Interleukin-15 and soluble interleukin-15 receptor α in coronary artery disease patients: Association with epicardial fat and indices of adipose tissue distribution

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Dozio, Elena ^a   Malavazos, Alexis Elias ^b   Vianello, Elena ^a   Briganti, Silvia ^b   Dogliotti, Giada ^a,c   Bandera, Francesco ^b   Giacomazzi, Francesca ^b   Castelvecchio, Serenella ^b   Menicanti, Lorenzo ^b   Sigrüener, Alexander ^c   Schmitz, Gerd ^c   Corsi Romanelli, Massimiliano Marco ^a,b  

^a UNIVERSITY OF MILAN   (Italy)

^b IRCCS POLICLINICO SAN DONATO   (Italy)

^c UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 15; INTERLEUKIN 15 RECEPTOR ALPHA; RNA; IL15 PROTEIN, HUMAN;

ADIPOSE TISSUE; ADULT; AGED; ARTICLE; BODY MASS; CORONARY ARTERY DISEASE; ECHOCARDIOGRAPHY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPICARDIAL ADIPOSE TISSUE; FEMALE; GENE EXPRESSION; HEART MUSCLE; HUMAN; HUMAN TISSUE; IMMUNOASSAY; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; OBESITY; PROTEIN BLOOD LEVEL; RNA EXTRACTION; THICKNESS; TISSUE DISTRIBUTION; VERY ELDERLY; WAIST CIRCUMFERENCE; WAIST HIP RATIO; ATHEROSCLEROTIC PLAQUE; BLOOD; BODY FAT DISTRIBUTION; CORONARY BLOOD VESSEL; GENETICS; INTRAABDOMINAL FAT; METABOLISM; PATHOLOGY; PERICARDIUM; SIGNAL TRANSDUCTION;

ADIPOSITY; AGED; AGED, 80 AND OVER; BODY FAT DISTRIBUTION; CORONARY ARTERY DISEASE; CORONARY VESSELS; FEMALE; GENE EXPRESSION; HUMANS; INTERLEUKIN-15; INTERLEUKIN-15 RECEPTOR ALPHA SUBUNIT; INTRA-ABDOMINAL FAT; MALE; MIDDLE AGED; PERICARDIUM; PLAQUE, ATHEROSCLEROTIC; SIGNAL TRANSDUCTION;

EID: 84897387470     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0090960     Document Type: Article

References (32)

