11
    • 58149386194 scopus 로고    scopus 로고
    • Baseline and longitudinal patterns of brain atrophy in MCI patients, and their use in prediction of short-term conversion to AD: results from ADNI
    • Misra C., Fan Y., Davatzikos C. Baseline and longitudinal patterns of brain atrophy in MCI patients, and their use in prediction of short-term conversion to AD: results from ADNI. Neuroimage 2009, 44:1415-1422.
    • (2009) Neuroimage , vol.44 , pp. 1415-1422
    • Misra, C.1    Fan, Y.2    Davatzikos, C.3
  • 12
    • 77952879255 scopus 로고    scopus 로고
    • Automated cross-sectional and longitudinal hippocampal volume measurement in mild cognitive impairment and Alzheimer's disease
    • Leung K.K., Barnes J., Ridgway G.R., et al. Automated cross-sectional and longitudinal hippocampal volume measurement in mild cognitive impairment and Alzheimer's disease. Neuroimage 2010, 51:1345-1359.
    • (2010) Neuroimage , vol.51 , pp. 1345-1359
    • Leung, K.K.1    Barnes, J.2    Ridgway, G.R.3
  • 13
    • 43249084924 scopus 로고    scopus 로고
    • Magnetic resonance imaging characterization of brain structure and function in mild cognitive impairment: a review
    • Ries M.L., Carlsson C.M., Rowley H.A., et al. Magnetic resonance imaging characterization of brain structure and function in mild cognitive impairment: a review. J Am Geriatr Soc 2008, 56:920-934.
    • (2008) J Am Geriatr Soc , vol.56 , pp. 920-934
    • Ries, M.L.1    Carlsson, C.M.2    Rowley, H.A.3
  • 14
    • 79958054907 scopus 로고    scopus 로고
    • Functional impairment in elderly patients with mild cognitive impairment and mild Alzheimer disease
    • Brown P.J., Devanand D.P., Liu X., et al. Functional impairment in elderly patients with mild cognitive impairment and mild Alzheimer disease. Arch Gen Psychiatry 2011, 68:617-626.
    • (2011) Arch Gen Psychiatry , vol.68 , pp. 617-626
    • Brown, P.J.1    Devanand, D.P.2    Liu, X.3
  • 15
    • 82755196258 scopus 로고    scopus 로고
    • Relationship between regional atrophy rates and cognitive decline in mild cognitive impairment
    • McDonald C.R., Gharapetian L., McEvoy L.K., et al. Relationship between regional atrophy rates and cognitive decline in mild cognitive impairment. Neurobiol Aging 2012, 33:242-253.
    • (2012) Neurobiol Aging , vol.33 , pp. 242-253
    • McDonald, C.R.1    Gharapetian, L.2    McEvoy, L.K.3
  • 16
    • 70350061949 scopus 로고    scopus 로고
    • Multi-modal techniques for diagnosis and prognosis of Alzheimer's disease
    • Perrin R.J., Fagan A.M., Holtzman D.M. Multi-modal techniques for diagnosis and prognosis of Alzheimer's disease. Nature 2009, 461:916-922.
    • (2009) Nature , vol.461 , pp. 916-922
    • Perrin, R.J.1    Fagan, A.M.2    Holtzman, D.M.3
  • 17
    • 0033933649 scopus 로고    scopus 로고
    • Voxel-based morphometry - the methods
    • Ashburner J., Friston K.J. Voxel-based morphometry - the methods. Neuroimage 2000, 11:805-821.
    • (2000) Neuroimage , vol.11 , pp. 805-821
    • Ashburner, J.1    Friston, K.J.2
  • 18
    • 67749118071 scopus 로고    scopus 로고
    • Early diagnosis of Alzheimer's disease using cortical thickness: impact of cognitive reserve
    • Querbes O., Aubry F., Pariente J., et al. Early diagnosis of Alzheimer's disease using cortical thickness: impact of cognitive reserve. Brain 2009, 132:2036-2047.
    • (2009) Brain , vol.132 , pp. 2036-2047
    • Querbes, O.1    Aubry, F.2    Pariente, J.3
  • 19
    • 37849018688 scopus 로고    scopus 로고
    • Relationship among neuroimaging indices of cerebral health during normal aging
    • Kochunov P., Thompson P.M., Coyle T.R., et al. Relationship among neuroimaging indices of cerebral health during normal aging. Hum Brain Mapp 2008, 29:36-45.
