Pro-inflammatory chemokine CCL2 (MCP-1) promotes healing in diabetic wounds by restoring the macrophage response

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Wood, Stephen ^a   Jayaraman, Vijayakumar ^a   Huelsmann, Erica J ^a   Bonish, Brian ^a   Burgad, Derick ^a   Sivaramakrishnan, Gayathri ^a   Qin, Shanshan ^a   DiPietro, Luisa A ^b   Zloza, Andrew ^a   Zhang, Chunxiang ^a   Shafikhani, Sasha H ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; MONOCYTE CHEMOTACTIC PROTEIN 1; RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; DIABETIC WOUND; FLOW CYTOMETRY; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; IMMUNOCOMPETENT CELL; MACROPHAGE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; SKIN; WOUND; WOUND HEALING; ANIMAL; DIABETES MELLITUS; DISEASE MODEL; DRUG EFFECTS; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY;

ANIMALS; CHEMOKINE CCL2; DIABETES COMPLICATIONS; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; MACROPHAGES; MICE; MICE, KNOCKOUT; SKIN; WOUND HEALING;

EID: 84897549831     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0091574     Document Type: Article

References (41)

1. Singer AJ, Clark RA (1999) Cutaneous wound healing. N Engl J Med 341: 738-746. (Pubitemid 29407375)
2. Bjarnsholt T, Kirketerp-Moller K, Jensen PO, Madsen KG, Phipps R, et al. (2008) Why chronic wounds will not heal: a novel hypothesis. Wound Repair Regen 16: 2-10.
3. Donath MY, Shoelson SE (2011) Type 2 diabetes as an inflammatory disease. Nat Rev Immunol 11: 98-107.
4. Shaw TJ, Martin P (2009) Wound repair at a glance. J Cell Sci 122: 3209-3213.
5. Adzick NS, Harrison MR, Glick PL, Beckstead JH, Villa RL, et al. (1985) Comparison of fetal, newborn, and adult wound healing by histologic, enzymehistochemical, and hydroxyproline determinations. J Pediatr Surg 20: 315-319. (Pubitemid 15227574)
6. Martin P, D'Souza D, Martin J, Grose R, Cooper L, et al. (2003) Wound healing in the PU.1 null mouse-tissue repair is not dependent on inflammatory cells. Curr Biol 13: 1122-1128. (Pubitemid 36815260)
7. Leibovich SJ, Ross R (1975) The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum. Am J Pathol 78: 71-100.
8. Lucas T, Waisman A, Ranjan R, Roes J, Krieg T, et al. (2010) Differential roles of macrophages in diverse phases of skin repair. J Immunol 184: 3964-3977.
9. Mirza R, DiPietro LA, Koh TJ (2009) Selective and specific macrophage ablation is detrimental to wound healing in mice. Am J Pathol 175: 2454-2462.
10. Goren I, Allmann N, Yogev N, Schurmann C, Linke A, et al. (2009) A transgenic mouse model of inducible macrophage depletion: effects of diphtheria toxin-driven lysozyme M-specific cell lineage ablation on wound inflammatory, angiogenic, and contractive processes. Am J Pathol 175: 132-147.
11. Maruyama K, Asai J, Ii M, Thorne T, Losordo DW, et al. (2007) Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing. Am J Pathol 170: 1178-1191. (Pubitemid 47339326)
12. Greenhalgh DG, Sprugel KH, Murray MJ, Ross R (1990) PDGF and FGF stimulate wound healing in the genetically diabetic mouse. Am J Pathol 136: 1235-1246. (Pubitemid 20210322)
13. Brown GL, Nanney LB, Griffen J, Cramer AB, Yancey JM, et al. (1989) Enhancement of wound healing by topical treatment with epidermal growth factor. N Engl J Med 321: 76-79. (Pubitemid 19170395)
14. Chen H, Charlat O, Tartaglia LA, Woolf EA, Weng X, et al. (1996) Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 84: 491-495. (Pubitemid 26060722)
15. Farooqi S, O'Rahilly S (2006) Genetics of obesity in humans. Endocrine reviews 27: 710-718.
16. Godwin A (2011) Histochemical Uses Of Haematoxylin - A Review JPCS 1: 24-34.
17. Wetzler C, Kampfer H, Stallmeyer B, Pfeilschifter J, Frank S (2000) Large and sustained induction of chemokines during impaired wound healing in the genetically diabetic mouse: prolonged persistence of neutrophils and macrophages during the late phase of repair. J Invest Dermatol 115: 245-253. (Pubitemid 30637194)
18. Blakytny R, Jude E (2006) The molecular biology of chronic wounds and delayed healing in diabetes. Diabet Med 23: 594-608. (Pubitemid 43830059)
19. Strobl H, Scheinecker C, Csmarits B, Majdic O, Knapp W (1995) Flow cytometric analysis of intracellular CD68 molecule expression in normal and malignant haemopoiesis. Br J Haematol 90: 774-782.
