Comparison of erythropoietin and sildenafil protective role against ischemia/reperfusion injury of the testis in adult rats

International Urology and Nephrology

Volumn 46, Issue 4, 2014, Pages 731-736

  Zavras, Nick ^a   Kostakis, Ioannis D ^b,c,e   Sakellariou, Stratigoula ^b   Damaskos, Christos ^b,c   Roupakas, Evangelos ^b,c   Tsagkari, Eleni ^b,c   Spartalis, Eleftherios ^b,c   Velaoras, Konstantinos ^d   Dontas, Ismene A ^b   Karatzas, Theodore ^b,c  

^a NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS   (Greece)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^c UNIVERSITY OF ATHENS   (Greece)

^d PENTELI CHILDREN S HOSPITAL   (Greece)

^e Department of Pediatric Surgery Penteli General Children's Hospital ^*  (Greece)

Author keywords

Erythropoietin; Ischemia reperfusion injury; Rats; Sildenafil; Testicular torsion

Indexed keywords

NOVEL ERYTHROPOIESIS STIMULATING PROTEIN; SILDENAFIL; ERYTHROPOIETIN; PHOSPHODIESTERASE V INHIBITOR; PIPERAZINE DERIVATIVE; PURINE DERIVATIVE; SULFONE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HISTOPATHOLOGY; MALE; NONHUMAN; RAT; REPERFUSION INJURY; TESTIS DETORSION; TESTIS DISEASE; TESTIS INJURY; TESTIS TORSION; TREATMENT OUTCOME; ANIMAL; COMPARATIVE STUDY; COMPLICATION; INTRAPERITONEAL DRUG ADMINISTRATION; PATHOLOGY; TESTIS; VASCULARIZATION; WISTAR RAT;

ANIMALS; ERYTHROPOIETIN; INJECTIONS, INTRAPERITONEAL; MALE; PHOSPHODIESTERASE 5 INHIBITORS; PIPERAZINES; PURINES; RATS, WISTAR; REPERFUSION INJURY; SPERMATIC CORD TORSION; SULFONES; TESTIS;

EID: 84897491904     PISSN: 03011623     EISSN: 15732584     Source Type: Journal    
DOI: 10.1007/s11255-013-0569-x     Document Type: Article

References (24)

