Thyroid hormone inactivation in gastrointestinal stromal tumors

New England Journal of Medicine

Volumn 370, Issue 14, 2014, Pages 1327-1334

  Maynard, Michelle A ^a   Marino Enriquez, Adrian ^b   Fletcher, Jonathan A ^b,c   Dorfman, David M ^b   Raut, Chandrajit P ^b,c   Yassa, Leila ^b   Guo, Cuicui ^a   Wang, Yuexiang ^b   Dorfman, Clara ^a   Feldman, Henry A ^a   Frates, Mary C ^b   Song, Huaidong ^a   Jugo, Rebecca H ^a   Taguchi, Takahiro ^d   Hershman, Jerome M ^e   Larsen, P Reed ^b,c   Huang, Stephen A ^a,b,c  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d KOCHI MEDICAL SCHOOL   (Japan)

^e VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMATINIB; IODIDE PEROXIDASE; IOPANOIC ACID; LEVOTHYROXINE; LIOTHYRONINE; MESSENGER RNA; SORAFENIB; SUNITINIB; THYROID HORMONE; THYROTROPIN; THYROXINE; TYPE 3 IODOTHYRONINE DEIODINASE; UNCLASSIFIED DRUG;

ADULT; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER MORTALITY; CARCINOGENESIS; CASE REPORT; CELL PROLIFERATION; CELL VIABILITY; COLON RESECTION; COMPUTER ASSISTED TOMOGRAPHY; CONSUMPTIVE HYPOTHYROIDISM; CONTROLLED STUDY; DEIODINATION; DRUG MEGADOSE; DRUG SUBSTITUTION; DRUG TREATMENT FAILURE; DRUG WITHDRAWAL; ENZYME ACTIVITY; ENZYME INHIBITION; EXON; GASTRECTOMY; GASTROINTESTINAL BIOPSY; GASTROINTESTINAL STROMAL TUMOR; GENE; GENE MUTATION; GENOTYPE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOPATHOLOGY; HORMONE TRANSPORT; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOTHYROIDISM; MALE; ONCOGENE C KIT; PATIENT COMPLIANCE; PATIENT MONITORING; PDGFRA GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL; TUMOR BIOPSY; TUMOR VOLUME; VISCERAL METASTASIS;

GASTROINTESTINAL NEOPLASMS; GASTROINTESTINAL STROMAL TUMORS; HUMANS; HYPOTHYROIDISM; IODIDE PEROXIDASE; MALE; MIDDLE AGED; RADIOGRAPHY, ABDOMINAL; THYROID HORMONES;

EID: 84897494194     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa1308893     Document Type: Article

References (25)

