Endoplasmic reticulum microenvironment and conserved histidines govern ELOVL4 fatty acid elongase activity

Journal of Lipid Research

Volumn 55, Issue 4, 2014, Pages 698-708

  Logan, Sreemathi ^a,b   Agbaga, Martin Paul ^a,b   Chan, Michael D ^a,b   Brush, Richard S ^a,b   Anderson, Robert E ^a,b  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

Author keywords

Autosomal dominant; Elongation of very long chain fatty acids like 4; Lipid metabolism; Mutant; Retinal degeneration

Indexed keywords

ALANINE; CARBON; CELL PROTEIN; ELOVL4 PROTEIN; GLUTAMINE; HISTIDINE; UNCLASSIFIED DRUG; VERY LONG CHAIN FATTY ACID; ELOVL4 PROTEIN, MOUSE; EYE PROTEIN; FATTY ACID; MEMBRANE PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; ENDOPLASMIC RETICULUM; ENZYME ACTIVE SITE; ENZYME ACTIVITY; FATTY ACID CHAIN ELONGATION; FATTY ACID SYNTHESIS; LIPID COMPOSITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN GLYCOSYLATION; PROTEIN LOCALIZATION; PROTEIN MOTIF; SITE DIRECTED MUTAGENESIS; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; ENZYMOLOGY; GENE EXPRESSION; GENETICS; GLYCOSYLATION; HEK293 CELL LINE; HELA CELL LINE; HUMAN; METABOLISM; MOUSE; NUCLEOTIDE SEQUENCE; PROTEIN PROCESSING; PROTEIN TRANSPORT;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CATALYTIC DOMAIN; CONSERVED SEQUENCE; ENDOPLASMIC RETICULUM; EYE PROTEINS; FATTY ACIDS; GENE EXPRESSION; GLYCOSYLATION; HEK293 CELLS; HELA CELLS; HISTIDINE; HUMANS; MEMBRANE PROTEINS; MICE; MUTAGENESIS, SITE-DIRECTED; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT;

EID: 84897439387     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M045443     Document Type: Article

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