1. Kapoor S (2008) Testicular torsion: a race against time. Int J Clin Pract 62:821-827. doi: 10.1111/j.1742-1241.2008.01727.x
2. Gatti JM, Patrick Murphy J (2007) Current management of the acute scrotum. Semin Pediatr Surg 16:58-63
3. Ringdahl E, Teague L (2006) Testicular torsion. Am Fam Physician 74:1739-1743
4. Turner TT, Bang HJ, Lysiak JL (2004) The molecular pathology of experimental testicular torsion suggests adjunct therapy to surgical repair. J Urol 172:2574-2578
5. Altavilla D, Romeo C, Squadrito F, Marini H, Morgia G, Antonuccio P, Minutoli L (2012) Molecular pathways involved in the early and late damage induced by testis ischemia: evidence for a rational pharmacological modulation. Curr Med Chem 19:1219-1224
6. Mellick LB (2012) Torsion of the testicle: it is time to stop tossing the dice. Pediatr Emerg Care 28:80-86. doi: 10.1097/PEC.0b013e31823f5ed9
7. Reyes JG, Farias JG, Henríquez-Olavarrieta S, Madrid E, Parraga M, Zepeda AB, Moreno RD (2012) The hypoxic testicle: physiology and pathophysiology. Oxid Med Cell Longev 2012:929285. doi: 10.1155/2012/929285. Epub2012Sep27
8. Filho DW, Torres MA, Bordin AL, Crezcynski-Pasa TB, Boveris A (2004) Spermatic torsion, reactive oxygen and nitrogen species and ischemia-reperfusion injury. Mol Aspects Med 25:199-210
9. Lysiak JJ (2004) The role of tumor necrosis factor-Alpha and interleukin-1 in the mammalian testis and their involvement in testicular torsion and autoimmune orchitis. Reprod Biol Endocrinol 2:9
10. Paschos N, Lykissas MG, Beris AE (2008) The role of erythropoietin as an inhibitor of tissue ischemia. Int J Biol Sci 4:161-168
11. Kukreja RC, Salloum F, Das A, Ockaili R, Yin C, Bremer YA, Fisher PW, Wittkamp M, Hawkins J, Chou E, Kukreja AK, Wang X, Marwaha VR, Xi L (2005) Pharmacological preconditioning with sildenafil: basic mechanisms and clinical implications. Vascul Pharmacol 42:219-232
12. Köseoǧlu B, Yilmaz E, Ceylan K, Uzun E, Bayram I, Hizli F (2009) The protective effect of erythropoietin infusion on testicular torsion/detorsion: an experimental study. Int Urol Nephrol 41:85-91. doi: 10.1007/s11255-008-9418-8
13. Beheshtian A, Salmasi AH, Payabvash S, Kiumehr S, Ghazinezami B, Rahimpour S, Tavangar SM, Dehpour AR (2008) Protective effects of sildenafil administration on testicular torsion/detorsion damage in rats. World J Urol 26:197-202. doi: 10.1007/s00345-008-0243-6
14. YIldIz H, Durmus AS, Şimşek H, Yaman M (2012) Dose-dependent protective effect of sildenafil citrate on testicular injury after torsion/detorsion in rats. Andrologia 44:300-306. doi: 10.1111/j.1439-0272.2011.01181.x
15. Yildiz H, Durmuş AS, Şimşek H, Yaman İ (2011) Effects of sildenafil citrate on torsion/detorsion-induced changes in red blood cell and plasma lipid peroxidation, antioxidants, and blood hematology of male rats. Eur J Obstet Gynecol Reprod Biol 159:359-363. doi: 10.1016/j.ejogrb.2011. 07.023
16. Yíldíz H, Durmus AS, Simşek H, Yaman M (2011) Protective effect of sildenafil citrate on contralateral testis injury after unilateral testicular torsion/detorsion. Clinics (Sao Paulo) 66:137-142
17. Cosentino MJ, Nishida M, Rabinowitz R, Cockett AT (1985) Histological changes occurring in the contralateral testes of prepubertal rats subjected to various durations of unilateral spermatic cord torsion. J Urol 133:906-911
18. Yazihan N, Ataoglu H, Koku N, Erdemli E, Sargin AK (2007) Protective role of erythropoietin during testicular torsion of the rats. World J Urol 25:531-536
19. Akcora B, Altug ME, Kontas T, Atik E (2007) The protective effect of darbepoetin alfa on experimental testicular torsion and detorsion injury. Int J Urol 14:846-850
20. Ergur BU, Kiray M, Pekcetin C, Bagriyanik HA, Erbil G (2008) Protective effect of erythropoietin pretreatment in testicular ischemia-reperfusion injury in rats. J Pediatr Surg 43:722-728. doi: 10.1016/j.jpedsurg.2007.11.028
21. Rashed FK, Ghasemi B, Deldade Mogaddam H, Mesgari M (2013) The effect of erythropoietin on ischemia/reperfusion injury after testicular torsion/detorsion: a randomized experimental study. ISRN Urol 2013:351309. doi: 10.1155/2013/351309
22. Halawa AM (2010) Effect of sildenafil administration on ischemia/reperfusion of the testis in adult Albino rat light and electron microscopic study. Egypt J Histol 33:380-395
23. Istanbulluoglu MO, Zor M, Celik A, Cicek T, Basal S, Ozgok A, Ustun H, Ozgok Y (2011) Effects of vardenafil on testicular torsion/detorsion damage: an experimental study in pigs. Urol Int 86:228-232. doi: 10.1159/000321492
24. Erol B, Tokgoz H, Hanci V, Bektas S, Akduman B, Yencilek F, Mungan G, Mungan A (2009) Vardenafil reduces testicular damage following ischemia/reperfusion injury in rats. Kaohsiung J Med Sci 25:374-380. doi: 10.1016/S1607-551X(09)70530-3