Design, synthesis, crystallographic studies, and preliminary biological appraisal of new substituted triazolo[4,3-b]pyridazin-8-amine derivatives as tankyrase inhibitors

Journal of Medicinal Chemistry

Volumn 57, Issue 6, 2014, Pages 2807-2812

  Liscio, Paride ^a,d   Carotti, Andrea ^a   Asciutti, Stefania ^b   Karlberg, Tobias ^c   Bellocchi, Daniele ^a   Llacuna, Laura ^b   Macchiarulo, Antonio ^a   Aaronson, Stuart A ^b   Schüler, Herwig ^c   Pellicciari, Roberto ^a,d   Camaioni, Emidio ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c KAROLINSKA INSTITUTE   (Sweden)

^d TES Pharma   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4(2(6 METHYL [1,2,4 TRIAZOLO [4,3 B] PYRIDAZIN 8 YLAMINO) ETHYL) PHENOL; 6 ALKYL [1,2,4] TRIAZOLO[4,3 B] PYRIDAZINE DERIVATIVE; AMINE; METHYL GROUP; NICOTINAMIDE ADENINE DINUCLEOTIDE; NITROGEN; OLAPARIB; TANKYRASE; TRIAZOLO [4,3 B ] PYRIDAZIN 8 AMINE DERIVATIVE; TRIAZOLOPYRIDAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CRYSTALLOGRAPHY; DRUG DESIGN; DRUG SYNTHESIS; ENZYME BINDING; ENZYME INHIBITION; HUMAN; IC 50; STRUCTURE ACTIVITY RELATION;

ADENOSINE DIPHOSPHATE RIBOSE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; INDICATORS AND REAGENTS; LUCIFERASES; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PYRIDAZINES; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TANKYRASES; TRIAZOLES;

EID: 84897418380     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401356t     Document Type: Article

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