Differential responsiveness of protein synthesis and degradation to amino acid availability in humans

Diabetes

Volumn 45, Issue 4, 1996, Pages 393-399

  Giordano, Mauro ^c   Castellino, Pietro ^c   DeFronzo, Ralph A ^a,b  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

^c SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; GROWTH HORMONE; INSULIN; PROTEIN; SOMATOMEDIN C;

ADULT; AMINO ACID BLOOD LEVEL; AMINO ACID METABOLISM; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; GROWTH HORMONE BLOOD LEVEL; HORMONAL REGULATION; HUMAN; HUMAN EXPERIMENT; INSULIN BLOOD LEVEL; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SYNTHESIS REGULATION; RANDOMIZED CONTROLLED TRIAL;

EID: 0029933506     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.45.4.393     Document Type: Article

References (30)

1. McNurlan MA, Garlick PJ: Influence of nutrient intake on protein turnover Diabetes Matab Rev 5:165-189, 1989
2. Motil JK, Matthews DE, Bier DM, Burke JF, Munro HN, Young VR. Whole-body leucine and lysine metabolism: response to dietary protein intake in young men. Am J Physiol 240:E712-E721, 1981
3. Clague MB, Keir MJ, Wright PD, Johnston IDA: The effects of nutrition and trauma on whole body protein metabolism in man. Clin Sci 65:165-175, 1983
4. Pacy PJ, Price GM, Halliday D, Quevedo MR, Millward DJ: Nitrogen homeostasis in man: the diurnal responses of protein synthesis and degradation and amino acid oxidation to diets with increasing protein intakes Clin Sci 80:103-118, 1994
5. Fulks RM, Li JB, Goldberg AL: Effects of insulin, glucose, and amino acids on protein turnover in rat diaphragm. J Biol Chem 250:200-298, 1975
6. Frayn KN, Maycock PF; Regulation of protein metabolism by a physiological concentration of insulin in mouse soleus and extensor digitorum longus muscles. Blochem J 184:323-330, 1979
7. Lundholm K, Schersten T. Protein synthesis in human skeletal muscle tissue: influence of insulin and amino acids. Eur J Clin Invest 7:531-530, 1977
8. Nissen S, Haymond MW: Changes in leucine kinetics during meal absorption: effects of dietary leucine availability. Am J Physiol 250 E695-E701, 1986
9. Young VR, Gucalp C, Rand WM, Matthews DE, Bier DM: Leucine kinetics during three weeks at submaintenance-to-maintenance intakes of leucine in men adaptation and accommodation. Hum Nutr Clin Nutr 41:1-18, 1987
10. 16N] lysine: response in healthy young men given excess energy intake. Metabolism 30:783-701, 1981
11. Aoki TT, Brennan MF, Muller WA, Soeldner JS, Alpert JS, Saltz SB, Kaufmann RL, Tan MH, Cahill GF: Amino acid levels across normal forearm muscle and splanchnic bed after a protein meal. Am J Clin Nutr 29:340-350, 1976
12. DeSanto NG, Capasso G, Anastasio P, Coppola S, Bellini L, Lombardi A: Brain-gut peptides and the renal hemodynamic response to an oral protein load: a study of gastrin. bombesin, and glucagon in man. Renal Physiol Biochem 15:53-56, 1992
13. Castellino P, Solini A, Luzi L, Ban JG, Smith DJ, Petrides A, Giordano M, Carroll C, DeFronzo RA: Glucose and amino acid metabolism in chronic renal failure: effect of insulin and amino acids. Am J Physiol 262:F168-F176, 1992
14. Tessan P, Inchiostro S, Biolo G, Trevisan R, Fantin G, Marescotti MC, Iori E, Tiengo A, Crepaldi G: Differential effects of hyperinsulinemia and hyperaminoacidemia on leucine-carbon metabolism in vivo. J Clin Invest 79.1062-1069, 1987
15. Simonson DC, DeFronzo RA: Indirect calorimetry: methodological and interpretive problems. Am J Physiol 258:E399-E412, 1990
16. Castellino P, Luzi L, Simonson DC, Haymond M, DeFronzo RA: Effect of insulin and plasma amino acid concentrations on leucine metabolism in man. J Clin Invest 80:178-1-1793, 1987
17. Nissen SL, VanHuisen C, Haymond MW: Measurements of branched chain amino acids and branched chained alpha-keto acids in plasma by high performance liquid chromatography. J Chromatogr 232:170-175, 1982
18. Daughaday WH, Mariz IK, Blethen SL: Inhibition of excess of bound somatomedin to membrane receptor and immunobinding sites: a comparison of radioreceptor and radioimmunoassay somatomedin in native and acid-ethanol extracted serum. J Clin Endocrinol Metab 51:781-788, 1980
19. Schwenk WF, Beaufrere B, Haymond MW: Use of reciprocal pool specific activities to model leucine metabolism in humans. Am J Physiol 249: E646-E6BO, 1985
20. Issekutz B, Paul P, Miller HI, Bortz WM: Oxidation of plasma FFA in lean and obese humans. Metabolism. 17:62-73, 1968
21. Clugston GA, Garlick PJ: The response of protein and energy metabolism to food intake in lean and obese man. Hum Nutr Clin Nutr 36C:57-70, 1982
22. Hoffer LJ, Yang RD, Matthews DE, Bistrian BR, Bier DM, Young VR: Effects of meal consumption on whole body leucine and alanine kinetics in young adult men. Br J Nutr 53:31-38, 1985
23. Conway JM, Marable NL, Bodwell CE: Whole-body leucine and energy metabolism in adult women. Eur J Clin Nutr 42:661-669, 1988
24. Bennet WM, Connacher AA, Scrimegeour CM, Rennie MJ: The effect of amino acid infusion on leg protein turnover assessment by 1-[1-13C]leucine exchange. Eur J Clin Invest 20:41-50, 1990
25. De Feo P, Gaisano MG, Hymond MW: Differential effects of insulin deficiency on albumin and fibrinogen synthesis in humans J Clin Incest 88:833-840, 1991
26. Fukagawa NK, Minaker KL, Young VR, Rowe JW: Insulin dose-dependent reductions in plasma amino acids in man. Am J Physiol 250:E13-E17, 1986
27. Horber FF, Haymond MW: Human growth hormone prevents the protein catabolic side effects of prednisone in humans. J Clin Invest 86:265-272, 1990
28. Turkalj I, Keller U, Ninnis R, Vosmeer S, Stauffacher W: Effect of increasing doses of recombinant insulin-like growth factor I on glucose, lipid and leucine metabolism in man. J Clin Endocrinol Metab 75:1180-1191, 1992
29. Goulet O, DePotter S, Salas J, Robert JJ, Rongier M, Ben Hariz M, Koziet J, Desjeux JF, Ricour C, Darmaun D: Leucine metabolism at graded amino acid intakes in children receiving parenteral nutrition. Am J Physiol 265:ES40-E546, 1993
30. Hoffer LJ, Bistrian BR, Young VR, Blackburn GL, Matthews DE: Metabolic effects of very low calorie weight reduction diets. J Clin Invest 73:750-758, 1984