메뉴 건너뛰기




Volumn 85, Issue 4, 2014, Pages 581-591

Clinical and microbiologic effects of adjunctive metronidazole plus amoxicillin in the treatment of generalized chronic periodontitis: Smokers versus non-smokers

Author keywords

Amoxicillin; Chronic periodontitis; Metronidazole; Nonsurgical periodontal debridement; Smoking.

Indexed keywords

AMOXICILLIN; ANTIINFECTIVE AGENT; METRONIDAZOLE;

EID: 84897414701     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2013.130278     Document Type: Article
Times cited : (31)

References (50)
  • 1
    • 0033071635 scopus 로고    scopus 로고
    • Cigarette smoking and periodontitis: Methodology to assess the strength of evidence in support of a causal association
    • Gelskey SC. Cigarette smoking and periodontitis: Methodology to assess the strength of evidence in support of a causal association. Community Dent Oral Epidemiol 1999;27:16-24.
    • (1999) Community Dent Oral Epidemiol , vol.27 , pp. 16-24
    • Gelskey, S.C.1
  • 3
    • 34247631302 scopus 로고    scopus 로고
    • The impact of cigarette smoking on periodontal disease and treatment
    • Johnson GK, Guthmiller JM. The impact of cigarette smoking on periodontal disease and treatment. Periodontol 2000 2007;44:178-194.
    • (2000) Periodontol , vol.2007 , Issue.44 , pp. 178-194
    • Johnson, G.K.1    Guthmiller, J.M.2
  • 5
    • 8344222712 scopus 로고    scopus 로고
    • Periodontal attachment loss attributable to cigarette smoking in an urban Brazilian population
    • Susin C, Oppermann RV, Haugejorden O, Albandar JM. Periodontal attachment loss attributable to cigarette smoking in an urban Brazilian population. J Clin Periodontol 2004;31:951-958.
    • (2004) J Clin Periodontol , vol.31 , pp. 951-958
    • Susin, C.1    Oppermann, R.V.2    Haugejorden, O.3    Albandar, J.M.4
  • 6
    • 0029201547 scopus 로고
    • Assessment of risk for periodontal disease. II. Risk indicators for alveolar bone loss
    • Grossi SG, Genco RJ, Machtei EE, et al. Assessment of risk for periodontal disease. II. Risk indicators for alveolar bone loss. J Periodontol 1995;66:23-29.
    • (1995) J Periodontol , vol.66 , pp. 23-29
    • Grossi, S.G.1    Genco, R.J.2    Machtei, E.E.3
  • 8
    • 0024743564 scopus 로고
    • Cigarette smoking as risk factor in chronic periodontal disease
    • Bergström J. Cigarette smoking as risk factor in chronic periodontal disease. Community Dent Oral Epidemiol 1989;17:245-247.
    • (1989) Community Dent Oral Epidemiol , vol.17 , pp. 245-247
    • Bergström, J.1
  • 9
    • 0033251978 scopus 로고    scopus 로고
    • The prevalence of BANA-hydrolyzing periodontopathic bacteria in smokers
    • Kazor C, Taylor GW, Loesche WJ. The prevalence of BANA-hydrolyzing periodontopathic bacteria in smokers. J Clin Periodontol 1999;26:814-821.
    • (1999) J Clin Periodontol , vol.26 , pp. 814-821
    • Kazor, C.1    Taylor, G.W.2    Loesche, W.J.3
  • 10
    • 0035347684 scopus 로고    scopus 로고
    • Relationship of cigarette smoking to the subgingival microbiota
    • Haffajee AD, Socransky SS. Relationship of cigarette smoking to the subgingival microbiota. J Clin Periodontol 2001;28:377-388.
    • (2001) J Clin Periodontol , vol.28 , pp. 377-388
    • Haffajee, A.D.1    Socransky, S.S.2
  • 11
    • 57349136703 scopus 로고    scopus 로고
    • The effect of a supragingival plaque-control regimen on the subgingival microbiota in smokers and never-smokers: Evaluation by real-time polymerase chain reaction
    • Gomes SC, Nonnenmacher C, Susin C, Oppermann RV, Mutters R, Marcantonio RA. The effect of a supragingival plaque-control regimen on the subgingival microbiota in smokers and never-smokers: Evaluation by real-time polymerase chain reaction. J Periodontol 2008;79:2297-2304.