    • (2008) Hum Brain Mapp , vol.29 , pp. 36-45
    • Kochunov, P.1    Thompson, P.M.2    Coyle, T.R.3
  • 20
    • 70350635395 scopus 로고    scopus 로고
    • Hippocampal volume and asymmetry in mild cognitive impairment and Alzheimer's disease: Meta-analyses of MRI studies
    • Shi F., Liu B., Zhou Y., et al. Hippocampal volume and asymmetry in mild cognitive impairment and Alzheimer's disease: Meta-analyses of MRI studies. Hippocampus 2009, 19:1055-1064.
    • (2009) Hippocampus , vol.19 , pp. 1055-1064
    • Shi, F.1    Liu, B.2    Zhou, Y.3
  • 21
    • 52249108910 scopus 로고    scopus 로고
    • Sulcal morphology changes and their relationship with cortical thickness and gyral white matter volume in mild cognitive impairment and Alzheimer's disease
    • Im K., Lee J.M., Seo S.W., et al. Sulcal morphology changes and their relationship with cortical thickness and gyral white matter volume in mild cognitive impairment and Alzheimer's disease. Neuroimage 2008, 43:103-113.
    • (2008) Neuroimage , vol.43 , pp. 103-113
    • Im, K.1    Lee, J.M.2    Seo, S.W.3
  • 22
    • 0027425211 scopus 로고
    • The Clinical Dementia Rating (CDR): current version and scoring rules
    • Morris J.C. The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology 1993, 43:2412-2414.
    • (1993) Neurology , vol.43 , pp. 2412-2414
    • Morris, J.C.1
  • 23
    • 0027288853 scopus 로고
    • Mini-Mental State Examination. Norms, normals, and numbers
    • Cummings J.L. Mini-Mental State Examination. Norms, normals, and numbers. JAMA 1993, 269:2420-2421.
    • (1993) JAMA , vol.269 , pp. 2420-2421
    • Cummings, J.L.1
  • 24
    • 41949137974 scopus 로고    scopus 로고
    • The Alzheimer's disease neuroimaging initiative (ADNI): MRI methods
    • Jack C.R., Bernstein M.A., Fox N.C., et al. The Alzheimer's disease neuroimaging initiative (ADNI): MRI methods. J Magn Reson Imaging 2008, 27:685-691.
    • (2008) J Magn Reson Imaging , vol.27 , pp. 685-691
    • Jack, C.R.1    Bernstein, M.A.2    Fox, N.C.3
  • 25
    • 9144254529 scopus 로고    scopus 로고
    • Automatically parcellating the human cerebral cortex
    • Fischl B., van der Kouwe A., Destrieux C., et al. Automatically parcellating the human cerebral cortex. Cereb Cortex 2004, 14:11-22.
    • (2004) Cereb Cortex , vol.14 , pp. 11-22
    • Fischl, B.1    van der Kouwe, A.2    Destrieux, C.3
  • 26
    • 33746932485 scopus 로고    scopus 로고
    • An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest
    • Desikan R.S., Segonne F., Fischl B., et al. An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. Neuroimage 2006, 31:968-980.
    • (2006) Neuroimage , vol.31 , pp. 968-980
    • Desikan, R.S.1    Segonne, F.2    Fischl, B.3
  • 27
    • 84886255781 scopus 로고    scopus 로고
    • Distinct laterality alterations distinguish mild cognitive impairment and Alzheimer's disease from healthy aging: statistical parametric mapping with high resolution MRI
    • Long X., Zhang L., Liao W., et al. Distinct laterality alterations distinguish mild cognitive impairment and Alzheimer's disease from healthy aging: statistical parametric mapping with high resolution MRI. Hum Brain Mapp 2013, 34:3400-3410.
    • (2013) Hum Brain Mapp , vol.34 , pp. 3400-3410
    • Long, X.1    Zhang, L.2    Liao, W.3
  • 28
    • 0032769093 scopus 로고    scopus 로고
    • Cortical surface-based analysis. I. Segmentation and surface reconstruction
    • Dale A.M., Fischl B., Sereno M.I. Cortical surface-based analysis. I. Segmentation and surface reconstruction. Neuroimage 1999, 9:179-194.
    • (1999) Neuroimage , vol.9 , pp. 179-194
    • Dale, A.M.1    Fischl, B.2    Sereno, M.I.3
  • 29
    • 0032799993 scopus 로고    scopus 로고
    • Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system
    • Fischl B., Sereno M., Dale A. Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system. Neuroimage 1999, 9:195-207.
