Complexation of the tissue plasminogen activator protease with benzamidine-type inhibitors: Interference by the kringle 2 module

Biochemistry

Volumn 35, Issue 10, 1996, Pages 3270-3276

  Hu, Chih Kao ^a   Kohnert, Ulrich ^b   Stürzebecher, Jörg ^c   Fischer, Stephan ^b   Llinás, Miguel ^a  

^a CARNEGIE MELLON UNIVERSITY   (United States)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BENZAMIDINE DERIVATIVE; ENZYME INHIBITOR; PROTEINASE; RECOMBINANT PROTEIN; TISSUE PLASMINOGEN ACTIVATOR;

ARTICLE; COMPLEX FORMATION; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME INHIBITOR COMPLEX; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ANALYSIS;

AMINO ACID CHLOROMETHYL KETONES; BENZAMIDINES; DANSYL COMPOUNDS; HUMANS; KRINGLES; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PROTEASE INHIBITORS; SEQUENCE DELETION; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE PLASMINOGEN ACTIVATOR;

ESCHERICHIA COLI;

EID: 0029989436     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9515026     Document Type: Article

References (21)

1. Andreasen, P. A., Nielsen, L. S., Grøndahl-Hansen, J., Skriver, L., Zeuthen, J., Stephens, R. W., & Danø, K. (1984) EMBO J. 3, 51-56.
2. Andreasen, P. A., Petersen, L. C., & Danø, K. (1991) Fibrinolysis 5, 207-215.
3. Byeon, I.-J. L., Kelley, R. F., Mulkerrin, M., An, S. S., & Llinás, M. (1995) Biochemistry 34, 2739-2750.
4. De Marco, A. (1977) J. Magn. Reson. 26, 527-528.
5. De Marco, A., Petros, A. M., Laursen, R. A., & Llinás, M. (1987) Eur. Biophys. J. 14, 359-368.
6. Higgins, D., & Lamb, M. C. (1986) Arch. Biochem. Biophys. 249, 418-426.
7. Hu, C.-K., Kohnert, U., Wilhelm, O., Fischer, S., & Llinás, M. (1994) Biochemistry 33, 11760-11766.
8. Ichinose, A., Kisiel, W., & Fujikawa, K. (1984) FEBS Lett. 175, 412-418.
9. Kettner, C., & Shaw, E. (1979) Biochim. Biophvs. Acta 569, 31-40.
10. Kohnert, U., Rudolph, R., Verheijen, J. H., Weening-Verhoeff, E. J. D., Stern, A., Opitz, U., Martin, U., Lill, H., Prinz, H., Lechner, M., Kresse, G.-B., Buckel, P., & Fischer, S. (1992) Protein Eng. 5, 93-100.
11. Kohnert, U., Horsch, B., & Fischer, S. (1993) Fibrinolysis 7, 365-372.
12. Lehninger, A. L. (1975) Biochemistry, p 197, Worth Publishers, New York.
13. Loscalzo, J. (1988) J. Clin. Invest. 82, 1391-1397.
14. Nienaber, V. L., Young, S. L., Birktoft, J J., Higgins, D. L., & Berliner, L. J. (1992) Biochemistry 31, 3852-3861.
15. Strassburger, W., Wollmer, A., Pitts, J. E., Glover, I. D., Tickle, I. J., Blundell, T. L., Steffens, G. J., Günzler, W. A., Ötting, F., & Flohé, L. (1983) FEBS Lett. 157, 219-223.
16. Stürzebecher, J , Markwardt, F., Wagner. G., & Walsmann, P. (1976) Acta Biol. Med. Ger. 35, 1665-1676.
17. Sturzebecher, J., Neumann, U., Kohnert, U., Kresse, G.-B., & Fischer, S. (1992) Protein Sci. 1, 1007-1013.
18. Wagner, G. (1982) Folia Haematol. 109, 67-74.
19. Wallén, P., Ränby, M., Bergsdorf, N., & Kok, P. (1981) Prog. Fibrinolysis 5, 16-23.
20. Wallén, P., Bergsdorf, N., & Rånby, M (1982) Biochim. Biophys. Acta 719, 318-328.
21. Wallén, P., Pohl, G., Bergsdorf, N., Rånby, M, Ny, T., & Jörnvall, H. (1983) Eur. J. Biochem. 132, 681-686.