    • (2008) J Periodontol , vol.79 , pp. 2297-2304
    • Gomes, S.C.1    Nonnenmacher, C.2    Susin, C.3    Oppermann, R.V.4    Mutters, R.5    Marcantonio, R.A.6
  • 12
    • 33750115389 scopus 로고    scopus 로고
    • Periodontal status in smokers and never-smokers: Clinical findings and real-time polymerase chain reaction quantification of putative periodontal pathogens
    • Gomes SC, Piccinin FB, Oppermann RV, et al. Periodontal status in smokers and never-smokers: Clinical findings and real-time polymerase chain reaction quantification of putative periodontal pathogens. J Periodontol 2006;77:1483-1490.
    • (2006) J Periodontol , vol.77 , pp. 1483-1490
    • Gomes, S.C.1    Piccinin, F.B.2    Oppermann, R.V.3
  • 13
    • 84865593077 scopus 로고    scopus 로고
    • Smoking and the subgingival ecosystem: A pathogen-enriched community
    • Kumar PS. Smoking and the subgingival ecosystem: A pathogen-enriched community. Future Microbiol 2012;7:917-919.
    • (2012) Future Microbiol , vol.7 , pp. 917-919
    • Kumar, P.S.1
  • 14
    • 0032184988 scopus 로고    scopus 로고
    • Clinical expression of TNF-alpha in smoking-associated periodontal disease
    • Boström L, Linder LE, Bergström J. Clinical expression of TNF-alpha in smoking-associated periodontal disease. J Clin Periodontol 1998;25:767-773.
    • (1998) J Clin Periodontol , vol.25 , pp. 767-773
    • Boström, L.1    Linder, L.E.2    Bergström, J.3
  • 15
    • 0033142522 scopus 로고    scopus 로고
    • Smoking and cervicular fluid levels of IL-6 and TNF-alpha in periodontal disease
    • Boström L, Linder LE, Bergström J. Smoking and cervicular fluid levels of IL-6 and TNF-alpha in periodontal disease. J Clin Periodontol 1999;26:352-357.
    • (1999) J Clin Periodontol , vol.26 , pp. 352-357
    • Boström, L.1    Linder, L.E.2    Bergström, J.3
  • 16
    • 0036562186 scopus 로고    scopus 로고
    • Granulocyte elastase matrix metalloproteinase-8 and prostaglandin E2 in gingival crevicular fluid in matched clinical sites in smokers and non-smokers with persistent periodontitis
    • Söder B, Jin LJ, Wickholm S. Granulocyte elastase, matrix metalloproteinase-8 and prostaglandin E2 in gingival crevicular fluid in matched clinical sites in smokers and non-smokers with persistent periodontitis. J Clin Periodontol 2002;29:384-391.
    • (2002) J Clin Periodontol , vol.29 , pp. 384-391
    • Söder, B.1    Jin, L.J.2    Wickholm, S.3
  • 17
    • 0036481173 scopus 로고    scopus 로고
    • IL-8 and TNF-alpha from peripheral neutrophils and acutephase proteins in periodontitis
    • Fredriksson M, Bergström K, Asman B. IL-8 and TNF-alpha from peripheral neutrophils and acutephase proteins in periodontitis. J Clin Periodontol 2002;29:123-128.
    • (2002) J Clin Periodontol , vol.29 , pp. 123-128
    • Fredriksson, M.1    Bergström, K.2    Asman, B.3
  • 18
    • 0029443949 scopus 로고
    • Periodontal healing and periopathogenic microflora in smokers and nonsmokers
    • Preber H, Linder L, Bergström J. Periodontal healing and periopathogenic microflora in smokers and nonsmokers. J Clin Periodontol 1995;22:946-952.
    • (1995) J Clin Periodontol , vol.22 , pp. 946-952
    • Preber, H.1    Linder, L.2    Bergström, J.3
  • 19
    • 0030183665 scopus 로고    scopus 로고
    • Levels of cigarette consumption and response to periodontal therapy
    • Kaldahl WB, Johnson GK, Patil KD, Kalkwarf KL. Levels of cigarette consumption and response to periodontal therapy. J Periodontol 1996;67:675-681.
    • (1996) J Periodontol , vol.67 , pp. 675-681
    • Kaldahl, W.B.1    Johnson, G.K.2    Patil, K.D.3    Kalkwarf, K.L.4
  • 20
    • 0031989103 scopus 로고    scopus 로고
    • The clinical and microbiological effects of non-surgical periodontal therapy in smokers and non-smokers
    • Renvert S, Dahlén G, Wikström M. The clinical and microbiological effects of non-surgical periodontal therapy in smokers and non-smokers. J Clin Periodontol 1998;25:153-157.