    • (1999) Neuroimage , vol.9 , pp. 195-207
    • Fischl, B.1    Sereno, M.2    Dale, A.3
  • 30
    • 0034718613 scopus 로고    scopus 로고
    • Measuring the thickness of the human cerebral cortex from magnetic resonance images
    • Fischl B., Dale A.M. Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proc Natl Acad Sci U S A 2000, 97:11050-11055.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 11050-11055
    • Fischl, B.1    Dale, A.M.2
  • 31
    • 84862506498 scopus 로고    scopus 로고
    • Healthy aging: an automatic analysis of global and regional morphological alterations of human brain
    • Long X., Liao W., Jiang C., et al. Healthy aging: an automatic analysis of global and regional morphological alterations of human brain. Acad Radiol 2012, 19:785-793.
    • (2012) Acad Radiol , vol.19 , pp. 785-793
    • Long, X.1    Liao, W.2    Jiang, C.3
  • 32
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: a practical and powerful approach to multiple testing
    • Benjamini Y., Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Ser B Methodol 1995, 57:289-300.
    • (1995) J R Stat Soc Ser B Methodol , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 33
    • 77952310047 scopus 로고    scopus 로고
    • Volume changes in Alzheimer's disease and mild cognitive impairment: cognitive associations
    • Evans M.C., Barnes J., Nielsen C., et al. Volume changes in Alzheimer's disease and mild cognitive impairment: cognitive associations. Eur Radiol 2010, 20:674-682.
    • (2010) Eur Radiol , vol.20 , pp. 674-682
    • Evans, M.C.1    Barnes, J.2    Nielsen, C.3
  • 34
    • 50849121987 scopus 로고    scopus 로고
    • Ventricular enlargement as a possible measure of Alzheimer's disease progression validated using the Alzheimer's disease neuroimaging initiative database
    • Nestor S.M., Rupsingh R., Borrie M., et al. Ventricular enlargement as a possible measure of Alzheimer's disease progression validated using the Alzheimer's disease neuroimaging initiative database. Brain 2008, 131:2443-2454.
    • (2008) Brain , vol.131 , pp. 2443-2454
    • Nestor, S.M.1    Rupsingh, R.2    Borrie, M.3
  • 35
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimer-related changes
    • Braak H., Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 1991, 82:239-259.
    • (1991) Acta Neuropathol , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 36
    • 84857419176 scopus 로고    scopus 로고
    • MRI cortical thickness biomarker predicts AD-like CSF and cognitive decline in normal adults
    • Dickerson B.C., Wolk D.A. MRI cortical thickness biomarker predicts AD-like CSF and cognitive decline in normal adults. Neurology 2012, 78:84-90.
    • (2012) Neurology , vol.78 , pp. 84-90
    • Dickerson, B.C.1    Wolk, D.A.2
  • 37
    • 80054959328 scopus 로고    scopus 로고
    • Neurochemical alterations of the entorhinal cortex in amnestic mild cognitive impairment (aMCI): a three-year follow-up study
    • Seo S.W., Lee J.H., Jang S.M., et al. Neurochemical alterations of the entorhinal cortex in amnestic mild cognitive impairment (aMCI): a three-year follow-up study. Arch Gerontol Geriatr 2012, 54:192-196.
    • (2012) Arch Gerontol Geriatr , vol.54 , pp. 192-196
    • Seo, S.W.1    Lee, J.H.2    Jang, S.M.3
  • 38
    • 77956277498 scopus 로고    scopus 로고
    • Hippocampal atrophy patterns in mild cognitive impairment and Alzheimer's disease
    • Mueller S.G., Schuff N., Yaffe K., et al. Hippocampal atrophy patterns in mild cognitive impairment and Alzheimer's disease. Hum Brain Mapp 2010, 31:1339-1347.
    • (2010) Hum Brain Mapp , vol.31 , pp. 1339-1347
    • Mueller, S.G.1    Schuff, N.2    Yaffe, K.3
  • 39
    • 0141631756 scopus 로고    scopus 로고
    • Morphology of the inner structure of the hippocampal formation in Alzheimer disease
    • Adachi M., Kawakatsu S., Hosoya T., et al. Morphology of the inner structure of the hippocampal formation in Alzheimer disease. AJNR Am J Neuroradiol 2003, 24:1575-1581.
    • (2003) AJNR Am J Neuroradiol , vol.24 , pp. 1575-1581
    • Adachi, M.1    Kawakatsu, S.2    Hosoya, T.3
  • 40
    • 80053383653 scopus 로고    scopus 로고
    • Amygdala atrophy is prominent in early Alzheimer's disease and relates to symptom severity
    • Poulin S.P., Dautoff R., Morris J.C., et al. Amygdala atrophy is prominent in early Alzheimer's disease and relates to symptom severity. Psychiatry Res 2011, 194:7-13.
