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Volumn 22, Issue 7, 2014, Pages 2052-2059

Fused heterocyclic compounds bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 1: Design, synthesis and biological evaluation of novel 5,7-disubstituted pyrazolo[1,5-a]pyrimidine derivatives

(9) Tian, Ye a Du, Deping a Rai, Diwakar a Wang, Liu a Liu, Huiqing a Zhan, Peng a De Clercq, Erik b Pannecouque, Christophe b Liu, Xinyong a

a SHANDONG UNIVERSITY (China)

b REGA INSTITUTE FOR MEDICAL RESEARCH (Belgium)

Author keywords

Activity assay; Heterocycle; HIV 1; Molecular modeling; NNRTIs; Pyrazolo 1,5 a pyrimidine; RT; Synthesis

Indexed keywords

4 [5 (4 BROMOPHENYLAMINO)PYRAZOLO[1,5 A]PYRIMIDIN 7YLOXY] 3,5 DIMETHYLBENZONITRILE; 4 [5 (4 CHLOROPHENYLAMINO)PYRAZOLO[1,5 A]PYRIMIDIN 7YLOXY] 3,5 DIMETHYLBENZONITRILE; 4 [5 (4 CYANOPHENYLAMINO)PYRAZOLO[1,5 A]PYRIMIDIN 7YLOXY] 3,5 DIMETHYLBENZONITRILE; 4 [5 (4 FLUOROPHENYLAMINO)PYRAZOLO[1,5 A]PYRIMIDIN 7YLOXY] 3,5 DIMETHYLBENZONITRILE; 4 [5 (4 METHOXYPHENYLAMINO)PYRAZOLO[1,5 A]PYRIMIDIN 7YLOXY] 3,5 DIMETHYLBENZONITRILE; 4 [5 (4 METHYLPHENYLAMINO)PYRAZOLO[1,5 A]PYRIMIDIN 7YLOXY] 3,5 DIMETHYLBENZONITRILE; 4 [5 (4 NITROPHENYLAMINO)PYRAZOLO[1,5 A]PYRIMIDIN 7YLOXY] 3,5 DIMETHYLBENZONITRILE; 4 [7 (2,4,6 TRIFLUOROPHENOXY)PYRAZOLO[1,5 A]PYRIMIDIN 5 YLAMINO]BENZONITRILE; 4 [7 (2,6 DIMETHYLPHENOXY)PYRAZOLO[1,5 A]PYRIMIDIN 5 YLAMINO]BENZONITRILE; 4 [7 (3,5 DIMETHYLPHENOXY)PYRAZOLO[1,5 A]PYRIMIDIN 5 YLAMINO]BENZONITRILE; 4 [7 (4 BROMO 2,6 DIMETHYLPHENOXY)PYRAZOLO[1,5 A]PYRIMIDIN 5 YLAMINO]BENZONITRILE; 4 [7 (MESITYLOXY)PYRAZOLO[1,5 A]PYRIMIDIN 5 YLAMINO]BENZONITRILE; 7 (MESITYLOXY) N (4 METHOXYPHENYL)PYRAZOLO[1,5 A]PYRIMIDIN 5 AMINE; 7 (MESITYLOXY) N (4 NITROPHENYL)PYRAZOLO[1,5 A]PYRIMIDIN 5 AMINE; 7 (MESITYLOXY) N P TOLYLPYRAZOLO[1,5 A]PYRIMIDIN 5 AMINE; DELAVIRDINE; FUSED HETEROCYCLIC RINGS; N, (4 BROMOPHENYL) 7 (MESITYLOXY)PYRAZOLO[1,5 A]PYRIMIDIN 5 AMINE; N, (4 CHLOROPHENYL) 7 (MESITYLOXY)PYRAZOLO[1,5 A]PYRIMIDIN 5 AMINE; N, (4 FLUOROPHENYL) 7 (MESITYLOXY)PYRAZOLO[1,5 A]PYRIMIDIN 5 AMINE; NEVIRAPINE; NITROGEN; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; HETEROCYCLIC COMPOUND; PYRAZOLE DERIVATIVE; PYRAZOLO(1,5-A)PYRIMIDINE; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR;

ARTICLE; CELL CULTURE; DRUG ACTIVITY; DRUG BINDING; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR MODEL; NONHUMAN; WILD TYPE; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; HUMAN IMMUNODEFICIENCY VIRUS; METABOLISM; MICROBIAL SENSITIVITY TEST; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ANTI-HIV AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HETEROCYCLIC COMPOUNDS; HIV; HIV REVERSE TRANSCRIPTASE; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NITROGEN; PYRAZOLES; PYRIMIDINES; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84897415957 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2014.02.029 Document Type: Article

Times cited : (86)

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