Selective inhibition of PI3K/Akt/mTOR signaling pathway regulates autophagy of macrophage and vulnerability of atherosclerotic plaque

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Zhai, Chungang ^a   Cheng, Jing ^a   Mujahid, Haroon ^a   Wang, Hefeng ^a   Kong, Jing ^a   Yin, Yue ^a   Li, Jifu ^a   Zhang, Yun ^a   Ji, Xiaoping ^a   Chen, Wenqiang ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOPHAGY PROTEIN 12; AUTOPHAGY PROTEIN 5; BECLIN 1; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MEMBRANE PROTEIN; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN 1 LIGHT CHAIN 3 II; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; CHROMONE DERIVATIVE; CYTOKINE; LIPID; MORPHOLINE DERIVATIVE; RAPAMYCIN; RIBONUCLEOSIDE; TARGET OF RAPAMYCIN KINASE; TRICIRIBINE;

ABDOMINAL AORTA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROTIC PLAQUE; AUTOPHAGY; CELL ULTRASTRUCTURE; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME INHIBITION; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; INTRAVASCULAR ULTRASOUND; NONHUMAN; PERITONEUM MACROPHAGE; PROTEIN EXPRESSION; RABBIT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; ATHEROSCLEROSIS; BLOOD; CELL CULTURE; DRUG EFFECTS; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; PLAQUE, ATHEROSCLEROTIC; SECRETION (PROCESS);

ANIMALS; ATHEROSCLEROSIS; AUTOPHAGY; CELLS, CULTURED; CHROMONES; CYTOKINES; LIPIDS; MACROPHAGES, PERITONEAL; MORPHOLINES; PHOSPHATIDYLINOSITOL 3-KINASES; PLAQUE, ATHEROSCLEROTIC; PROTO-ONCOGENE PROTEINS C-AKT; RABBITS; RIBONUCLEOSIDES; SIGNAL TRANSDUCTION; SIROLIMUS; TOR SERINE-THREONINE KINASES;

EID: 84897146296     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0090563     Document Type: Article

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