Long-lasting improved amino acid bioavailability associated with protein pulse feeding in hospitalized elderly patients: A randomized controlled trial

Nutrition

Volumn 30, Issue 5, 2014, Pages 544-550

  Bouillanne, Olivier ^a,b   Neveux, Nathalie ^b,c   Nicolis, Ioannis ^b   Curis, Emmanuel ^b   Cynober, Luc ^b,c   Aussel, Christian ^b,d  

^a Hôpitaux Universitaires Henri Mondor   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c HÔTEL DIEU   (France)

^d HENRI MONDOR HOSPITAL   (France)

Author keywords

Amino acids; Elderly; Malnutrition; Protein pulse feeding

Indexed keywords

ALANINE; AMINO ACID; ARGININE; ASPARAGINE; ASPARTIC ACID; CITRULLINE; CYSTEINE; ESSENTIAL AMINO ACID; GLUTAMIC ACID; GLUTAMINE; GLYCINE; HISTIDINE; ISOLEUCINE; LEUCINE; LYSINE; METHIONINE; NONESSENTIAL AMINO ACID; ORNITHINE; PHENYLALANINE; PROLINE; SERINE; TAURINE; THREONINE; TYROSINE; VALINE; PROTEIN INTAKE;

AGED; AMINO ACID BLOOD LEVEL; AMINO ACID METABOLISM; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; ELDERLY CARE; FEMALE; HOSPITAL PATIENT; HUMAN; MAJOR CLINICAL STUDY; MALE; MALNUTRITION; POSTPRANDIAL STATE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN DIET; RANDOMIZED CONTROLLED TRIAL; THERAPY EFFECT; VERY ELDERLY; ADMINISTRATION AND DOSAGE; AGING; BLOOD; CALORIC INTAKE; DIET; HOSPITALIZATION; MEAL; PHARMACOKINETICS; PHYSIOLOGY; PROTEIN INTAKE; SPLANCHNIC BLOOD FLOW;

AGED, 80 AND OVER; AGING; AMINO ACIDS; BIOLOGICAL AVAILABILITY; DIET; DIETARY PROTEINS; ENERGY INTAKE; FEMALE; HOSPITALIZATION; HUMANS; MALE; MEALS; POSTPRANDIAL PERIOD; PROSPECTIVE STUDIES; SPLANCHNIC CIRCULATION;

EID: 84897438954     PISSN: 08999007     EISSN: 18731244     Source Type: Journal    
DOI: 10.1016/j.nut.2013.10.006     Document Type: Article

References (36)

