Methadone overdose and cardiac arrhythmia potential: Findings from a review of the evidence for an american pain society and college on problems of drug dependence clinical practice guideline

Journal of Pain

Volumn 15, Issue 4, 2014, Pages 338-365

  Chou, Roger ^a,b   Weimer, Melissa B ^a   Dana, Tracy ^b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

evidence based medicine; harms; Methadone; systematic review

Indexed keywords

BENZODIAZEPINE; ILLICIT DRUG; METHADONE; OPIATE;

ADVERSE OUTCOME; ARTICLE; CANCER PAIN; CHRONIC PAIN; CLINICAL PRACTICE; DRUG DEPENDENCE; DRUG DEPENDENCE TREATMENT; DRUG OVERDOSE; DRUG SAFETY; ECG ABNORMALITY; ELECTROCARDIOGRAPHY MONITORING; EVIDENCE BASED MEDICINE; FOLLOW UP; HARM REDUCTION; HEART ARRHYTHMIA; HUMAN; MEDICAL SOCIETY; METHADONE TREATMENT; MORTALITY; OPIATE ADDICTION; PRACTICE GUIDELINE; QT PROLONGATION; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK FACTOR; RISK MANAGEMENT; SUDDEN DEATH; SYSTEMATIC REVIEW; TORSADE DES POINTES; TREATMENT OUTCOME; UNITED STATES; CHEMICALLY INDUCED; COMPLICATION; OPIOID-RELATED DISORDERS;

ARRHYTHMIAS, CARDIAC; CHRONIC PAIN; DRUG OVERDOSE; HUMANS; METHADONE; OPIOID-RELATED DISORDERS; PRACTICE GUIDELINES AS TOPIC;

EID: 84897386210     PISSN: 15265900     EISSN: 15288447     Source Type: Journal    
DOI: 10.1016/j.jpain.2014.01.495     Document Type: Article

References (111)

1. K. Anchersen, T. Clausen, M. Gossop, V. Hansteen, and H. Waal Prevalence and clinical relevance of corrected QT interval prolongation during methadone and buprenorphine treatment: A mortality assessment study Addiction 104 2009 993 999
2. R. Anderson, J.H. Saiers, S. Abram, and C. Schlicht Accuracy in equianalgesic dosing: Conversion dilemmas J Pain Symptom Manage 21 2001 397 406
3. P. Athanasos, A.L. Farquharson, P. Compton, P. Psaltis, and J. Hay Electrocardiogram characteristics of methadone and buprenorphine maintained subjects J Addict Dis 27 2008 31 35
4. M.F. Ballesteros, D.S. Budnitz, C.P. Sanford, J. Gilchrist, G.A. Agyekum, and J. Butts Increase in deaths due to methadone in North Carolina JAMA 290 2003 40
5. D.H. Barrett, A.J. Luk, R.G. Parrish, and T.S. Jones An investigation of medical examiner cases in which methadone was detected, Harris County, Texas, 1987-1992 J Forensic Sci 41 1996 442 448
6. E. Bruera, J.L. Palmer, S. Bosnjak, M.A. Rico, J. Moyano, C. Sweeney, F. Strasser, J. Willey, M. Bertolino, C. Mathias, O. Spruyt, and M.J. Fisch Methadone versus morphine as a first-line strong opioid for cancer pain: a randomized, double-blind study J Clin Oncol 22 2004 185 192
7. W.K. Bryant, S. Galea, M. Tracy, T. Markham Piper, K.J. Tardiff, and D. Vlahov Overdose deaths attributed to methadone and heroin in New York City, 1990-1998 Addiction 99 2004 846 854
8. M.C.A. Buster, G.H.A. van Brussel, and W. van den Brink An increase in overdose mortality during the first 2 weeks after entering or re-entering methadone treatment in Amsterdam Addiction 97 2002 993 1001
9. J.R. Caplehorn, M.S. Dalton, F. Haldar, A.M. Petrenas, and J.G. Nisbet Methadone maintenance and addicts' risk of fatal heroin overdose Subst Use Misuse 31 1996 177 196
10. Centers for Disease Control and Prevention Vital signs: risk for overdose from methadone used for pain relief - United States, 1999-2010 MMWR Morb Mortal Wkly Rep 61 2012 493 497
