Evaluation of new morphometric parameters of neoangiogenesis in human colorectal cancer using confocal laser endomicroscopy (CLE) and targeted panendothelial markers

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Ciocâlteu, Adriana ^a   Sǎftoiu, Adrian ^a   Cârţânǎ, Tatiana ^a   Gruionu, Lucian Gheorghe ^a,b   Pirici, Daniel ^a   Georgescu, Corneliu Cristian ^a,c   Georgescu, Claudia Valentina ^c   Gheonea, Dan Ionuţ ^a   Gruionu, Gabriel ^a,d  

^a UNIVERSITY OF MEDICINE AND PHARMACY OF CRAIOVA   (Romania)

^b UNIVERSITY OF CRAIOVA   (Romania)

^c Emergency County Hospital   (Romania)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD31 ANTIGEN; TUMOR MARKER;

ANGIOGENESIS; ARTICLE; BLOOD VESSEL DIAMETER; CANCER STAGING; CAPILLARY DENSITY; CLINICAL ARTICLE; CLINICAL EVALUATION; COLORECTAL CARCINOMA; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; EX VIVO STUDY; FEASIBILITY STUDY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; INTERMETHOD COMPARISON; LASER MICROSCOPE; MICROVASCULARIZATION; MORPHOMETRICS; REPRODUCIBILITY; TUMOR BIOPSY; COLORECTAL TUMOR; CONFOCAL MICROSCOPY; ENDOTHELIUM; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PROCEDURES; VASCULARIZATION;

ANTIGENS, CD31; BIOMARKERS, TUMOR; COLORECTAL NEOPLASMS; ENDOTHELIUM; HUMANS; IMMUNOHISTOCHEMISTRY; MICROSCOPY, CONFOCAL; NEOVASCULARIZATION, PATHOLOGIC;

EID: 84897518326     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0091084     Document Type: Article

References (30)

