(R)-methadone versus racemic methadone: What is best for patient care?

Addiction

Volumn 106, Issue 4, 2011, Pages 687-688

  Mccance Katz, Elinore F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METHADONE; NARCOTIC AGENT;

CHEMICALLY INDUCED DISORDER; EDITORIAL; HEART ARRHYTHMIA; HUMAN; OPIATE ADDICTION;

ARRHYTHMIAS, CARDIAC; HUMANS; METHADONE; NARCOTICS; OPIOID-RELATED DISORDERS;

EID: 79952306253     PISSN: 09652140     EISSN: 13600443     Source Type: Journal    
DOI: 10.1111/j.1360-0443.2011.03374.x     Document Type: Editorial

References (11)

1. Dole V. P., Nyswander M. A medical treatment for diacetylmorphine (heroin) addiction: a clinical trial with methadone hydrochloride. JAMA 1965; 193: 646-50.
2. Taylor W. F., Finkel A. G., Robertson K. R., Anderson A. C., Toomey T. C., Abashian S.A. etal. Methadone in the treatment of chronic, nonmalignant pain: a 2-year follow-up. Pain Med 2000; 1: 254-9.
3. Krantz M. J., Martin J., Stimmel B., Mehta D., Haigney M. C. P. QTc interval screening in methadone treatment. Ann Int Med 2009; 150: 387-95.
4. Zunkler B. J., Wos-Maganga M. Comparison of the effects of methadone and heroin on human ether-á-go-go-related gene channels. Cardiovasc Toxicol 2010; 10: 161-5.
5. Lin C., Somberg T., Molnar J., Somberg J. The effects of chiral isolates of methadone on the cardiac potassium channel IKr. Cardiology 2009; 113: 59-65.
6. Ansermot N., Albayrak O., Schlapfer J., Crettol S., Croquette-Krokar M., Bourquin M. etal. Substitution of (R, S)-methadone by (R)-methadone: impact on QTc interval. Arch Intern Med 2010; 170: 529-36.
7. Gourevitch M. First, do no harm...reduction? Ann Int Med 2009; 150: 417-18.
8. Wedam E. F., Bigelow G. E., Johnson R. E., Nuzzo P. A., Haigney M. C. QT-interval effects of methadone, levomethadyl, and buprenorphine in a randomized trial. Arch Intern Med 2007; 167: 2469-75.
9. Butrans full prescribing information. Available at: (accessed 18 December 2010).
10. Ling W., Wesson D. R. Naltrexone treatment for addicted healthcare professionals: a collaborative private practice experience. J Clin Psychiatry 1984; 45: 46-8.
11. Coviello D. M., Cornish J. W., Lynch K. G., Alterman A. I., O'Brien C. P. A randomized trial of oral naltrexone for treating opioid-dependent offenders. Am J Addict 2010; 19: 422-3.