Synthesis and in vitro evaluation of 12-(substituted aminomethyl) berberrubine derivatives as anti-diabetics

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 7, 2014, Pages 1762-1765

  Li, Renjun ^a   Wu, Jianbo ^a   He, Yun ^a   Hai, Li ^a   Wu, Yong ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

12 (Substituted aminomethyl) berberrubine derivatives; Anti diabetic activity; Synthesis; Type 2 diabetes mellitus

Indexed keywords

ANTIDIABETIC AGENT; BERBERINE DERIVATIVE; INSULIN; ROSIGLITAZONE; ALKALOID; BERBERRUBINE DERIVATIVE; BERBINE DERIVATIVE; GLUCOSE; UNCLASSIFIED DRUG; BERBERINE; BEROLINE;

ANTIDIABETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; IN VITRO STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; ADIPOCYTE; DRUG STRUCTURE; GLUCOSE TRANSPORT; 3T3 CELL LINE; ANALOGS AND DERIVATIVES; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DIABETES MELLITUS, TYPE 2; DOSE RESPONSE; DRUG EFFECTS; INSULIN RESISTANCE; MOUSE; PATHOLOGY; RAT; SKELETAL MUSCLE; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; BERBERINE; DIABETES MELLITUS, TYPE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOSE; HYPOGLYCEMIC AGENTS; INSULIN RESISTANCE; MICE; MOLECULAR STRUCTURE; MUSCLE FIBERS, SKELETAL; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84897421583     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.02.032     Document Type: Article

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