Design, synthesis, acetylcholinesterase inhibition and larvicidal activity of girgensohnine analogs on Aedes aegypti, vector of dengue fever

European Journal of Medicinal Chemistry

Volumn 78, Issue , 2014, Pages 392-400

  Carreño Otero, Aurora L ^a   Vargas Méndez, Leonor Y ^b   Duque L , Jonny E ^a   Kouznetsov, Vladimir V ^a  

^a UNIVERSIDAD INDUSTRIAL DE SANTANDER   (Colombia)

^b UNIVERSIDAD SANTO TOMÁS   (Colombia)

Author keywords

AChE inhibition; Aedes aegypti larvae; Larvicidal activity; Strecker reaction; Aminonitriles

Indexed keywords

2 (3 HYDROXY 4 METHOXYPHENYL) 2 (4 METHYLPIPERAZIN 1 YL)ACETONITRILE; 2 (3 HYDROXY 4 METHOXYPHENYL) 2 (MORPHOLIN 1 YL)ACETONITRILE; 2 (3 HYDROXY 4 METHOXYPHENYL) 2 (PIPERIDIN 1 YL)ACETONITRILE; 2 (3 HYDROXY 4 METHOXYPHENYL) 2 (PYRROLIDIN 1 YL)ACETONITRILE; 2 (3,4 DIMETHOXYPHENYL) 2 (4 METHYLPIPERAZIN 1 YL)ACETONITRILE; 2 (3,4 DIMETHOXYPHENYL) 2 (MORPHOLIN 1 YL)ACETONITRILE; 2 (3,4 DIMETHOXYPHENYL) 2 (PIPERIDIN 1 YL)ACETONITRILE; 2 (3,4 DIMETHOXYPHENYL) 2 (PYRROLIDIN 1 YL)ACETONITRILE; 2 (3,4 DIOXYMETHYLENPHENYL) 2 (4 METHYLPIPERAZIN 1 YL)ACETONITRILE; 2 (3,4 DIOXYMETHYLENPHENYL) 2 (MORPHOLIN 1 YL)ACETONITRILE; 2 (3,4 DIOXYMETHYLENPHENYL) 2 (PIPERIDIN 1 YL)ACETONITRILE; 2 (3,4 DIOXYMETHYLENPHENYL) 2 (PYRROLIDIN 1 YL)ACETONITRILE; 2 (3,4,5 TRIMETHOXYPHENYL) 2 (4 METHYLPIPERAZIN 1 YL)ACETONITRILE; 2 (3,4,5 TRIMETHOXYPHENYL) 2 (MORPHOLIN 1 YL)ACETONITRILE; 2 (3,4,5 TRIMETHOXYPHENYL) 2 (PIPERIDIN 1 YL)ACETONITRILE; 2 (3,4,5 TRIMETHOXYPHENYL) 2 (PYRROLIDIN 1 YL)ACETONITRILE; 2 (4 HYDROXY 3 METHOXYPHENYL) 2 (4 METHYLPIPERAZIN 1 YL)ACETONITRILE; 2 (4 HYDROXY 3 METHOXYPHENYL) 2 (PIPERIDIN 1 YL)ACETONITRILE; 2 (4 HYDROXY 3 METHOXYPHENYL) 2 (PYRROLIDIN 1 YL)ACETONITRILE; 2 (4 HYDROXY 3 METHOXYPHENYL) 2 MORPHOLINOACETONITRILE; 2 (4 HYDROXYPHENYL) 2 (PIPERIDIN 1 YL)ACETONITRILE; ACETYLCHOLINESTERASE; ALKALOID DERIVATIVE; CHOLINESTERASE INHIBITOR; GIRGENSOHNINE; LARVICIDAL AGENT; UNCLASSIFIED DRUG; INSECTICIDE; NITRILE; PYRROLIDINE DERIVATIVE;

AEDES AEGYPTI; ARTHROPOD LARVA; ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; IN VITRO STUDY; IN VIVO STUDY; INSECTICIDAL ACTIVITY; LIPOPHILICITY; NONHUMAN; AEDES; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DENGUE; DISEASE CARRIER; DOSE RESPONSE; DRUG EFFECTS; LARVA; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ACETYLCHOLINESTERASE; AEDES; ANIMALS; CHOLINESTERASE INHIBITORS; DENGUE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; INSECT VECTORS; INSECTICIDES; LARVA; MOLECULAR STRUCTURE; NITRILES; PYRROLIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84897509717     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.03.067     Document Type: Article

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