11. G.M. Chan, M. Stajic, E.K. Marker, R.S. Hoffman, and L.S. Nelson Testing positive for methadone and either a tricyclic antidepressant or a benzodiazepine is associated with an accidental overdose death: Analysis of medical examiner data Acad Emerg Med 13 2006 543 547
12. K.C. Chang, C.L. Huang, H.Y. Liang, S.S. Chang, Y.C. Wang, W.M. Liang, H.Y. Lane, C.H. Chen, and S.K. Stephen Huang Gender-specific differences in susceptibility to low-dose methadone-associated QTc prolongation in patients with heroin dependence J Cardiovasc Electrophysiol 23 2012 527 533
13. R. Chou Comparative efficacy and safety of long-acting oral opioids for chronic non-cancer pain: A systematic review J Pain Symptom Manage 26 2004 1026
14. Chou R, Weimer M, Dana T, Walker M, Mitchell JP: Systematic Evidence Review on Methadone Harms and Comparative Harms. Glenview, IL, American Pain Society, Available at, http://www.americanpainsociety.org/uploads/ files/FINAL-Systematic-Evidence-Review-on-Methadone-Harms.pdf. Accessed February 28, 2014
15. S.S. Chugh, C. Socoteanu, K. Reinier, J. Waltz, J. Jui, and K. Gunson A community-based evaluation of sudden death associated with therapeutic levels of methadone Am J Med 121 2008 66 71
16. Centers for Disease Control and Prevention Community-based opioid overdose prevention programs providing naloxone - United States, 2010 MMWR Morb Mortal Wkly Rep 61 2012 101 105
17. M. Connock, A. Juarez-Garcia, S. Jowett, E. Frew, Z. Liu, R.J. Taylor, A. Fry-Smith, E. Day, N. Lintzeris, T. Roberts, A. Burls, and R.S. Taylor Methadone and buprenorphine for the management of opioid dependence: A systematic review and economic evaluation Health Technol Assess 11 2007 1 171 iii-iv
18. R. Cornish, J. Macleod, J. Strang, P. Vickerman, and M. Hickman Risk of death during and after opiate substitution treatment in primary care: Prospective observational study in UK General Practice Research Database BMJ 341 2010 1 8
19. G. Cousins, C. Teljeur, N. Motterlini, C. McCowan, B.D. Dimitrov, and T. Fahey Risk of drug-related mortality during periods of transition in methadone maintenance treatment: A cohort study J Subst Abuse Treat 41 2011 252 260
20. R.A. Cruciani, R. Sekine, P. Homel, D. Lussier, Y. Yap, Y. Suzuki, P. Schweitzer, S.R. Yancovitz, J.A. Lapin, L. Shaiova, R.G. Sheu, and R.K. Portenoy Measurement of QTc in patients receiving chronic methadone therapy J Pain Symptom Manage 29 2005 385 391
21. Dolophine® hydrochloride tablets (methadone hydrochloride tablets USP) prescribing information Nov 2006. Available at: http://www.accessdata.fda. gov/drugsatfda-docs/label/2006/006134s028lbl.pdf. Accessed January 14, 2014
22. S.H. Downs, and N. Black The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions J Epidemiol Community Health 52 1998 377 384
23. B.J. Drew, R.M. Califf, M. Funk, E.S. Kaufman, M.W. Krucoff, M.M. Laks, P.W. Macfarlane, C. Sommargren, S. Swiryn, G.F. Van Hare, and American Heart Association; Councils on Cardiovascular Nursing, Clinical Cardiology, and Cardiovascular Disease in the Young Practice Standards for Electrocardiographic Monitoring in Hospital Settings: An American Heart Association Scientific Statement From the Councils on Cardiovascular Nursing, Clinical Cardiology, and Cardiovascular Disease in the Young: Endorsed by the International Society of Computerized Electrocardiology and the American Association of Critical-Care Nurses Circulation 110 2004 2721 2746