    • (1998) J Clin Periodontol , vol.25 , pp. 153-157
    • Renvert, S.1    Dahlén, G.2    Wikström, M.3
  • 21
    • 0034570348 scopus 로고    scopus 로고
    • Comparison of treatment response patterns following scaling and root planing in smokers and non-smokers with untreated adult periodontitis
    • Jin L, Wong KY, Leung WK, Corbet EF. Comparison of treatment response patterns following scaling and root planing in smokers and non-smokers with untreated adult periodontitis. J Clin Dent 2000;11: 35-41.
    • (2000) J Clin Dent , vol.11 , pp. 35-41
    • Jin, L.1    Wong, K.Y.2    Leung, W.K.3    Corbet, E.F.4
  • 22
    • 60249088082 scopus 로고    scopus 로고
    • Effects of smoking on healing response to non-surgical periodontal therapy: A multilevel modelling analysis
    • Wan CP, Leung WK, Wong MC, et al. Effects of smoking on healing response to non-surgical periodontal therapy: A multilevel modelling analysis. J Clin Periodontol 2009;36:229-239.
    • (2009) J Clin Periodontol , vol.36 , pp. 229-239
    • Wan, C.P.1    Leung, W.K.2    Wong, M.C.3
  • 23
    • 0037646912 scopus 로고    scopus 로고
    • Impaired healing response of periodontal furcation defects following flap debridement surgery in smokers. A controlled clinical trial
    • Trombelli L, Cho KS, Kim CK, Scapoli C, Scabbia A. Impaired healing response of periodontal furcation defects following flap debridement surgery in smokers. A controlled clinical trial. J Clin Periodontol 2003;30:81-87.
    • (2003) J Clin Periodontol , vol.30 , pp. 81-87
    • Trombelli, L.1    Cho, K.S.2    Kim, C.K.3    Scapoli, C.4    Scabbia, A.5
  • 24
    • 3543015035 scopus 로고    scopus 로고
    • Effect of periodontal therapy in smokers and non-smokers with advanced periodontal disease: Results after maintenance therapy for a minimum of 5 years
    • Papantonopoulos GH. Effect of periodontal therapy in smokers and non-smokers with advanced periodontal disease: Results after maintenance therapy for a minimum of 5 years. J Periodontol 2004;75: 839-843.
    • (2004) J Periodontol , vol.75 , pp. 839-843
    • Papantonopoulos, G.H.1
  • 25
    • 14844365452 scopus 로고    scopus 로고
    • Systematic review of the effect of smoking on nonsurgical periodontal therapy
    • Labriola A, Needleman I, Moles DR. Systematic review of the effect of smoking on nonsurgical periodontal therapy. Periodontol 2000 2005;37:124-137.
    • (2000) Periodontol , vol.2005 , Issue.37 , pp. 124-137
    • Labriola, A.1    Needleman, I.2    Moles, D.R.3
  • 27
    • 84861094271 scopus 로고    scopus 로고
    • Control of periodontal infections: A randomized controlled trial 1. The primary outcome attachment gain and pocket depth reduction at treated sites
    • Goodson JM, Haffajee AD, Socransky SS, et al. Control of periodontal infections: A randomized controlled trial I. The primary outcome attachment gain and pocket depth reduction at treated sites. J Clin Periodontol 2012;39:526-536.
    • (2012) J Clin Periodontol , vol.39 , pp. 526-536
    • Goodson, J.M.1    Haffajee, A.D.2    Socransky, S.S.3
  • 28
    • 77649211628 scopus 로고    scopus 로고
    • Microbiologic testing and outcomes of full-mouth scaling and root planing with or without amoxicillin/ metronidazole in chronic periodontitis
    • Cionca N, Giannopoulou C, Ugolotti G, Mombelli A. Microbiologic testing and outcomes of full-mouth scaling and root planing with or without amoxicillin/ metronidazole in chronic periodontitis. J Periodontol 2010;81:15-23.
    • (2010) J Periodontol , vol.81 , pp. 15-23
    • Cionca, N.1    Giannopoulou, C.2    Ugolotti, G.3    Mombelli, A.4
  • 29
    • 80051781995 scopus 로고    scopus 로고
    • Clinical and microbiological benefits of metronidazole alone or with amoxicillin as adjuncts in the treatment of chronic periodontitis: A randomized placebo-controlled clinical trial
    • Silva MP, Feres M, Sirotto TA, et al. Clinical and microbiological benefits of metronidazole alone or with amoxicillin as adjuncts in the treatment of chronic periodontitis: A randomized placebo-controlled clinical trial. J Clin Periodontol 2011;38:828-837.
