Effects of sildenafil citrate on torsion/detorsion-induced changes in red blood cell and plasma lipid peroxidation, antioxidants, and blood hematology of male rats

European Journal of Obstetrics and Gynecology and Reproductive Biology

Volumn 159, Issue 2, 2011, Pages 359-363

  Yildiz, Hamit ^a   Durmu, Ali Said ^a   Imek, Halil ^b   Yaman, Hsan ^a  

^a FIRAT UNIVERSITY   (Turkey)

^b University of Bingol   (Turkey)

Author keywords

Biochemical; Hematology; Sildenafil citrate; Testicular torsion

Indexed keywords

ALPHA CAROTENE; ALPHA TOCOPHEROL; ANTIOXIDANT; ARYLDIALKYLPHOSPHATASE 1; BETA CAROTENE; CATALASE; GLUTATHIONE; HEMOGLOBIN; MALONALDEHYDE; NITRIC OXIDE; SILDENAFIL; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BASOPHIL; BLOOD CELL COUNT; CONTROLLED STUDY; DRUG MEGADOSE; EOSINOPHIL COUNT; ERYTHROCYTE; HEMATOCRIT; HEMATOLOGY; HEMOGLOBIN BLOOD LEVEL; LIPID PEROXIDATION; LOW DRUG DOSE; LYMPHOCYTE COUNT; MALE; MEAN CORPUSCULAR HEMOGLOBIN; MEAN CORPUSCULAR VOLUME; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; TESTIS; TESTIS TORSION;

EID: 82255191773     PISSN: 03012115     EISSN: 18727654     Source Type: Journal    
DOI: 10.1016/j.ejogrb.2011.07.023     Document Type: Article

References (34)