24. G.B. Ehret, C. Voide, M. Gex-Fabry, J. Chabert, D. Shah, B. Broers, V. Piguet, T. Musset, J.-M. Gaspoz, A. Perrier, P. Dayer, and J.A. Desmeules Drug-induced long QT syndrome in injection drug users receiving methadone: High frequency in hospitalized patients and risk factors Arch Intern Med 166 2006 1280 1287
25. E. Ernst, A. Bartu, A. Popescu, K.F. Ileutt, R. Hansson, and N. Plumley Methadone-related deaths in Western Australia 1993-99 Aust N Z J Public Health 26 2002 364 370
26. J.L. Esses, J. Rosman, L.T. Do, P. Schweitzer, and S. Hanon Successful transition to buprenorphine in a patient with methadone-induced torsades de pointes J Interv Card Electrophysiol 23 2008 117 119
27. S. Fanoe, C. Hvidt, P. Ege, and G.B. Jensen Syncope and QT prolongation among patients treated with methadone for heroin dependence in the city of Copenhagen Heart 93 2007 1051 1055
28. A. Fareed, S. Vayalapalli, J. Byrd-Sellers, J. Casarella, K. Drexler, R. Amar, J. Smith-Cox, and T.S. Lutchman Onsite QTc interval screening for patients in methadone maintenance treatment J Addict Dis 29 2010 15 22
29. A. Fareed, S. Vayalapalli, K. Scheinberg, R. Gale, J. Casarella, and K. Drexler QTc interval prolongation for patients in methadone maintenance treatment: A five years follow-up study Am J Drug Alcohol Abuse 39 2013 235 240
30. Fingerhut LA: Increases in poisoning and methadone-related deaths: United States, 1999-2005. Available at: http://www.cdc.gov/nchs/data/hestat/poisoning/ poisoning.htm. Accessed January 14, 2014
31. F. Fonseca, J. Marti-Almor, A. Pastro, M. Cladellas, M. Farré, R. de la Torre, and M. Torrens Prevalence of long QTc interval in methadone maintenance patients Drug Alcohol Depend 99 2009 327 332
32. A. Gagajewski, and F.S. Apple Methadone-related deaths in Hennepin County, Minnesota: 1992-2002 J Forensic Sci 48 2003 668 671
33. F.R. Gearing, and M.D. Schweitzer An epidemiologic evaluation of long-term methadone maintenance treatment for heroin addiction Am J Epidemiol 100 1974 101 112
34. General Accountability Office: Methadone-associated overdose deaths: Factors contributing to increased deaths and efforts to prevent them. Available at: http://www.gao.gov/products/GAO-09-341. Accessed January 14, 2014
35. GRADE Working Group Grading quality of evidence and strength of recommendations BMJ 328 2004 1490 1494
36. L. Gronbladh, L.S. Ohlund, and L.M. Gunne Mortality in heroin addiction: Impact of methadone treatment Acta Psychiatr Scand 82 1990 223 227
37. L.-M. Gunne, and L. Grönbladh The Swedish methadone maintenance program: A controlled study Drug Alcohol Depend 7 1981 249 256
38. G. Guyatt, D. Gutterman, M.H. Baumann, D. Addrizzo-Harris, E.M. Hylek, B. Phillips, G. Raskob, S.Z. Lewis, and H. Schunemann Grading strength of recommendations and quality of evidence in clinical guidelines: Report from an American College of Chest Physicians Task Force Chest 129 2006 174 181
39. A.J. Hall, J.E. Logan, R.L. Toblin, J.A. Kaplan, J.C. Kraner, D. Bixler, A.E. Crosby, and L.J. Paulozzi Patterns of abuse among unintentional pharmaceutical overdose fatalities JAMA 300 2008 2613 2620
40. S. Hanon, R.M. Seewald, F. Yang, P. Schweitzer, and J. Rosman Ventricular arrhythmias in patients treated with methadone for opioid dependence J Interv Card Electrophysiol 28 2010 19 22
41. R.P. Harris, M. Helfand, S.H. Woolf, K.N. Lohr, C.D. Mulrow, S.M. Teutsch, D. Atkins, Methods Work Group, and Third US Preventive Services Task Force Current methods of the U.S. Preventive Services Task Force: A review of the process Am J Prev Med 20 2001 21 35