    • (2011) J Clin Periodontol , vol.38 , pp. 828-837
    • Silva, M.P.1    Feres, M.2    Sirotto, T.A.3
  • 30
    • 84869502574 scopus 로고    scopus 로고
    • Metronidazole alone or with amoxicillin as adjuncts to nonsurgical treatment of chronic periodontitis: A 1-year double-blinded, placebo-controlled, randomized clinical trial
    • Feres M, Soares GM, Mendes JA, et al. Metronidazole alone or with amoxicillin as adjuncts to nonsurgical treatment of chronic periodontitis: A 1-year double-blinded, placebo-controlled, randomized clinical trial. J Clin Periodontol 2012;39:1149-1158.
    • (2012) J Clin Periodontol , vol.39 , pp. 1149-1158
    • Feres, M.1    Soares, G.M.2    Mendes, J.A.3
  • 31
    • 51749102672 scopus 로고    scopus 로고
    • Clinical and microbiological benefits of systemic metronidazole and amoxicillin in the treatment of smokers with chronic periodontitis: A randomized placebo-controlled study
    • Matarazzo F, Figueiredo LC, Cruz SE, Faveri M, Feres M. Clinical and microbiological benefits of systemic metronidazole and amoxicillin in the treatment of smokers with chronic periodontitis: A randomized placebo-controlled study. J Clin Periodontol 2008;35:885-896.
    • (2008) J Clin Periodontol , vol.35 , pp. 885-896
    • Matarazzo, F.1    Figueiredo, L.C.2    Cruz, S.E.3    Faveri, M.4    Feres, M.5
  • 32
    • 0033288546 scopus 로고    scopus 로고
    • Development of a classification system for periodontal diseases and conditions
    • Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol 1999;4:1-6.
    • (1999) Ann Periodontol , vol.4 , pp. 1-6
    • Armitage, G.C.1
  • 34
    • 77949769804 scopus 로고    scopus 로고
    • Short-term benefits of the adjunctive use of metronidazole plus amoxicillin in the microbial profile and in the clinical parameters of subjects with generalized aggressive periodontitis
    • Mestnik MJ, Feres M, Figueiredo LC, Duarte PM, Lira EA, Faveri M. Short-term benefits of the adjunctive use of metronidazole plus amoxicillin in the microbial profile and in the clinical parameters of subjects with generalized aggressive periodontitis. J Clin Periodontol 2010;37:353-365.
    • (2010) J Clin Periodontol , vol.37 , pp. 353-365
    • Mestnik, M.J.1    Feres, M.2    Figueiredo, L.C.3    Duarte, P.M.4    Lira, E.A.5    Faveri, M.6
  • 36
    • 0026248171 scopus 로고
    • Relation of counts of microbial species to clinical status at the sampled site
    • Socransky SS, Haffajee AD, Smith C, Dibart S. Relation of counts of microbial species to clinical status at the sampled site. J Clin Periodontol 1991; 18:766-775.
    • (1991) J Clin Periodontol , vol.18 , pp. 766-775
    • Socransky, S.S.1    Haffajee, A.D.2    Smith, C.3    Dibart, S.4
  • 37
    • 0347692610 scopus 로고    scopus 로고
    • Periodontal risk assessment (PRA) for patients in supportive periodontal therapy (SPT
    • Lang NP, Tonetti MS. Periodontal risk assessment (PRA) for patients in supportive periodontal therapy (SPT). Oral Health Prev Dent 2003;1:7-16.
    • (2003) Oral Health Prev Dent , vol.1 , pp. 7-16
    • Lang, N.P.1    Tonetti, M.S.2
  • 39
    • 74049086531 scopus 로고    scopus 로고
    • Significance of periodontal risk assessment in the recurrence of periodontitis and tooth loss
    • Matuliene G, Studer R, Lang NP, et al. Significance of periodontal risk assessment in the recurrence of periodontitis and tooth loss. J Clin Periodontol 2010; 37:191-199.
    • (2010) J Clin Periodontol , vol.37 , pp. 191-199
    • Matuliene, G.1    Studer, R.2    Lang, N.P.3
  • 40
    • 34247869713 scopus 로고    scopus 로고
    • The efficacy of non-surgical and systemic antibiotic treatment on smoking and non-smoking periodontitis patients
    • Pahkla ER, Koppel T, Naaber P, Saag M, Loivukene K. The efficacy of non-surgical and systemic antibiotic treatment on smoking and non-smoking periodontitis patients. Stomatologija 2006;8:116-121.
