A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases

Scientific Reports

Volumn 4, Issue , 2014, Pages

  Rashid, M Harunur ^a,b   Huq, Redwan ^c   Tanner, Mark R ^c   Chhabra, Sandeep ^a   Khoo, Keith K ^a   Estrada, Rosendo ^d   Dhawan, Vikas ^d   Chauhan, Satendra ^d   Pennington, Michael W ^d   Beeton, Christine ^c   Kuyucak, Serdar ^b   Norton, Raymond S ^a  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d Peptides International   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDE FRAGMENT; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL KV1.1; POTASSIUM CHANNEL KV1.3; PROTEIN BINDING; SCORPION VENOM; TX1 TOXIN, HETEROMETRUS SPINNIFER;

AMINO ACID SEQUENCE; ANIMAL; ANTAGONISTS AND INHIBITORS; AUTOIMMUNE DISEASES; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; IC50; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MOLECULAR GENETICS; MOUSE; PROTEIN CONFORMATION; PROTEIN STABILITY;

AMINO ACID SEQUENCE; ANIMALS; AUTOIMMUNE DISEASES; CELL LINE; INHIBITORY CONCENTRATION 50; KV1.1 POTASSIUM CHANNEL; KV1.3 POTASSIUM CHANNEL; LYMPHOCYTE ACTIVATION; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; POTASSIUM CHANNEL BLOCKERS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STABILITY; SCORPION VENOMS;

EID: 84897147621     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep04509     Document Type: Article

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