1. Liegl-Atzwanger B, Fletcher JA, Fletcher CD. Gastrointestinal stromal tumors. Virchows Arch 2010;456:111-27.
2. Hamnvik OP, Larsen PR, Marqusee E. Thyroid dysfunction from antineoplastic agents. J Natl Cancer Inst 2011;103:1572-87.
3. Wong E, Rosen LS, Mulay M, et al. Sunitinib induces hypothyroidism in advanced cancer patients and may inhibit thyroid peroxidase activity. Thyroid 2007;17:351-5.
4. Kappers MH, van Esch JH, Smedts FM, et al. Sunitinib-induced hypothyroidism is due to induction of type 3 deiodinase activity and thyroidal capillary regression. J Clin Endocrinol Metab 2011;96:3087-94.
5. Huang SA, Mulcahey MA, Crescenzi A, et al. Transforming growth factor-beta promotes inactivation of extracellular thyroid hormones via transcriptional stimulation of type 3 iodothyronine deiodinase. Mol Endocrinol 2005;19:3126-36. (Pubitemid 41697726)
6. Huang SA, Dorfman DM, Genest DR, Salvatore D, Larsen PR. Type 3 iodothyronine deiodinase is highly expressed in the human uteroplacental unit and in fetal epithelium. J Clin Endocrinol Metab 2003;88:1384-8. (Pubitemid 36337804)
7. Taguchi T, Sonobe H, Toyonaga S, et al. Conventional and molecular cytogenetic characterization of a new human cell line, GIST-T1, established from gastrointestinal stromal tumor. Lab Invest 2002;82:663-5. (Pubitemid 34522379)
8. Dang ZC, Lowik CW. Removal of serum factors by charcoal treatment promotes adipogenesis via a MAPK-dependent pathway. Mol Cell Biochem 2005;268:159-67. (Pubitemid 40287838)
9. Refetoff S, Robin NI, Fang VS. Parameters of thyroid function in serum of 16 selected vertebrate species: a study of PBI, serum T4, free T4, and the pattern of T4 and T3 binding to serum proteins. Endocrinology 1970;86:793-805.
10. Huang SA, Tu HM, Harney JW, et al. Severe hypothyroidism caused by type 3 iodothyronine deiodinase in infantile hemangiomas. N Engl J Med 2000;343:185-9. (Pubitemid 30489216)
11. Dentice M, Luongo C, Huang S, et al. Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes. Proc Natl Acad Sci U S A 2007;104:14466-71. (Pubitemid 350003284)
12. Balazs AE, Athanassaki I, Gunn SK, et al. Rapid resolution of consumptive hypothyroidism in a child with hepatic hemangioendothelioma following liver transplantation. Ann Clin Lab Sci 2007;37:280-4. (Pubitemid 47311348)
13. Huang SA. Physiology and pathophysiology of type 3 deiodinase in humans. Thyroid 2005;15:875-81. (Pubitemid 41339266)
14. Howard D, La Rosa FG, Huang S, et al. Consumptive hypothyroidism resulting from hepatic vascular tumors in an athyreotic adult. J Clin Endocrinol Metab 2011;96:1966-70.
15. Huang SA, Fish SA, Dorfman DM, et al. A 21-year-old woman with consumptive hypothyroidism due to a vascular tumor expressing type 3 iodothyronine deiodinase. J Clin Endocrinol Metab 2002;87:4457-61. (Pubitemid 35247024)
16. Ruppe MD, Huang SA, Jan de Beur SM. Consumptive hypothyroidism caused by paraneoplastic production of type 3 iodothyronine deiodinase. Thyroid 2005;15:1369-72.
17. Hirota S, Isozaki K, Moriyama Y, et al. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science 1998;279:577-80. (Pubitemid 28067289)
18. Heinrich MC, Corless CL, Duensing A, et al. PDGFRA activating mutations in gastrointestinal stromal tumors. Science 2003;299:708-10. (Pubitemid 36159485)
19. da Rocha ST, Edwards CA, Ito M, Ogata T, Ferguson-Smith AC. Genomic imprinting at the mammalian Dlk1-Dio3 domain. Trends Genet 2008;24:306-16.
20. Subramanian S, West RB, Corless CL, et al. Gastrointestinal stromal tumors (GISTs) with KIT and PDGFRA mutations have distinct gene expression profiles. Oncogene 2004;23:7780-90. (Pubitemid 39457028)
21. Desai J, Yassa L, Marqusee E, et al. Hypothyroidism after sunitinib treatment for patients with gastrointestinal stromal tumors. Ann Intern Med 2006;145:660-4. (Pubitemid 46768841)
22. Mannavola D, Coco P, Vannucchi G, et al. A novel tyrosine-kinase selective inhibitor, sunitinib, induces transient hypothyroidism by blocking iodine uptake. J Clin Endocrinol Metab 2007;92:3531-4. (Pubitemid 47435331)
23. Abdulrahman RM, Verloop H, Hoftijzer H, et al. Sorafenib-induced hypothyroidism is associated with increased type 3 deiodination. J Clin Endocrinol Metab 2010;95:3758-62.
24. Hollowell JG, Staehling NW, Flanders WD, et al. Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab 2002;87:489-99. (Pubitemid 34158210)
25. Huang SA, Bianco AC. Reawakened interest in type III iodothyronine deiodinase in critical illness and injury. Nat Clin Pract Endocrinol Metab 2008;4:148-55. (Pubitemid 351301780)