42. D.M. Hartung, L. Middleton, D.G. Haxby, M. Koder, K.L. Ketchum, and R. Chou Rates of adverse events of long-acting opioids in a state Medicaid program [Erratum appears in Ann Pharmacother, 2007 Sep;41(9):1552] Ann Pharmacother 41 2007 921 928
43. B. Huh, and C.H. Park Retrospective analysis of low-dose methadone and QTc prolongation in chronic pain patients Korean J Anesthesiol 58 2010 338 343
44. C.E. Inturrisi Clinical pharmacology of opioids for pain Clin J Pain 18 2002 S3 S13
45. R.E. Johnson, M.A. Chutuape, E.C. Strain, S.L. Walsh, M.L. Stitzer, and G.E. Bigelow A comparison of levomethadyl acetate, buprenorphine, and methadone for opioid dependence N Engl J Med 343 2000 1290 1297
46. P. Juni, F. Holenstein, J. Sterne, C. Bartlett, and M. Egger Direction and impact of language bias in meta-analyses of controlled trials: empirical study Int J Epidemiol 31 2002 115 123
47. D. Justo, A. Gal-Oz, Y. Paran, Y. Goldin, and D. Zeltser Methadone-associated torsades de pointes (polymorphic ventricular tachycardia) in opioid-dependent patients Addiction 101 2006 1333 1338
48. D.F. Katz, J. Sun, V. Khatri, D. Kao, B. Bucher-Bartelson, C. Traut, J. Lundin-Martinez, M. Goodman, P.S. Mehler, and M.J. Krantz QTc interval screening in an opioid treatment program Am J Cardiol 112 2013 1013 1018
49. T.W. Kinlock, M.S. Gordon, R.P. Schwartz, K. O'Grady, T.T. Fitzgerald, and M. Wilson A randomized clinical trial of methadone maintenance for prisoners: Results at 1-month post-release Drug Alcohol Depend 91 2007 220 227
50. C.A. Kornick, M.J. Kilborn, J. Santiago-Palma, G. Schulman, H.T. Thaler, D.L. Keefe, A.N. Katchman, J.C. Pezzullo, S.N. Ebert, R.L. Woosley, R. Payne, and P.L. Manfredi QTc interval prolongation associated with intravenous methadone Pain 105 2003 499 506
51. M.J. Krantz Heterogeneous impact of methadone on the QTc interval: What are the practical implications? J Addict Dis 27 2008 5 9
52. M.J. Krantz, J.A. Garcia, and P.S. Mehler Effects of buprenorphine on cardiac repolarization in a patient with methadone-related torsade de pointes Pharmacotherapy 25 2005 611 614
53. M.J. Krantz, I.B. Kutinsky, A.D. Robertson, and P.S. Mehler Dose-related effects of methadone on QT prolongation in a series of patients with torsade de pointes Pharmacotherapy 23 2003 802 805
54. M.J. Krantz, L. Lewkowiez, H. Hays, M.A. Woodroffe, A.D. Robertson, and P.S. Mehler Torsade de pointes associated with very-high-dose methadone Ann Intern Med 137 2002 501 504
55. M.J. Krantz, C.M. Lowery, B.A. Martell, M.N. Gourevitch, and J.H. Arnsten Effects of methadone on QT-interval dispersion Pharmacotherapy 25 2005 1523 1529
56. M.J. Krantz, J. Martin, B. Stimmel, D. Mehta, and M.C.P. Haigney QTc interval screening in methadone treatment Ann Intern Med 150 2009 387 395
57. E.E. Krebs, W.C. Becker, J. Zerzan, M.J. Bair, K. McCoy, and S. Hui Comparative mortality among Department of Veterans Affairs patients prescribed methadone or long-acting morphine for chronic pain Pain 152 2011 1789 1795
58. M. Lindquist, and I.R. Edwards Risks of non-sedating antihistamines Lancet 349 1997 1322
59. J. Lipski, B. Stimmel, and E. Donoso The effect of heroin and multiple drug abuse on the electrocardiogram Am Heart J 86 1973 663 668
60. M.E. Lynch A review of the use of methadone for the treatment of chronic noncancer pain Pain Res Manag 10 2005 133 144