1. Ellis LM, Walker RA, Gasparini G (1998) Is determination of angiogenic activity in human tumours clinically useful?. Eur J Cancer 34(5): 609-618.
2. Goel S, Duda DG, Xu L, Munn LL, Boucher Y, et al. (2011) Normalization of the vasculature for treatment of cancer and other diseases. Physiol Rev 91(3): 1071-1121.
3. Magnon C, Galaup A, Rouffiac V, Opolon P, Connault E, et al. (2007) Dynamic assessment of antiangiogenic therapy by monitoring both tumoral vascularization and tissue degeneration. Gene Therapy 14: 108-117. (Pubitemid 46043817)
4. Tong RT, Boucher Y, Kozin SV, Winkler F, Hicklin DJ, et al. (2004) Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Cancer Res 64: 3731-3736. (Pubitemid 38697278)
5. Lee CG, Heijn M, di Tomaso E, Griffon-Etienne G, Ancukiewicz M, et al. (2000) Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions. Cancer Res 60: 5565-5570.
6. Tatum JL, Hoffman JM (2000) Role of imaging in clinical trials of antiangiogenesis therapy in oncology. Acad Radiol 7(10): 798-9.
7. Gheonea DI, Cârţânǎ T, Ciurea T, Popescu C, Bǎdǎrǎu A, et al. (2011) Confocal laser endomicroscopy and immunoendoscopy for real-time assessment of vascularization in gastrointestinal malignancies. World J Gastroenterol 17(1): 21-27.
8. Ehling J, Lammers T, Kiessling F (2013) Non-invasive imaging for studying antiangiogenic therapy effects. Thromb Haemost 109(3): 375-90.
9. Cârţânǎ T, Sǎftoiu A, Gruionu LG, Gheonea DI, Pirici D, et al. (2012) Confocal laser endomicroscopy for the morphometric evaluation of microvessels in human colorectal cancer using targeted anti-CD31 antibodies. PloS ONE 7(12): e52815.
10. Gruionu G, Hoying JB, Pries AR, Secomb TW (2005) Structural remodeling of mouse gracilis artery after chronic alteration in blood supply. Am J Physiol Heart Circ Physiol 288: H2047-H2054. (Pubitemid 40604086)
11. Konerding MA, Fait E, Gaumann A (2001) 3D microvascular architecture of pre-cancerous lesions and invasive carcinomas of the colon. Br J Cancer 84: 1354-1362. (Pubitemid 32522104)
12. Mizuno K, Kudo SE, Ohtsuka K, Hamatani S, Wada Y, et al. (2011) Narrow-banding images and structures of microvessels of colonic lesions. Dig Dis Sci 56(6): 1811-1817.
13. Kachlik D, Baca V, Stingl J (2010) The spatial arrangement of the human large intestinal wall blood circulation. J Anat 216(3): 335-343.
14. Less JR, Posner MC, Skalak TC, Wolmark N, Jain RK (1997) Geometric resistance and microvascular network architecture of human colorectal carcinoma. Microcirculation 4(1): 25-33. (Pubitemid 127717664)
15. Fukumura D, Duda DG, Munn LL, Jain RK (2010) Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models. Microcirculation 17: 206-225.
16. Meining A, Wallace MB (2008) Endoscopic Imaging of Angiogenesis In Vivo. Gastroenterology 134(4): 915-918. (Pubitemid 351452008)
17. Yuan F, Chen Y, Dellian M, Safabakhsh N, Ferrara N, et al. (1996) Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody. Proc Natl Acad Sci 93: 14765-14770. (Pubitemid 26419043)
18. Jain RK (2001) Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. Nature Medicine 7: 987-989.
19. Bullitt E, Gerig G, Pizer SM, Lin W, Aylward SR (2003) Measuring Tortuosity of the Intracerebral Vasculature from MRA Images. IEEE Trans on Med Imaging 22(9): 1163-1171.
20. Jain RK (1988) Determinants of tumor blood flow: a review. Cancer Res 48(10): 2641-58.
21. Lang S, Müller B, Dominietto MD, Cattin PC, Zanette I, et al. (2012) Threedimensional quantification of capillary networks in healthy and cancerous tissues of two mice. Microvasc Res 84(3): 314-22.
22. Baish JS, Jain RK (2000) Fractals and cancer. Cancer Res 60: 3683-3688.
23. Bullitt E, Zeng D, Gerig G, Aylward S, Joshi S, et al. (2005) Vessel tortuosity and brain tumor malignancy: a blinded study. Acad Radiol 12(10): 1232-1240. (Pubitemid 41354249)
24. Sherman TF (1981) On connecting large vessels to small. The meaning of Murray's law.The Journal of General Physiology 78 (4): a 431-453.
25. Cheung ATW, Young LJT, Chen PCY, Chao CY, Ndoye A, et al. (1997) Microcirculation and metastasis in new mouse mammary tumor model system International Journal of Oncology 11: 69-77. (Pubitemid 27287098)
26. Savai R, Langheinrich AC, Schermuly RT, Pullamsetti SS, Dumitrascu R, et al. (2009) Evaluation of angiogenesis using micro-computed tomography in a xenograft mouse model of lung cancer. Neoplasia 11(1): 48-56.
27. Goel S, Hon-Kit Wong A, Jain RK (2012) Vascular normalization as a therapeutic strategy for malignant and non-malignant disease. Cold Spring Harb Perspect Med 2(3): a006486.
28. Li M, Zuo XL, Yu T, Gu XM, Zhou CJ, et al. (2013) Surface maturation scoring for oesophageal squamous intraepithelial neoplasia: a novel diagnostic approach inspired by first endomicroscopic 3-dimensional reconstruction. Gut 62(11): 1547-55.
29. Goetz M, Thomas S, Heimann A, Delaney P, Schneider C, et al. (2008) Dynamic in vivo imaging of microvasculature and perfusion by miniaturized confocal laser microscopy. Eur Surg Res 41: 290-297.
30. Cheong L, Lin F, Seah H, Qian K, Zhao F, et al. (2009) Embedded computing for fluorescence confocal endomicroscopy imaging. J. Signal Processing Systems 55: 217-228.