The role of hypoxia-inducible factor 1α in allergic rhinitis

American Journal of Rhinology and Allergy

Volumn 28, Issue 2, 2014, Pages

  Mo, Ji Hun ^a   Kim, Ji Hye ^a   Lim, Dae Jun ^b   Kim, Eun Hee ^a  

^a Dankook University College of Medicine   (South Korea)

^b Konkuk University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHOXYESTRADIOL; ALUMINUM HYDROXIDE; ALUMINUM POTASSIUM SULFATE; GAMMA INTERFERON; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN E; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; MESSENGER RNA; OVALBUMIN; VASCULOTROPIN; 2-METHOXYESTRADIOL; ALLERGEN; ESTRADIOL; VASCULOTROPIN A;

ALLERGIC REACTION; ALLERGIC RHINITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EOSINOPHIL; EOSINOPHIL COUNT; EOSINOPHILIA; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; NOSE MUCOSA; PRICK TEST; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPLEEN CELL; TH2 CELL; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; CELL CULTURE; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; INTRANASAL DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; METABOLISM; PATHOLOGY; SPLEEN;

ADMINISTRATION, INTRANASAL; ALLERGENS; ANIMALS; ANTIBODY FORMATION; CELLS, CULTURED; DISEASE MODELS, ANIMAL; EOSINOPHILS; ESTRADIOL; FEMALE; GENE EXPRESSION REGULATION; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOGLOBULIN E; INJECTIONS, INTRAPERITONEAL; INTERLEUKIN-4; INTERLEUKIN-5; MICE; MICE, INBRED BALB C; NASAL MUCOSA; OVALBUMIN; RHINITIS, ALLERGIC; RNA, MESSENGER; SPLEEN; TH2 CELLS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84897139745     PISSN: 19458924     EISSN: 19458932     Source Type: Journal    
DOI: 10.2500/ajra.2014.28.4025     Document Type: Article

References (16)

1. Dehne N, and Brüne B. HIF-1 in the inflammatory microenvironment. Exp Cell Res 315:1791-1797, 2009.
2. Lee SY, Kwon S, Kim KH, et al. Expression of vascular endothelial growth factor and hypoxia-inducible factor in the airway of asthmatic patients. Ann Allergy Asthma Immunol 97:794-799, 2006. (Pubitemid 46032432)
3. Shun CT, Lin SK, Hong CY, et al. Hypoxia induces cysteine-rich 61, vascular endothelial growth factor, and interleukin-8 expressions in human nasal polyp fibroblasts: An implication of neutrophils in the pathogenesis of nasal polyposis. Am J Rhinol Allergy 25:15-18, 2011.
4. Mo JH, Kang EK, Quan SH, et al. Anti-tumor necrosis factor-alpha treatment reduces allergic responses in an allergic rhinitis mouse model. Allergy 66:279-286, 2011.
5. Kuo HP, Lee DF, Xia W, et al. TNFalpha induces HIF-1alpha expression through activation of IKKbeta. Biochem Biophys Res Commun 389:640-644, 2009.
6. Mabjeesh NJ, Escuin D, LaVallee TM, et al. 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Cancer Cell 3:363-375, 2003. (Pubitemid 38340305)
7. Fotsis T, Zhang Y, Pepper MS, et al. The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth. Nature 368:237-239, 1994. (Pubitemid 24108838)
8. Wang GL, and Semenza GL. Purification and characterization of hypoxia-inducible factor 1. J Biol Chem 270:1230-1237, 1995.
9. Lee YC, Kwak YG and Song CH. Contribution of vascular endothelial growth factor to airway hyperresponsiveness and inflammation in a murine model of toluene diisocyanate-induced asthma. J Immunol 168:3595-3600, 2002. (Pubitemid 34250430)
10. Dvorak HF, Detmar M, Claffey KP, et al. Vascular permeability factor/vascular endothelial growth factor: An important mediator of angiogenesis in malignancy and inflammation. Int Arch Allergy Immunol 107:233-235, 1995.
11. Qu-Hong, Nagy JA, Senger DR, et al. Ultrastructural localization of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) to the abluminal plasma membrane and vesiculovacuolar organelles of tumor microvascular endothelium. J Histochem Cytochem 43:381-389, 1995.
12. Park SJ, Lee KS, Kim SR, et al. AMPK activation reduces vascular permeability and airway inflammation by regulating HIF/VEGFA pathway in a murine model of toluene diisocyanate-induced asthma. Inflamm Res 61:1069-1083, 2012.
13. Kim SR, Lee KS, Park HS, et al. HIF-1alpha inhibition ameliorates an allergic airway disease via VEGF suppression in bronchial epithelium. Eur J Immunol 40:2858-2869, 2010.
14. Bousquet J, Jeffery PK, Busse WW, et al. Asthma. From broncho-constriction to airways inflammation and remodeling. Am J Respir Crit Care Med 161:1720-1745, 2000. (Pubitemid 30329053)
15. Dvorak HF, Brown LF, Detmar M, and Dvorak AM. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol 146:1029-1039, 1995.
16. Lee KS, Park SJ, Kim SR, et al. Phosphoinositide 3-kinase-delta inhibitor reduces vascular permeability in a murine model of asthma. J Allergy Clin Immunol 118:403-409, 2006. (Pubitemid 44142718)