61. I. Maremmani, M. Pacini, C. Cesaroni, M. Lovrecic, G. Perugi, and A. Tagliamonte QTc interval prolongation in patients on long-term methadone maintenance therapy Eur Addict Res 11 2005 44 49
62. B.A. Martell, J.H. Arnsten, M.J. Krantz, and M.N. Gourevitch Impact of methadone treatment on cardiac repolarization and conduction in opioid users Am J Cardiol 95 2005 915 918
63. J.A. Martin, A. Campbell, T. Killip, M. Kotz, M.J. Krantz, M.J. Kreek, B.A. McCarroll, D. Mehta, J. Payte, B. Stimmel, T. Taylor, and B.B. Wilford QT interval screening in methadone maintenance treatment: Report of a SAMHSA expert panel J Addict Dis 30 2011 283 306
64. R.P. Mattick, R. Ali, J.M. White, S. O'Brien, S. Wolk, and C. Danz Buprenorphine versus methadone maintenance therapy: A randomized double-blind trial with 405 opioid-dependent patients Addiction 98 2003 441 452
65. R.P. Mattick, C. Breen, J. Kimber, M. Davoli, R.P. Mattick, C. Breen, J. Kimber, and M. Davoli Methadone maintenance therapy versus no opioid replacement therapy for opioid dependence Cochrane Database Syst Rev 2009 CD002209
66. S. Mayet, M. Gossop, N. Lintzeris, V. Markides, and J. Strang Methadone maintenance, QTc and torsade de pointes: Who needs an electrocardiogram and what is the prevalence of QTc prolongation? Drug Alcohol Rev 30 2011 388 396
67. E.F. McCance-Katz (R)-Methadone versus racemic methadone: What is best for patient care? Addiction 106 2011 687 688
68. C. McCowan, B. Kidd, and T. Fahey Factors associated with mortality in Scottish patients receiving methadone in primary care: Retrospective cohort study BMJ 338 2009 b2225
69. S. Mercadante, A. Casuccio, A. Agnello, R. Serretta, L. Calderone, and L. Barresi Morphine versus methadone in the pain treatment of advanced-cancer patients followed up at home J Clin Oncol 16 1998 3656 3661
70. S. Mercadante, G. Porzio, P. Ferrera, F. Fulfaro, F. Aielli, L. Verna, P. Villari, C. Ficorella, V. Gebbia, S. Riina, A. Casuccio, and S. Mangione Sustained-release oral morphine versus transdermal fentanyl and oral methadone in cancer pain management Eur J Pain 12 2008 1040 1046
71. M. Michel, J. Trafton, S. Martins, D. Wang, S. Tu, N. Johnson, and M.K. Goldstein Improving patient safety using ATHENA-decision support system technology: The opioid therapy for chronic pain experience K. Henriksen, J.B. Battles, M.A. Keyes, M.L. Grady, Advances in Patient Safety: New Directions and Alternative Approaches (Vol. 4: Technology and Medication Safety) 2008 Agency for Healthcare Research and Quality Rockville, MD
72. National Institutes of Health NIH consensus panel recommends expanding access to and improving methadone treatment programs for heroin addiction Eur Addict Res 5 1999 50 51
73. J. Neale Methadone, methadone treatment and non-fatal overdose Drug Alcohol Depend 58 2000 117 124
74. A.M. Neumann, R.D. Blondell, U. Jaanimagi, A.K. Giambrone, G.G. Homish, J.R. Lozano, U. Kowalik, and M. Azadfard A preliminary study comparing methadone and buprenorphine in patients with chronic pain and coexistent opioid addiction J Addict Dis 32 2013 68 78
75. R.G. Newman Attributing fatal cardiac effects to methadone: What's the evidence? J Addict Dis 27 2008 1 4
76. R.G. Newman, and W.B. Whitehill Double-blind comparison of methadone and placebo maintenance treatments of narcotic addicts in Hong Kong Lancet 314 1979 485 488
77. D.K. Owens AHRQ Series Paper 5: Grading the strength of a body of evidence when comparing medical interventions - Agency for Healthcare Research and Quality and the Effective Health-Care Program J Clin Epidemiol 63 2010 513 523