    • (2006) Stomatologija , vol.8 , pp. 116-121
    • Pahkla, E.R.1    Koppel, T.2    Naaber, P.3    Saag, M.4    Loivukene, K.5
  • 41
    • 0032060740 scopus 로고    scopus 로고
    • The use of metronidazole and amoxicillin in the treatment of advanced periodontal disease. A prospective, controlled clinical trial
    • Berglundh T, Krok L, Liljenberg B, Westfelt E, Serino G, Lindhe J. The use of metronidazole and amoxicillin in the treatment of advanced periodontal disease. A prospective, controlled clinical trial. J Clin Periodontol 1998;25:354-362.
    • (1998) J Clin Periodontol , vol.25 , pp. 354-362
    • Berglundh, T.1    Krok, L.2    Liljenberg, B.3    Westfelt, E.4    Serino, G.5    Lindhe, J.6
  • 43
    • 33747835523 scopus 로고    scopus 로고
    • Microbiological goals of periodontal therapy
    • Teles RP, Haffajee AD, Socransky SS. Microbiological goals of periodontal therapy. Periodontol 2000 2006;42:180-218.
    • (2000) Periodontol , vol.2006 , Issue.42 , pp. 180-218
    • Teles, R.P.1    Haffajee, A.D.2    Socransky, S.S.3
  • 44
    • 79551667028 scopus 로고    scopus 로고
    • Effect of nicotine, cotinine and cigarette smoke extract on the neutrophil respiratory burst
    • Matthews JB, Chen FM, Milward MR, et al. Effect of nicotine, cotinine and cigarette smoke extract on the neutrophil respiratory burst. J Clin Periodontol 2011; 38:208-218.
    • (2011) J Clin Periodontol , vol.38 , pp. 208-218
    • Matthews, J.B.1    Chen, F.M.2    Milward, M.R.3
  • 45
    • 33646502568 scopus 로고    scopus 로고
    • Effect of smoking on crevicular polymorphonuclear neutrophil function in periodontally healthy subjects
    • Güntsch A, Erler M, Preshaw PM, Sigusch BW, Klinger G, Glockmann E. Effect of smoking on crevicular polymorphonuclear neutrophil function in periodontally healthy subjects. J Periodontal Res 2006;41:184-188.
    • (2006) J Periodontal Res , vol.41 , pp. 184-188
    • Güntsch, A.1    Erler, M.2    Preshaw, P.M.3    Sigusch, B.W.4    Klinger, G.5    Glockmann, E.6
  • 47
    • 0029445876 scopus 로고
    • Effects of nicotine on proliferation and extracellular matrix production of human gingival fibroblasts in vitro
    • Tipton DA, Dabbous MK. Effects of nicotine on proliferation and extracellular matrix production of human gingival fibroblasts in vitro. J Periodontol 1995;66:1056-1064.
    • (1995) J Periodontol , vol.66 , pp. 1056-1064
    • Tipton, D.A.1    Dabbous, M.K.2
  • 48
    • 39049101476 scopus 로고    scopus 로고
    • Nicotine involved in periodontal disease through influence on cytokine levels
    • Makino A, Yamada S, Okuda K, Kato T. Nicotine involved in periodontal disease through influence on cytokine levels. FEMS Immunol Med Microbiol 2008; 52:282-286.
    • (2008) FEMS Immunol Med Microbiol , vol.52 , pp. 282-286
    • Makino, A.1    Yamada, S.2    Okuda, K.3    Kato, T.4
  • 49
    • 84857842391 scopus 로고    scopus 로고
    • The effect of smoking on the bioavailability of metronidazole in plasma and saliva
    • Montalli VA, Bergamaschi Cde C, Ramacciato JC, et al. The effect of smoking on the bioavailability of metronidazole in plasma and saliva. J Am Dent Assoc 2012;143:149-156.
    • (2012) J Am Dent Assoc , vol.143 , pp. 149-156
    • Montalli, V.A.1    Bergamaschi Cde, C.2    Ramacciato, J.C.3
  • 50
    • 14844290295 scopus 로고    scopus 로고
    • Metronidazole concentrations in plasma, saliva and periodontal pockets in patients with periodontitis
    • Pähkla ER, Koppel T, Saag M, Pähkla R. Metronidazole concentrations in plasma, saliva and periodontal pockets in patients with periodontitis. J Clin Periodontol 2005;32:163-166.
    • (2005) J Clin Periodontol , vol.32 , pp. 163-166
    • Pähkla, E.R.1    Koppel, T.2    Saag, M.3    Pähkla, R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.