Metabolism of [ 14C]GSK977779 in rats and its implication with the observed covalent binding

Drug Metabolism and Disposition

Volumn 39, Issue 9, 2011, Pages 1620-1632

  Tsalta, Catherine D ^a   Madatian, Armina ^a   Schubert, Ernest M ^a   Xia, Fangming ^a   Hardesty, William M ^a   Deng, Yanli ^a   Seymour, Jennifer L ^a   Gorycki, Peter D ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,4 OXADIAZOLE DERIVATIVE; ANTILIPEMIC AGENT; CARBON 14; CARBOXYLIC ACID; DRUG METABOLITE; GSK 977779; PARACETAMOL; PLASMA PROTEIN; SKATOLE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE; CONTROLLED STUDY; COVALENT BOND; DEALKYLATION; DRUG ABSORPTION; DRUG CONJUGATION; DRUG DISPOSITION; DRUG ELIMINATION; DRUG OXIDATION; DRUG PROTEIN BINDING; DRUG TRANSFORMATION; FEMALE; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LOW DRUG DOSE; MALE; MASS SPECTROMETRY; NONHUMAN; OXYGENATION; PLASMA; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RADIOACTIVITY; RAT; SINGLE DRUG DOSE; SOLUBILIZATION; URINALYSIS;

ADMINISTRATION, ORAL; ANIMALS; BILE; BLOOD PROTEINS; CARBON RADIOISOTOPES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FECES; FEMALE; LIVER; MALE; MASS SPECTROMETRY; MICROSOMES, LIVER; OXADIAZOLES; PLASMA; PROTEIN BINDING; PURINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NICOTINIC;

RATTUS;

EID: 80052018322     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.110.036467     Document Type: Article

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