20. Kreipe H, Radzun HJ, Parwaresch MR, Haislip A, Hansmann ML (1987) Ki-M7 monoclonal antibody specific for myelomonocytic cell lineage and macrophages in human. J Histochem Cytochem 35: 1117-1126.
21. Bellavance EC, Kohlhapp FJ, Zloza A, O'Sullivan JA, McCracken J, et al. (2011) Development of tumor-infiltrating CD8+ T cell memory precursor effector cells and antimelanoma memory responses are the result of vaccination and TGF-beta blockade during the perioperative period of tumor resection. J Immunol 186: 3309-3316.
22. Zloza A, Kohlhapp FJ, Lyons GE, Schenkel JM, Moore TV, et al. (2012) NKG2D signaling on CD8(+) T cells represses T-bet and rescues CD4-unhelped CD8(+) T cell memory recall but not effector responses. Nature medicine 18: 422-428.
23. Raman D, Sobolik-Delmaire T, Richmond A (2011) Chemokines in health and disease. Exp Cell Res 317: 575-589.
24. Dipietro LA, Reintjes MG, Low QE, Levi B, Gamelli RL (2001) Modulation of macrophage recruitment into wounds by monocyte chemoattractant protein-1. Wound Repair Regen 9: 28-33. (Pubitemid 32268511)
25. Low QE, Drugea IA, Duffner LA, Quinn DG, Cook DN, et al. (2001) Wound healing in MIP-1alpha(-/-) and MCP-1(-/-) mice. Am J Pathol 159: 457-463. (Pubitemid 32751076)
26. Lu B, Rutledge BJ, Gu L, Fiorillo J, Lukacs NW, et al. (1998) Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice. J Exp Med 187: 601-608. (Pubitemid 28093362)
27. Ishida Y, Gao JL, Murphy PM (2008) Chemokine receptor CX3CR1 mediates skin wound healing by promoting macrophage and fibroblast accumulation and function. J Immunol 180: 569-579.
28. Ikejima S, Sasaki S, Sashinami H, Mori F, Ogawa Y, et al. (2005) Impairment of host resistance to Listeria monocytogenes infection in liver of db/db and ob/ob mice. Diabetes 54: 182-189. (Pubitemid 40105111)
29. Fang Y, Shen J, Yao M, Beagley KW, Hambly BD, et al. (2010) Granulocytemacrophage colony-stimulating factor enhances wound healing in diabetes via upregulation of proinflammatory cytokines. Br J Dermatol 162: 478-486.
30. Dong YL, Fleming RY, Yan TZ, Herndon DN, Waymack JP (1993) Effect of ibuprofen on the inflammatory response to surgical wounds. J Trauma 35: 340-343. (Pubitemid 23292481)
31. Dvivedi S, Tiwari SM, Sharma A (1997) Effect of ibuprofen and diclofenac sodium on experimental would healing. Indian J Exp Biol 35: 1243-1245. (Pubitemid 28011611)
32. Krischak GD, Augat P, Claes L, Kinzl L, Beck A (2007) The effects of nonsteroidal anti-inflammatory drug application on incisional wound healing in rats. J Wound Care 16: 76-78.
33. Beer HD, Longaker MT, Werner S (1997) Reduced expression of PDGF and PDGF receptors during impaired wound healing. J Invest Dermatol 109: 132-138. (Pubitemid 27337325)
34. Menke NB, Ward KR, Witten TM, Bonchev DG, Diegelmann RF (2007) Impaired wound healing. Clin Dermatol 25: 19-25. (Pubitemid 46177472)
35. Wang J, Jiao H, Stewart TL, Lyons MV, Shankowsky HA, et al. (2007) Accelerated wound healing in leukocyte-specific, protein 1-deficient mouse is associated with increased infiltration of leukocytes and fibrocytes. J Leukoc Biol 82: 1554-1563. (Pubitemid 350276967)
36. Kohlhapp FJ, Zloza A, O'Sullivan JA, Moore TV, Lacek AT, et al. (2012) CD8(+) T cells sabotage their own memory potential through IFN-gammadependent modification of the IL-12/IL-15 receptor alpha axis on dendritic cells. J Immunol 188: 3639-3647.
37. Peters NC, Egen JG, Secundino N, Debrabant A, Kimblin N, et al. (2008) In vivo imaging reveals an essential role for neutrophils in leishmaniasis transmitted by sand flies. Science 321: 970-974.
38. Hackstein H, Wachtendorf A, Kranz S, Lohmeyer J, Bein G, et al. (2012) Heterogeneity of respiratory dendritic cell subsets and lymphocyte populations in inbred mouse strains. Respir Res 13: 94.
39. Roupe KM, Nybo M, Sjobring U, Alberius P, Schmidtchen A, et al. (2010) Injury is a major inducer of epidermal innate immune responses during wound healing. J Invest Dermatol 130: 1167-1177.
40. Davies JQ, Gordon S (2005) Isolation and culture of murine macrophages. Methods Mol Biol 290: 91-103.
41. Frevert CW, Wong VA, Goodman RB, Goodwin R, Martin TR (1998) Rapid fluorescence-based measurement of neutrophil migration in vitro. J Immunol Methods 213: 41-52. (Pubitemid 28376594)