78. P.P. Pani, E. Trogu, I. Maremmani, and M. Pacini QTc interval screening for cardiac risk in methadone treatment of opioid dependence Cochrane Database Syst Rev 6 2013 CD008939
79. L.J. Paulozzi Opioid analgesic involvement in drug abuse deaths in American metropolitan areas Am J Public Health 96 2006 1755 1757
80. L.J. Paulozzi, D.S. Budnitz, and Y. Xi Increasing deaths from opioid analgesics in the United States Pharmacoepidemiol Drug Saf 15 2006 618 627
81. L.J. Paulozzi, and G.W. Ryan Opioid analgesics and rates of fatal drug poisoning in the United States Am J Prev Med 31 2006 506 511
82. E.C. Pearson, and R.L. Woosley QT prolongation and torsades de pointes among methadone users: Reports to the FDA spontaneous reporting system Pharmacoepidemiol Drug Saf 14 2005 747 753
83. E. Peles, G. Bodner, M.J. Kreek, V. Rados, and M. Adelson Corrected-QT intervals as related to methadone dose and serum level in methadone maintenance treatment (MMT) patients: A cross-sectional study Addiction 102 2007 289 300
84. B. Pham, T.P. Klassen, M.L. Lawson, and D. Moher Language of publication restrictions in systematic reviews gave different results depending on whether the intervention was conventional or complementary J Clin Epidemiol 58 2005 769 776
85. S. Reddy, M.J. Fisch, and E. Bruera Oral methadone for cancer pain: no indication of Q-T interval prolongation or torsades de pointes J Pain Symptom Manage 28 2004 301 303
86. S. Reddy, D. Hui, B. El Osta, M. de la Cruz, P. Walker, J. Palmer, and E. Bruera The effect of oral methadone on the QTc interval in advanced cancer patients: A prospective pilot study J Palliat Med 13 2010 33 38
87. C. Ripamonti, F. De Conno, L. Groff, M. Belzile, J. Pereira, J. Hanson, and E. Bruera Equianalgesic dose/ratio between methadone and other opioid agonists in cancer pain: Comparison of two clinical experiences Ann Oncol 9 1998 79 83
88. C. Ripamonti, L. Groff, C. Brunelli, D. Polastri, A. Stavrakis, and F. De Conno Switching from morphine to oral methadone in treating cancer pain: what is the equianalgesic dose ratio? J Clin Oncol 16 1998 3216 3221
89. Rosemont Pharmaceuticals Limited: Methadone hydrochloride DTF 1mg/1ml oral solution. Available at: http://xpil.medicines.org.uk/ViewPil.aspx?DocID= 22767. Accessed January 14, 2014
90. A.K. Roy, C. McCarthy, G. Kiernan, C. McGorrian, E. Keenan, N.G. Mahon, and B. Sweeney Increased incidence of QT interval prolongation in a population receiving lower doses of methadone maintenance therapy Addiction 107 2012 1132 1139
91. J. Schmittner, J.R. Schroeder, D.H. Epstein, M.J. Krantz, N.C. Eid, and K.L. Preston Electrocardiographic effects of lofexidine and methadone coadministration: secondary findings from a safety study Pharmacotherapy 29 2009 495 502
92. A. Seymour, M. Black, J. Jay, G. Cooper, C. Weir, and J. Oliver The role of methadone in drug-related deaths in the west of Scotland Addiction 98 2003 995 1002
93. N. Shah, S.L. Lathrop, and M.G. Landen Unintentional methadone-related overdose death in New Mexico (USA) and implications for surveillance, 1998-2002 Addiction 100 2005 176 188
94. L. Shaiova, A. Berger, C.D. Blinderman, E. Bruera, M.P. Davis, S. Derby, C. Inturrisi, J. Kalman, D. Mehta, M. Pappagallo, and E. Perlov Consensus guideline on parenteral methadone use in pain and palliative care Palliat Support Care 6 2008 165 176