1. Walrand S., Guillet C., Salles J., Cano N., Boirie Y. Physiopathological mechanism of sarcopenia. Clin Geriatr Med 2011, 27:365-385.
2. Visser M., Schaap L.A. Consequences of sarcopenia. Clin Geriatr Med 2011, 27:387-399.
3. Janssen I., Baumgartner R.N., Ross R., Rosenberg I.H., Roubenoff R. Skeletal muscle cutpoints associated with elevated physical disability risk in older men and women. Am J Epidemiol 2004, 159:413-421.
4. Hébuterne X., Bermon S., Schneider S.M. Ageing and muscle: The effects of malnutrition, re-nutrition, and physical exercise. Curr Opin Clin Nutr Metab Care 2001, 4:295-300.
5. Katsanos C.S., Kobayashi H., Sheffield-Moore M., Aarsland A., Wolfe R.R. Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids. Am J Clin Nutr 2005, 82:1065-1073.
6. Symons T.B., Schutzler S.E., Cocke T.L., Chinkes D.L., Wolfe R.R., Paddon-Jones D. Aging does not impair the anabolic response to a protein-rich meal. Am J Clin Nutr 2007, 86:451-456.
7. Katsanos C.S., Kobayashi H., Sheffield-Moore M., Aarsland A., Wolfe R.R. A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly. Am J Physiol Endocrinol Metab 2006, 291:E381-E387.
8. Rieu I., Balage M., Sornet C., Giraudet C., Pujos E., Grizard J., et al. Leucine supplementation improves muscle protein synthesis in elderly men independently of hyperaminoacidaemia. J Physiol 2006, 575:305-315.
9. Verhoeven S., Vanschoonbeek K., Verdijk L.B., Koopman R., Wodzig W.K., Dendale P., et al. Long-term leucine supplementation does not increase muscle mass or strength in healthy elderly men. Am J Clin Nutr 2009, 89:1468-1475.
10. Boirie Y., Gachon P., Beaufrère B. Splanchnic and whole-body leucine kinetics in young and elderly men. Am J Clin Nutr 1997, 65:489-495.
11. Dangin M., Guillet C., Garcia-Rodenas C., Gachon P., Bouteloup-Demange C., Reiffers-Magnani K. The rate of protein digestion affects protein gain differently during aging in humans. J Physiol 2003, 549:635-644.
12. Arnal M., Mosoni L., Boirie Y., Houlier M.L., Morin L., Verdier E., et al. Protein pulse feeding improves protein retention in elderly women. Am J Clin Nutr 1999, 69:1202-1208.
13. Arnal M.A., Mosoni L., Dardevet D., Ribeyre M.C., Bayle G., Prugnaud J., et al. Pulse protein feeding pattern restores stimulation of muscle protein synthesis during the feeding period in old rats. J Nutr 2002, 132:1002-1008.
14. Boirie Y., Dangin M., Gachon P., Vasson M.P., Maubois J.L., Beaufrère B. Slow and fast dietary proteins differently modulate postprandial protein accretion. Proc Natl Acad Sci USA 1997, 94:14930-14935.
15. Bouillanne O., Curis E., Hamon-Vilcot B., Nicolis I., Chrétien P., Schauer N., et al. Impact of protein pulse feeding on lean mass in malnourished and at-risk hospitalized elderly patients: A randomized controlled trial. Clin Nutr 2013, 32:186-192.
16. Vellas B., Guigoz Y., Garry P.J., Nourhashemi F., Bennahum D., Lauque S., et al. The Mini Nutritional Assessment (MNA) and its use in grading the nutritional state of elderly patients. Nutrition 1999, 15:116-122.
17. Neveux N., David P., Cynober L. Measurement of amino acid concentration in biological fluids and tissues using ion-exchange chromatography. Metabolic and therapeutic aspects of amino acids in clinical nutrition 2004, 17-28. CRC Press, Boca Raton, FL. L. Cynober (Ed.).
18. Galecki A.T., Burzykowski T. Linear mixed- effects models using R: A step-by-step approach 2013, Springer-Verlag, New York.
19. Pinheiro J.C., Bates D.M. Mixed-effects models in S and S-PLUS 2000, 146-166. Springer-Verlag, New York.
20. Volpi E., Mittendorfer B., Wolf S.E., Wolfe R.R. Oral amino acids stimulate muscle protein anabolism in the elderly despite higher first-pass splanchnic extraction. Am J Physiol 1999, 277:E513-E520.
21. Polge A., Bancel E., Bellet H., Strubel D., Poirey S., Peray P., et al. Plasma amino acid concentrations in elderly patients with protein energy malnutrition. Age Ageing 1997, 26:457-462.
22. Matthews D.E., Marano M.A., Campbell R.G. Splanchnic bed utilization of glutamine and glutamic acid in humans. Am J Physiol 1993, 264:E848-E854.
23. Crenn P., Coudray-Lucas C., Thuillier F., Cynober L., Messing B. Postabsorptive plasma citrulline concentration is a marker of absorptive enterocyte mass and intestinal failure in humans. Gastroenterology 2000, 119:1496-1505.
24. Volpi E., Sheffield-Moore M., Rasmussen B., Wolfe R. Basal muscle amino acid kinetics and protein synthesis in healthy young and older men. JAMA 2001, 286:1206-1212.
25. Walrand S., Chambon-Savanovitch C., Felgines C., Chassagne J., Raul F., Normand B., et al. Aging: A barrier to renutrition? Nutritional and immunologic evidence in rats. Am J Clin Nutr 2000, 72:816-824.
26. Jourdan M., Deutz N.E.P., Cynober L., Aussel C. Features, causes and consequences of splanchnic sequestration of amino acid in old rats. PLoS One 2011, 11:e27002.
27. Volpi E., Ferrando A.A., Yeckel C.W., Tipton K.D., Wolfe R.R. Exogenous amino acids stimulate net muscle protein synthesis in the elderly. J Clin Invest 1998, 101:2000-2007.
28. Jourdan M., Cynober L., Moinard C., Blanc M.C., Neveux N., De Bandt J.P., et al. Splanchnic sequestration of amino acids in aged rats: Invivo and exvivo experiments using a model of isolated perfused liver. Am J Physiol Regul Integr Comp Physiol 2008, 294:R748-R755.
29. Volpi E., Kobayashi H., Sheffield-Moore M., Mittendorfer B., Wolfe R.R. Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults. Am J Clin Nutr 2003, 78:250-258.
30. Dillon E.L., Sheffield-Moore M., Paddon-Jones D., Gilkison C., Sanford A.P., Casperson S.L., et al. Amino acid supplementation increases lean body mass, basal muscle protein synthesis, and insulin-like growth factor-1 expression in older women. J Clin Endocrinol Metab 2009, 94:1630-1637.
31. Paddon-Jones D., Sheffield-Moore M., Zhang X.J., Volpi E., Wolf S.E., Aarsland A., et al. Amino acid ingestion improves muscle protein synthesis in the young and elderly. Am J Physiol Endocrinol Metab 2004, 286:E321-E328.
32. Giordano M., Castellino P., DeFronzo R.A. Differential responsiveness of protein synthesis and degradation to amino acid availability in humans. Diabetes 1996, 45:393-399.
33. Metges C.C., Barth C.A. Metabolic consequences of a high dietary-protein intake in adulthood: Assessment of the available evidence. J Nutr 2000, 130:886-889.
34. Péquignot R., Belmin J., Chauvelier S., Gaubert J.Y., Konrat C., Duron E., et al. Renal function in older hospital patients is more accurately estimated using the Cockcroft-Gault formula than the modification diet in renal disease formula. J Am Geriatr Soc 2009, 57:1638-1643.
35. Levey A.S., Greene T., Sarnak M.J., Wang X., Beck G.J., Kusek J.W., et al. Effect of dietary protein restriction on the progression of kidney disease: Long-term follow-up of the Modification of Diet in Renal Disease (MDRD) Study. Am J Kidney Dis 2006, 48:879-888.
36. Raynaud-Simon A., Revel-Delhom C., Hébuterne X. French Nutrition and Health Program, French Health High Authority. Clinical practice guidelines from the French Health High Authority: Nutritional support strategy in protein-energy malnutrition in the elderly. Clin Nutr 2011, 30:312-319.