Reduction in IL-33 plasma levels might be involved in T cell dysregulation in chronic lymphocytic leukemia

Acta Haematologica

Volumn 131, Issue 3, 2014, Pages 165-166

  Musolino, Caterina ^a   Allegra, Alessandro ^a,c   Profita, Mirella ^b   Alonci, Andrea ^a   Saitta, Salvatore ^a   Bonanno, Anna ^b   Gerace, Demetrio ^a   Calabrò, Laura ^a   Gangemi, Sebastiano ^a,b  

^a UNIVERSITY OF MESSINA   (Italy)

^b CNR Consiglio Nazionale delle Ricerche   (Italy)

^c UNIVERSITY OF MESSINA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD38 ANTIGEN; INTERLEUKIN 31; INTERLEUKIN 33; PROTEIN KINASE ZAP 70; CD20 ANTIGEN;

ANTIGEN EXPRESSION; ARTICLE; CHRONIC LYMPHATIC LEUKEMIA; HUMAN; IMMUNE DYSREGULATION; PRIORITY JOURNAL; T LYMPHOCYTE; TH1 TH2 BALANCE; CORRELATION ANALYSIS; DISEASE COURSE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETIC ANALYSIS; HUMAN EXPERIMENT; IMMUNE RESPONSE; IMMUNOPHENOTYPING; IMMUNOREGULATION; LYMPHOCYTE FUNCTION; PLEIOTROPY; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; T LYMPHOCYTE DYSREGULATION; TH2 CELL;

AGED; AGED, 80 AND OVER; ANTIGENS, CD20; ANTIGENS, CD3; CASE-CONTROL STUDIES; FEMALE; HUMANS; IMMUNE TOLERANCE; INTERLEUKINS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MALE; MIDDLE AGED; T-LYMPHOCYTES; TH2 CELLS; TUMOR MICROENVIRONMENT;

EID: 84897426267     PISSN: 00015792     EISSN: 14219662     Source Type: Journal    
DOI: 10.1159/000353476     Document Type: Article

References (9)

1. Gorgun G, Holderried TA, Zahrieh D, Neuberg D, Gribben JG: Chronic lymphocytic leukemia cells induce changes in gene expression of CD4 and CD8 T cells. J Clin Invest 2005; 115: 1797-1805.
2. Burger JA: Nurture versus nature: the microenvironment in chronic lymphocytic leukemia. Hematol Am Soc Hematol Educ Program 2011; 2011: 96-103.
3. Zhao W, Hu Z: The enigmatic processing and secretion of interleukin-33. Cell Mol Immunol 2010; 7: 260-262.
4. Ali S, Huber M, Kollewe C, Bischoff SC, Falk W, Martin MU: IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells. Proc Natl Acad Sci USA 2007; 104: 18660-18665.
5. Cornelissen C, Luscher-Firzlaff J, Baron JM, Luscher B: Signaling by IL-31 and functional consequences. Eur J Cell Biol 2012; 91: 552-566.
6. Musolino C, Allegra A, Profita M, Alonci A, Saitta S, Russo S, Bonanno A, Innao V, Gangemi S: Reduced IL-33 plasma levels in multiple myeloma patients are associated with more advanced stage of disease. Br J Haematol 2013; 160: 709-710.
7. Gangemi S, Allegra A, Profita M, Saitta S, Gerace D, Bonanno A, Alonci A, Petrungaro A, Russo S, Musolino C: Decreased plasma levels of IL-33 could contribute to the altered function of Th2 lymphocytes in patients with polycythemia vera and essential thrombocythemia. Cancer Invest 2013; 31: 212-213.
8. Podhorecka M, Dmoszynska A, Rolinski J, Wasik E: T type 1/type 2 subsets balance in Bcell chronic lymphocytic leukemia - the three-color flow cytometry analysis. Leuk Res 2002; 26: 657-660.
9. Huang L, Chen S, Zha X, Yang L, Li B, Yu Z, Wang L, Li Y: Expression feature of CD3, FcεRIγ, and Zap-70 in patients with chronic lymphocytic leukemia. Hematology 2012; 17: 71-75.