Protective effect of ketamine against hemorrhagic cystitis in rats receiving ifosfamide

Indian Journal of Pharmacology

Volumn 46, Issue 2, 2014, Pages 147-151

  Ozguven, Ali A ^a   Yilmaz, Omer ^a   Taneli, Fatma ^a   Ulman, Cevval ^a   Vatansever, Seda ^a   Onag, Ali ^a  

^a CELAL BAYAR UNIVERSITY   (Turkey)

Author keywords

Hemorrhagic cystitis; Ifosfamide; ketamine; mesna; protective

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; IFOSFAMIDE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; KETAMINE; MALONALDEHYDE; MESNA; NITRIC OXIDE; TUMOR NECROSIS FACTOR ALPHA; ALKYLATING AGENT; BIOLOGICAL MARKER;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER INJURY; BLADDER WET WEIGHT; CONTROLLED STUDY; DRUG POTENTIATION; EDEMA; FEMALE; HEMORRHAGIC CYSTITIS; HISTOPATHOLOGY; NONHUMAN; OXIDATIVE STRESS; PREMEDICATION; PROTEIN EXPRESSION; RAT; RENAL PROTECTION; RENAL SYSTEM PARAMETERS; SINGLE DRUG DOSE; VESICAL EDEMA; ANIMAL; BLADDER; CHEMICALLY INDUCED; CYSTITIS; DRUG COMBINATION; DRUG EFFECTS; HEMORRHAGE; IMMUNOHISTOCHEMISTRY; METABOLISM; ORGAN SIZE; PATHOLOGY; TOXICITY; WISTAR RAT;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; BIOLOGICAL MARKERS; CYSTITIS; DRUG THERAPY, COMBINATION; FEMALE; HEMORRHAGE; IFOSFAMIDE; IMMUNOHISTOCHEMISTRY; KETAMINE; MESNA; ORGAN SIZE; OXIDATIVE STRESS; RATS, WISTAR; URINARY BLADDER;

EID: 84897525990     PISSN: 02537613     EISSN: 19983751     Source Type: Journal    
DOI: 10.4103/0253-7613.129301     Document Type: Article

References (23)

1. Batista CK, Mota JM, Souza ML, Leitao BT, Souza MH, Brito GA, et al. Amifostine and glutathione prevent ifosfamide-And acrolein-induced hemorrhagic cystitis. Cancer Chemother Pharmacol 2007;59:71-7
2. Mota JM, Brito GA, Loiola RT, Cunha FQ, Ribeiro Rde A. Interleukin-11 attenuates ifosfamide-induced hemorrhagic cystitis. Int Braz J Urol 2007;33:704-10
3. Skinner R. Chronic ifosfamide nephrotoxicity in children. Med Pediatr Oncol 2003;41:190-7
4. Ratliff TR, Willians RD. Hemorrhagic cystitis, chemotherapy, and bladder toxicity. J Urol 1998;159:1044
5. Vieira MM, Brito GA, Belarmino-Filho JN, Macedo FY, Nery EA, Cunha FQ, et al. Use of dexamethasone with mesna for the prevention of ifosfamide-induced hemorrhagic cystitis. Int J Urol 2003;10:595-602
6. Hirota K, Lambert DG. Ketamine: New uses for an old drug? Br J Anaesth 2011;107:123-6
7. Shaked G, Czeiger D, Dukhno O, Levy I, Artru AA, Shapira Y, et al. Ketamine improves survival and suppresses IL-6 and TNFalpha production in a model of Gram-negative bacterial sepsis in rats. Resuscitation 2004;62:237-42
8. Roytblat L, Talmor D, Rachinsky M, Greemberg L, Pekar A, Appelbaum A, et al. Ketamine attenuates the interleukin-6 response after cardiopulmonary bypass. Anesth Analg 1998;87:266-71
9. Zhu MM, Zhou QH, Zhu MH, Rong HB, Xu YM, Qian YN, et al. Effects of nebulized ketamine on allergen-induced airway hyperresponsiveness and inflammation in actively sensitized Brown-Norway rats. J Inflamm (Lond) 2007;4:10
10. Gray KJ, Engelmann UH, Johnson EH, Fishman IJ. Evaluation of misoprostol cytoprotection of the bladder with cyclophosphamide (Cytoxan) therapy. J Urol 1986;133:497-500
11. Cortas NK, Wakid NW. Determination of inorganic nitrate in serum and urine by a kinetic cadmium-reduction method. Clin Chem 1990;36:1440-3
12. Nacitarhan S, Ozben T, Tuncer N. Serum and urine malondialdehyde levels in NIDDM patients with and without hyperlipidemia. Free Radic Biol Med 1995;19:893-6
13. Stocs J, Dormandy TL. The autooxidation of human red cell lipids induced by hydrogen peroxide. Br J Haematol 1971;20:95-111
14. Tan S, Chan WM, Wai MS, Hui LK, Hui VW, James AE, et al. Ketamine effects on the urogenital system-Changes in the urinary bladder and sperm motility. Microsc Res Tech 2011;74:1192-8
15. Morgan CJ, Curran HV. Independent Scientific Committee on Drugs. Ketamine use: A review. Addiction 2012;107:27-38
16. Souza-Fiho MV, Lima MV, Pompeu MM, Ballejo G, Cunha FQ, Ribeiro RA. Involvement of nitric oxide in the pathogenesis of cyclophosphamide-induced hemorrhagic cystitis. Am J Pathol 1997;150:247-56
17. Korkmaz A, Topal T, Oter S. Pathophysiological aspects of cyclophosphamide and ifosfamide induced hemorrhagic cystitis; implication of reactive oxygen and nitrogen species as well as PARP activation. Cell Biol Toxicol 2007;23:303-12
18. Kawasaki T, Ogata M, Kawasaki C, Ogata J, Inoue Y, Shigematsu A. Ketamine suppresses proinflammatory cytokine production in human whole blood in vitro. Anesth Analg 1999;89:665-9
19. Topal T, Oztas Y, Korkmaz A, Sadir S, Oter S, Coskun O, et al. Melatonin ameliorates bladder damage induced by cyclophosphamide in rats. J Pineal Res 2005;38:272-7
20. Al-Yahya AA, Al-Majed AA, Gado AM, Daba MH, Al-Shabanah OA, Abd-Allah AR. Acacia Senegal gum exudate offers protection against cyclophosphamide-induced urinary bladder cytotoxicity. Oxid Med Cell Longev 2009;2:207-13
21. Ozcan A, Korkmaz A, Oter S, Coskun O. Contribution of flavonoid antioxidants to the preventive effect of mesna in cyclophosphamide-induced cystitis in rats. Arch Toxicol 2005;79:461-5
22. Shibakawa YS, Sasaki Y, Goshima Y, Echigo N, Kamiya Y, Kurahashi K, et al. Effects of ketamine and propofol on inflammatory responses of primary glial cell cultures stimulated with lipopolysaccharide. Br J Anaesth 2005;95:803-10
23. Salman AE, Dal D, Salman MA, Iskit AB, Aypar U. The effect of ketamine on acute muscular ischaemia reperfusion in rats. Eur J Anaesthesiol 2005;22:712-6