1. H.M. Prillman, and T.T. Turner Rescue of testicular function after acute experimental torsion J Urol 157 1997 340 345
2. M.S. Paller, J.R. Hoidal, and T.F. Ferris Oxygen free radical in ischemic acute renal failure in the rat J Clin Invest 74 1984 1156 1164
3. A. Beheshtian, A.H. Salmasi, and S. Payabvash Protective effects of sildenafil administration on testicular torsion/detorsion damage in rats World J Urol 26 2008 197 202
4. B. Erol, H. Tokgoz, and V. Hanci Vardenafil reduces testicular damage following ischemia/reperfusion injury in rats Kaohsiung J Med Sci 25 2009 374 380
5. Y. Serarslan, Z. Yonden, and E. Ozgiray Protective effects of tadalafil on experimental spinal cord injury in rats J Clin Neurosci 17 2010 349 352
6. phos NAD(P)H oxidase induced by the thromboxane A2 mimetic, U46619, in corpus cavernosal smooth muscle cells Br J Urol Int 96 2005 423 427
7. T.J. Toward, N. Smith, and K.J. Broadley Effect of phosphodiesterase-5 inhibitor, sildenafil (Viagra), in animal models of airways disease Am J Respir Crit Care Med 169 2004 227 234
8. H. Uzun, D. Konukoglu, M.K. Nuri, E.Y. Ersoy, S. Ozevik, and N. Yavuz The effects of sildenafil citrate on ischemic colonic anastomotic healing in rats: its relationship between nitric oxide and oxidative stress World J Surg 32 2008 2107 2113
9. Y. Kohda, and M. Gemba Modulation by cyclic AMP and phorbol myristate acetate of cephaloridine-induced injury in rat renal cortical slices Jpn J Pharmacol 85 2001 54 59
10. D.C. Arikan, V. Bakan, E.B. Kurutas, H. Sayar, and A. Coskun Protective effect of tadalafil on ischemia/reperfusion injury of rat ovary J Pediatr Surg 45 2010 2203 2209
11. S. Korom, S. Hillinger, and M. Cardell Sildenafil extends survival and graft function in a large animal lung transplantation model Eur J Cardiothorac Surg 29 2006 288 293
12. Z.A. Placer, L. Cushman, and B.C. Johnson Estimation of products of lipid peroxidation (malonyl dialdehyde) in biological fluids Anal Biochem 16 1966 359 364
13. L.A. Goth A simple method for determination of serum catalase activity and revision of reference range Clin Chim Acta 196 1991 143 152
14. J. Sedlak, and R.H.C. Lindsay Estimation of total, protein bound and non-protein sulfhydryl groups in tissue with Ellmann's reagent Anal Biochem 25 1968 192 205
15. R.A. Lawrence, and R.F. Burk Glutathione peroxidase activity in selenium-deficient rat liver Biochem Biophys Res Commun 71 1976 952 958
16. Y. Sun, L.W. Oberley, and Y. Li A simple method for clinical assay of superoxide dismutase Clin Chem 34 1988 497 500
17. O.H. Lowry, N.J. Rosebrough, A.L. Farr, and R.J. Randall Protein measurement with the Folin-Phenol reagent J Biol Chem 193 1951 265 275
18. I.D. Desia Vitamin E analysis methods for animal tissues Methods Enzymol 105 1984 138 147
19. J. Suzuki, and N.A. Katoh Simple and cheap methods for measuring serum vitamin A in cattle using only a spectrophotometer Jpn J Vet Sci 52 1990 1282 1284
20. C.E. Furlong, R.J. Richter, S.L. Seidel, L.G. Costa, and A.G. Matulsky Spectrophotometric assays for the enzymatic hydrolysis of the active metabolites of chlorpyrifos and parathion by plasma paraoxonase/arylesterase Anal Biochem 180 1989 242 247
21. N.K. Cortas, and N.W. Wakid Determination of inorganic nitrate in serum and urine by a kinetic cadmium-reduction method Clin Chim 36 1990 1440 1443
22. O.W. Schalm, N.C. Jain, and E.J. Carroll Veterinary hematology 3rd ed. 1975 Lea & Febiger Philadelphia, PA
23. H. Perk, A. Armagan, and M. Naziroglu Sildenafil citrate as a phosphodiesterase inhibitor has an antioxidant effect in the blood of men J Clin Pharm Ther 33 2008 635 640
24. B. Rodriguez-Iturbe, A. Ferrebuz, and V. Vanegas Early treatment with cGMP phosphodiesterase inhibitor ameliorates progression of renal damage Kidney Int 68 2005 2131 2142
25. E.F. du Toit, E. Rossouw, R. Salie, L.H. Opie, and A. Lochner Effect of sildenafil on reperfusion function, infarct size, and cyclic nucleotide levels in the isolated rat heart model Cardiovasc Drugs Ther 19 2005 23 31
26. T.M. Kolettis, K. Kontaras, and I. Spartinos Dose-dependent effects of sildenafil on post-ischaemic left ventricular function in the rat isolated heart J Pharm Pharmacol 62 2010 346 351
27. T. Reffelmann, and R.A. Kloner Effects of sildenafil on myocardial infarct size, microvascular function, and acute ischemic left ventricular dilation Cardiovasc Res 59 2003 441 449
28. J.W. Elrod, J.J. Greer, and D.J. Lefer Sildenafil-mediated acute cardioprotection is independent of the NO/cGMP pathway Am J Physiol Heart Circ Physiol 292 1 2007 342 347
29. A. Ayub, M.I. Mackness, S. Arrol, B. Mackness, J. Patel, and P.N. Durrington Serum paraoxonase after myocardial infarction Arterioscler Thromb Vasc Biol 19 1999 330 335
30. A. Verit, M. Savas, H. Ciftci, N. Aksoy, A. Taskin, and U. Topal Assessment of the acute effects of tadalafil on the cardiovascular system based on examination of serum oxidative status and paraoxonase activity in men with erectile dysfunction: a preliminary study Int J Impot Res 22 2010 115 119
31. O. Rozenberg, M. Shiner, M. Aviram, and T. Hayek Paraoxonase 1 (PON1) attenuates diabetes development in mice through its antioxidative properties Free Radical Biol Med 44 2008 1951 1959
32. L. De Young, D. Yu, R.M. Bateman, and G.B. Brock Oxidative stres and antioxidant therapy: their impact in diabetes-associated erectile dysfunction J Androl 25 2004 830 836
33. R. Daghfous, S. El Aidli, A. Zaiem, M.H. Loueslati, and C. Belkahia Sildenafil-associated hepatotoxicity Am J Gastroenterol 100 2005 1895 1896
34. J.A. Little, K.P. Hauser, and S.E. Martyr Hematologic, biochemical, and cardiopulmonary effects of l-arginine supplementation or phosphodiesterase 5 inhibition in patients with sickle cell disease who are on hydroxyurea therapy Eur J Haematol 82 2008 315 321