1. Fehniger TA, Caligiuri MA (2001) Interleukin 15: biology and relevance to human disease. Blood 97: 14-32. (Pubitemid 32061238)
2. Giri JG, Ahdieh M, Eisenman J, Shanebeck K, Grabstein K, et al. (1994) Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15. EMBO J 13: 2822-2830. (Pubitemid 24191692)
3. Dubois S, Magrangeas F, Lehours P, Raher S, Bernard J, et al. (1999) Natural splicing of exon 2 of human interleukin-15 receptor alpha-chain mRNA results in a shortened form with a distinct pattern of expression. J Biol Chem 274: 26978-26984.
4. Dubois S, Mariner J, Waldmann TA, Tagaya Y (2002) IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells. Immunity 17: 537-547. (Pubitemid 35351500)
5. Mortier E, Bernard J, Plet A, Jacques Y (2004) Natural, proteolytic release of a soluble form of human IL-15 receptor alpha-chain that behaves as a specific, high affinity IL-15 antagonist. J Immunol 173: 1681-1688. (Pubitemid 38971599)
6. Bergamaschi C, Rosati M, Jalah R, Valentin A, Kulkarni V, et al. (2008) Intracellular interaction of interleukin-15 with its receptor alpha during production leads to mutual stabilization and increased bioactivity. J Biol Chem 283: 4189-4199.
7. Machado Diaz AC, Chico Capote A, Arrieta Aguero CA, Rodriguez Alvarez Y, Garcia Del Barco Herrera D, et al. (2012) Proinflammatory soluble interleukin-15 receptor alpha is increased in rheumatoid arthritis. Arthritis 2012: 943156.
8. Houtkamp MA, van Der Wal AC, de Boer OJ, van Der Loos CM, de Boer PA, et al. (2001) Interleukin-15 expression in atherosclerotic plaques: an alternative pathway for T-cell activation in atherosclerosis? Arterioscler Thromb Vasc Biol 21: 1208-1213. (Pubitemid 34215152)
9. Kaibe M, Ohishi M, Ito N, Yuan M, Takagi T, et al. (2005) Serum interleukin-15 concentration in patients with essential hypertension. Am J Hypertens 18: 1019-1025. (Pubitemid 41139898)
10. Gokkusu C, Aydin M, Ozkok E, Tulubas F, Elitok A, et al. (2010) Influences of genetic variants in interleukin-15 gene and serum interleukin-15 levels on coronary heart disease. Cytokine 49: 58-63.
11. Pistilli EE, Devaney JM, Gordish-Dressman H, Bradbury MK, Seip RL, et al. (2008) Interleukin-15 and interleukin-15R alpha SNPs and associations with muscle, bone, and predictors of the metabolic syndrome. Cytokine 43: 45-53.
12. Van Gaal LF, Mertens IL, De Block CE (2006) Mechanisms linking obesity with cardiovascular disease. Nature 444: 875-880. (Pubitemid 46028447)
13. Fox CS, Massaro JM, Hoffmann U, Pou KM, Maurovich-Horvat P, et al. (2007) Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study. Circulation 116: 39-48. (Pubitemid 47016245)
14. Despres JP (2012) Body fat distribution and risk of cardiovascular disease: an update. Circulation 126: 1301-1313.
15. Mazurek T, Zhang L, Zalewski A, Mannion JD, Diehl JT, et al. (2003) Human epicardial adipose tissue is a source of inflammatory mediators. Circulation 108: 2460-2466. (Pubitemid 37444406)
16. Malavazos AE, Ermetici F, Coman C, Corsi MM, Morricone L, et al. (2007) Influence of epicardial adipose tissue and adipocytokine levels on cardiac abnormalities in visceral obesity. Int J Cardiol 121: 132-134. (Pubitemid 47285372)
17. Djaberi R, Schuijf JD, van Werkhoven JM, Nucifora G, Jukema JW, et al. (2008) Relation of epicardial adipose tissue to coronary atherosclerosis. Am J Cardiol 102: 1602-1607.
18. Malavazos AE, Corsi MM, Ermetici F, Coman C, Sardanelli F, et al. (2007) Proinflammatory cytokines and cardiac abnormalities in uncomplicated obesity: relationship with abdominal fat deposition. Nutr Metab Cardiovasc Dis 17: 294-302. (Pubitemid 46551684)
19. Dozio E, Dogliotti G, Malavazos AE, Bandera F, Cassetti G, et al. (2012) IL-18 level in patients undergoing coronary artery bypass grafting surgery or valve replacement: which link with epicardial fat depot? Int J Immunopathol Pharmacol 25: 1011-1020.
20. Iacobellis G, Assael F, Ribaudo MC, Zappaterreno A, Alessi G, et al. (2003) Epicardial fat from echocardiography: a new method for visceral adipose tissue prediction. Obes Res 11: 304-310. (Pubitemid 41127400)
21. Schejbal V (1989) Epicardial fatty tissue of the right ventricle-morphology, morphometry and functional significance. Pneumologie 43: 490-499.
22. Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, et al. (2009) Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 120: 1640-1645.
23. Qiao Q, Nyamdorj R (2010) The optimal cutoff values and their performance of waist circumference and waist-to-hip ratio for diagnosing type II diabetes. Eur J Clin Nutr 64: 23-29.
24. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, et al. (2003) Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112: 1796-1808. (Pubitemid 38063703)
25. Ikeoka D, Mader JK, Pieber TR (2010) Adipose tissue, inflammation and cardiovascular disease. Rev Assoc Med Bras 56: 116-121.
26. Quinn LS, Strait-Bodey L, Anderson BG, Argiles JM, Havel PJ (2005) Interleukin-15 stimulates adiponectin secretion by 3T3-L1 adipocytes: evidence for a skeletal muscle-to-fat signaling pathway. Cell Biol Int 29: 449-457. (Pubitemid 41073643)
27. Iacobellis G, Lonn E, Lamy A, Singh N, Sharma AM (2011) Epicardial fat thickness and coronary artery disease correlate independently of obesity. Int J Cardiol 146: 452-454.
28. Sacks HS, Fain JN, Cheema P, Bahouth SW, Garrett E, et al. (2011) Depot-specific overexpression of proinflammatory, redox, endothelial cell, and angiogenic genes in epicardial fat adjacent to severe stable coronary atherosclerosis. Metab Syndr Relat Disord 9: 433-439.
29. Bergamaschi C, Bear J, Rosati M, Beach RK, Alicea C, et al. (2012) Circulating IL-15 exists as heterodimeric complex with soluble IL-15Ralpha in human and mouse serum. Blood 120: e1-8.
30. Neely GG, Epelman S, Ma LL, Colarusso P, Howlett CJ, et al. (2004) Monocyte surface-bound IL-15 can function as an activating receptor and participate in reverse signaling. J Immunol 172: 4225-4234. (Pubitemid 38375235)
31. Budagian V, Bulanova E, Paus R, Bulfone-Paus S (2006) IL-15/IL-15 receptor biology: a guided tour through an expanding universe. Cytokine Growth Factor Rev 17: 259-280. (Pubitemid 44038618)
32. Mariner JM, Lantz V, Waldmann TA, Azimi N (2001) Human T cell lymphotropic virus type I Tax activates IL-15R alpha gene expression through an NF-kappa B site. J Immunol 166: 2602-2609. (Pubitemid 32173498)