95. B.J. Shea, C. Hamel, G.A. Wells, L.M. Bouter, E. Kristjansson, J. Grimshaw, D.A. Henry, and M. Boers AMSTAR is a reliable and valid measurement tool to assess the methodological quality of systematic reviews J Clin Epidemiol 62 2009 1013 1020
96. M. Stallvik, B. Nordstrand, O. Kristensen, J. Bathen, E. Skogvoll, and O. Spigset Corrected QT interval during treatment with methadone and buprenorphine - Relation to doses and serum concentrations Drug Alcohol Depend 129 2013 88 93
97. M.M. Straus, U.E. Ghitza, and B. Tai Preventing deaths from rising opioid overdose in the US - The promise of naloxone antidote in community-based naloxone take-home programs Subst Abuse Rehabil 4 2013 65
98. S. Sunjic, and D. Zador Methadone-related deaths in New South Wales Med J Aust 166 1997 54 55
99. U.S. Department of Justice DEA: Automation of reports and consolidation order's system (ARCOS): Retail Drug Summary Reports, 1998-2002. Available at: http://www.deadiversion.usdoj.gov/arcos/retail-drug-summary/index.html. Accessed November 8, 2009
100. E.J.C. Van Ameijden, M.W. Langendam, and R.A. Coutinho Dose-effect relationship between overdose mortality and prescribed methadone dosage in low-threshold maintenance programs Addict Behav 24 1999 559 563
101. M. van Tulder, A. Furlan, C. Bombardier, L. Bouter, and Editorial Board of the Cochrane Collaboration Back Review G Updated method guidelines for systematic reviews in the Cochrane Collaboration Back Review Group Spine 28 2003 1290 1299
102. V. Ventafridda, C. Ripamonti, M. Bianchi, A. Sbanotto, and E. De Conno A randomized study on oral administration of morphine and methadone in the treatment of cancer pain J Pain Symptom Manage 1 1986 203 207
103. W.V. Vieweg, M. Hasnain, R.H. Howland, T. Clausen, J.N. Koneru, C. Kogut, E.L. Crouse, J.C. Hancox, A. Fernandez, and A.K. Pandurangi Methadone, QTc interval prolongation and torsade de pointes: Case reports offer the best understanding of this problem Ther Adv Psychopharmacol 3 2013 219 232
104. M. Ward, and J. Barry Opiate-related deaths in Dublin Ir J Med Sci 170 2001 35 37
105. E.F. Wedam, G.E. Bigelow, R.E. Johnson, P.A. Nuzzo, and M.C.P. Haigney QT-interval effects of methadone, levomethadyl, and buprenorphine in a randomized trial Arch Intern Med 167 2007 2469 2475
106. M.B. Weimer, P.T. Korthuis, G.S. Behonick, and M.J. Wunsch The source of methadone in overdose deaths in Western Virginia in 2004 J Addict Med 5 2011 188 202
107. P.A. Williamson, K.J. Foreman, J.M. White, and G. Anderson Methadone-related overdose deaths in South Australia, 1984-1994. How safe is methadone prescribing? Med J Aust 166 1997 302 305
108. D.K. Wysowski, A. Corken, H. Gallo-Torres, L. Talarico, and E.M. Rodriguez Postmarketing reports of QT prolongation and ventricular arrhythmia in association with cisapride and Food and Drug Administration regulatory actions Am J Gastroenterol 96 2001 1698 1703
109. S.R. Yancovitz, D.C. Des Jarlais, N.P. Peyser, E. Drew, P. Friedmann, H.L. Trigg, and J.W. Robinson A randomized trial of an interim methadone maintenance clinic Am J Public Health 81 1991 1185 1191
110. D. Zador, and S. Sunjic Deaths in methadone maintenance treatment in New South Wales, Australia 1990-1995 Addiction 95 2000 77 84
111. D.A. Zador, and S.D. Sunjic Methadone-related deaths and mortality rate during induction into methadone maintenance, New South Wales, 1996 Drug Alcohol Rev 21 2002 131 136