Application of the Dynamic Gastric Model to evaluate the effect of food on the drug release characteristics of a hydrophilic matrix formulation

International Journal of Pharmaceutics

Volumn 466, Issue 1-2, 2014, Pages 359-367

  Chessa, S ^a   Huatan, H ^a   Levina, M ^b   Mehta, R Y ^b   Ferrizzi, D ^b   Rajabi Siahboomi, A R ^b  

^a INSTITUTE OF FOOD RESEARCH   (United Kingdom)

^b Colorcon Inc Global Headquarters ^*  (United States)

Author keywords

Bio relevant; Dissolution; Dynamic Gastric Model; Food effect; HPMC; Hydrochlorothiazide; Hydrophilic matrix; Hydroxypropylmethyl cellulose

Indexed keywords

BILE SALT; HYDROCHLOROTHIAZIDE; HYDROXYPROPYLMETHYLCELLULOSE; PANCREAS ENZYME; TABLET;

ARTICLE; DRUG RELEASE; DRUG SOLUBILITY; FOOD; HUMAN; HYDROPHILICITY; IN VITRO STUDY; INTESTINE; MATRIX TABLET; PRIORITY JOURNAL; STOMACH EMPTYING; STOMACH SECRETION; TABLET FORMULATION; VISCOSITY; BIOLOGICAL MODEL; CHEMICAL PHENOMENA; CHEMISTRY; DIGESTION; DUODENUM; FOOD DRUG INTERACTION; MEDICINAL CHEMISTRY; METABOLISM; SOLUBILITY; STOMACH; TABLET;

CHEMISTRY, PHARMACEUTICAL; DIGESTION; DUODENUM; FOOD-DRUG INTERACTIONS; HUMANS; HYDROCHLOROTHIAZIDE; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MODELS, BIOLOGICAL; SOLUBILITY; STOMACH; TABLETS;

EID: 84897513965     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.03.031     Document Type: Article

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