The astaxanthin-induced improvement in lipid metabolism during exercise is mediated by a PGC-1α increase in skeletal muscle

Journal of Clinical Biochemistry and Nutrition

Volumn 54, Issue 2, 2014, Pages 86-89

  Liu, Po Hung ^a   Aoi, Wataru ^b   Takami, Maki ^b   Terajima, Hitomi ^b   Tanimura, Yuko ^a   Naito, Yuji ^a   Itoh, Yoshito ^a   Yoshikawa, Toshikazu ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^b KYOTO PREFECTURAL UNIVERSITY   (Japan)

Author keywords

Astaxanthin; Lipid metabolism; PGC 1 ; Running exercise; Skeletal muscle

Indexed keywords

ASTAXANTHIN; FATTY ACID; GLUCOSE; LACTIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA;

AEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD SAMPLING; BODY WEIGHT; CONTROLLED STUDY; DIET; EXERCISE; FATTY ACID BLOOD LEVEL; GLUCOSE BLOOD LEVEL; LACTATE BLOOD LEVEL; LIPID METABOLISM; METABOLIC PARAMETERS; MOUSE; MUSCLE FATIGUE; NONHUMAN; PH; RUNNING; SKELETAL MUSCLE; TREADMILL EXERCISE; TREATMENT DURATION; WESTERN BLOTTING;

EID: 84897546803     PISSN: 09120009     EISSN: None     Source Type: Journal    
DOI: 10.3164/jcbn.13-110     Document Type: Article

References (19)

1. Kuhn R, Soerensen NA. The coloring matters of the lobster (Astacus gammarus L.). Z Angew Chem 1938; 51: 465-466.
2. Miki W. Biological functions and activities of animal carotenoids. Pure Appl Chem 1991; 63: 141-146.
3. Naguib Y. Antioxidant activities of astaxanthin and related carotenoids. J Agric Chem 2000; 48: 1150-1154. (Pubitemid 30243677)
4. Aoi W, Naito Y, Sakuma K, et al. Astaxanthin limits exercise-induced skeletal and cardiac muscle damage in mice. Antioxid Redox Signal 2003; 5: 139-144. (Pubitemid 36337025)
5. Naito Y, Uchiyama K, Aoi W, et al. Prevention of diabetic nephropathy by treatment with astaxanthin in diabetic db/db mice. Biofactors 2004; 20: 49-59. (Pubitemid 38586209)
6. Aoi W, Naito Y, Takanami Y, et al. Astaxanthin improves muscle lipid metabolism in exercise via inhibitory effect of oxidative CPT 1 modification. Biochem Biophys Res Commun 2007; 366: 892-897.
7. Ikeuchi M, Koyama T, Takahashi J, Yazawa K. Effects of astaxanthin supplementation on exercise-induced fatigue in mice. Biol Pharm Bull 2006; 29: 2106-2110. (Pubitemid 44510817)
8. Earnest CP, Lupo M, White KM, Church TS. Effect of astaxanthin on cycling time trial performance. Int J Sports Med 2011; 32: 882-888.
9. Wu Z, Puigserver P, Andersson U, et al. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 1999; 98: 115-124. (Pubitemid 29331201)
10. Olesen J, Kiilerich K, Pilegaard H. PGC-1 alpha-mediated adaptations in skeletal muscle. Pflugers Arch 2010; 460: 153-162.
11. Patti ME, Butte AJ, Crunkhorn S, et al. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc Natl Acad Sci USA 2003; 100: 8466-8471. (Pubitemid 36842568)
12. Calvo JA, Daniels TG, Wang X, et al. Muscle-specific expression of PPAR-gamma coactivator-1 alpha improves exercise performance and increases peak oxygen uptake. J Appl Physiol (1985) 2008; 104: 1304-1312.
13. Wenz T, Rossi SG, Rotundo RL, Spiegelman BM, Moraes CT. Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging. Proc Natl Acad Sci USA 2009; 106: 20405-20410.
14. Brooks GA. The lactate shuttle during exercise and recovery. Med Sci Sports Exerc 1986; 18: 360-368. (Pubitemid 16091670)
15. Robergs RA, Ghiasvand F, Parker D. Biochemistry of exercise-induced metabolic acidosis. Am J Physiol Regul Integr Comp Physiol 2004; 287: R502-R516. (Pubitemid 39095921)
16. Steinhagen C, Hirche HJ, Nestle HW, Bovenkamp U, Hosselmann I. The interstitial pH of the working gastrocnemius muscle of the dog. Pflugers Arch 1976; 367: 151-156. (Pubitemid 8007532)
17. Boström P, Wu J, Jedrychowsk MP, et al. A PGC-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 2012; 481: 463-468.
18. Ristow M, Zarse K, Oberbach A, et al. Antioxidants prevent health-promoting effects of physical exercise in humans. Proc Natl Acad Sci U S A 2009; 106: 8665-8670.
19. Gomez-Cabrera MC, Domenech E, Romagnoli M, et al. Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance. Am J Clin Nutr 2008; 87: 142-149.