The effects of N-ethyl-N′-methyl imidazolium chloride on the solubility, stability and aggregation of tc-rPA

FEBS Journal

Volumn 281, Issue 7, 2014, Pages 1738-1749

  Tischer, Alexander ^a   Pultke, Heiko ^b   Topf, Andrea ^c   Auton, Matthew ^a   Lange, Christian ^b   Lilie, Hauke ^d  

^a MAYO GRADUATE SCHOOL   (United States)

^b Scil Proteins GmbH   (Germany)

^c HANNOVER MEDICAL SCHOOL   (Germany)

^d MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

aggregation; CM rPA; EMIMCl; protein solubility; tc rPA

Indexed keywords

AMINO ACID; GUANIDINE; IMIDAZOLE DERIVATIVE; N ETHYL N' METHYL IMIDAZOLIUM CHLORIDE; PLASMIN; RECOMBINANT PLASMINOGEN ACTIVATOR; UNCLASSIFIED DRUG; UREA;

ARTICLE; CIRCULAR DICHROISM; CONCENTRATION (PARAMETERS); DENATURATION; DENSITOMETRY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME STABILITY; LIGHT SCATTERING; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CLEAVAGE; PROTEIN DETERMINATION; PROTEIN INTERACTION; PROTEIN REFOLDING; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SOLUBILITY; ULTRAVIOLET SPECTROSCOPY; WATER CONTENT;

AGGREGATION; CM-RPA; EMIMCL; PROTEIN SOLUBILITY; TC-RPA;

CHLORIDES; IMIDAZOLES; PLASMINOGEN ACTIVATORS; PROTEIN DENATURATION; PROTEIN FOLDING; SOLUBILITY; SOLVENTS;

EID: 84897490190     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12736     Document Type: Article

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