Synthesis and methemoglobinemia-inducing properties of benzocaine isosteres designed as humane rodenticides

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 7, 2014, Pages 2220-2235

  Conole, Daniel ^a   Beck, Thorsten M ^a   Jay Smith, Morgan ^a   Tingle, Malcolm D ^a   Eason, Charles T ^b,c   Brimble, Margaret A ^a   Rennison, David ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b LINCOLN UNIVERSITY   (New Zealand)

^c CAWTHRON INSTITUTE   (New Zealand)

Author keywords

Benzocaine; Isostere; Methemoglobin; Methemoglobinemia; Rat toxicant; Rodenticide

Indexed keywords

1,2,4 OXADIAZOLE DERIVATIVE; 1,3,4 OXADIAZOLE DERIVATIVE; BENZOCAINE; BENZOCAINE ISOSTERE; CARBON NITROGEN MONOCYCLE; DIAZINE DERIVATIVE; METHEMOGLOBIN; RODENTICIDE; TETRAZOLE DERIVATIVE; THIADIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; OXADIAZOLE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOLOGICAL ACTIVITY; BIOLOGICAL PEST CONTROL; CHEMICAL ANALYSIS; CHEMICAL COMPOSITION; CHEMICAL STRUCTURE; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; IN VITRO STUDY; IN VIVO STUDY; LETHALITY; LIPOPHILICITY; MALE; METHEMOGLOBINEMIA; NONHUMAN; PHYSICAL CHEMISTRY; RAT; SYNTHESIS; TOXICITY TESTING; ANIMAL; BIOSYNTHESIS; CHEMISTRY; DRUG DESIGN; METABOLISM; SPRAGUE DAWLEY RAT; WISTAR RAT;

RATTUS;

ANIMALS; BENZOCAINE; DRUG DESIGN; FEMALE; MALE; METHEMOGLOBIN; METHEMOGLOBINEMIA; MOLECULAR STRUCTURE; OXADIAZOLES; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RODENTICIDES;

EID: 84897454745     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.02.013     Document Type: Article

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