    • (2011) Psychiatry Res , vol.194 , pp. 7-13
    • Poulin, S.P.1    Dautoff, R.2    Morris, J.C.3
  • 41
    • 77957299007 scopus 로고    scopus 로고
    • Six-month atrophy in MTL structures is associated with subsequent memory decline in elderly controls
    • Murphy E.A., Holland D., Donohue M., et al. Six-month atrophy in MTL structures is associated with subsequent memory decline in elderly controls. Neuroimage 2010, 53:1310-1317.
    • (2010) Neuroimage , vol.53 , pp. 1310-1317
    • Murphy, E.A.1    Holland, D.2    Donohue, M.3
  • 42
    • 79953865830 scopus 로고    scopus 로고
    • Minimal atrophy of the entorhinal cortex and hippocampus: progression of cognitive impairment
    • Varon D., Loewenstein D.A., Potter E., et al. Minimal atrophy of the entorhinal cortex and hippocampus: progression of cognitive impairment. Dement Geriatr Cogn Disord 2011, 31:276-283.
    • (2011) Dement Geriatr Cogn Disord , vol.31 , pp. 276-283
    • Varon, D.1    Loewenstein, D.A.2    Potter, E.3
  • 43
    • 27744479697 scopus 로고    scopus 로고
    • Age-related morphology trends of cortical sulci
    • Kochunov P., Mangin J.F., Coyle T., et al. Age-related morphology trends of cortical sulci. Hum Brain Mapp 2005, 26:210-220.
    • (2005) Hum Brain Mapp , vol.26 , pp. 210-220
    • Kochunov, P.1    Mangin, J.F.2    Coyle, T.3
  • 44
    • 82755161873 scopus 로고    scopus 로고
    • Discriminant analysis of longitudinal cortical thickness changes in Alzheimer's disease using dynamic and network features
    • Li Y., Wang Y., Wu G., et al. Discriminant analysis of longitudinal cortical thickness changes in Alzheimer's disease using dynamic and network features. Neurobiol Aging 2012, 33:415-427.
    • (2012) Neurobiol Aging , vol.33 , pp. 415-427
    • Li, Y.1    Wang, Y.2    Wu, G.3
  • 45
    • 77955309565 scopus 로고    scopus 로고
    • Longitudinal changes in medial temporal cortical thickness in normal subjects with the APOE-4 polymorphism
    • Donix M., Burggren A.C., Suthana N.A., et al. Longitudinal changes in medial temporal cortical thickness in normal subjects with the APOE-4 polymorphism. Neuroimage 2010, 53:37-43.
    • (2010) Neuroimage , vol.53 , pp. 37-43
    • Donix, M.1    Burggren, A.C.2    Suthana, N.A.3
  • 46
    • 58149200530 scopus 로고    scopus 로고
    • Brain size and folding of the human cerebral cortex
    • Toro R., Perron M., Pike B., et al. Brain size and folding of the human cerebral cortex. Cereb Cortex 2008, 18:2352-2357.
    • (2008) Cereb Cortex , vol.18 , pp. 2352-2357
    • Toro, R.1    Perron, M.2    Pike, B.3
  • 47
    • 47649113138 scopus 로고    scopus 로고
    • Cortical folding patterns and predicting cytoarchitecture
    • Fischl B., Rajendran N., Busa E., et al. Cortical folding patterns and predicting cytoarchitecture. Cereb Cortex 2008, 18:1973-1980.
    • (2008) Cereb Cortex , vol.18 , pp. 1973-1980
    • Fischl, B.1    Rajendran, N.2    Busa, E.3
  • 48
    • 79951722994 scopus 로고    scopus 로고
    • Early-onset versus late-onset Alzheimer's disease: the case of the missing APOE varepsilon4 allele
    • van der Flier W.M., Pijnenburg Y.A., Fox N.C., et al. Early-onset versus late-onset Alzheimer's disease: the case of the missing APOE varepsilon4 allele. Lancet Neurol 2011, 10:280-288.
    • (2011) Lancet Neurol , vol.10 , pp. 280-288
    • van der Flier, W.M.1    Pijnenburg, Y.A.2    Fox, N.C.3
  • 49
    • 77950349494 scopus 로고    scopus 로고
    • Early-versus late-onset Alzheimer's disease: more than age alone
    • Koedam E.L., Lauffer V., van der Vlies A.E., et al. Early-versus late-onset Alzheimer's disease: more than age alone. J Alzheimers Dis 2010, 19:1401-1408.
    • (2010) J Alzheimers Dis , vol.19 , pp. 1401-1408
    • Koedam, E.L.1    Lauffer, V.2    van der Vlies, A.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.