Mechanisms of high-dose citalopram-induced death in a rat model

Toxicology

Volumn 302, Issue 2-3, 2012, Pages 248-254

  Beaune, Sébastien ^a,b   Callebert, Jacques ^a,c   Baud, Frédéric J ^a,c,d   Risède, Patricia ^a   Juvin, Philippe ^b,d   Mégarbane, Bruno ^a,c,d  

^a INSERM   (France)

^b HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

^c HÔPITAL LARIBOISIÈRE   (France)

^d UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Citalopram; Cyproheptadine; Fatality; Overdose; Plethysmography; Respiratory effects; Seizure; Serotonin syndrome; Toxicity

Indexed keywords

CITALOPRAM; CYPROHEPTADINE; DIAZEPAM; LACTIC ACID; PROPRANOLOL; SEROTONIN; SEROTONIN UPTAKE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL GAS; ARTICLE; BODY TEMPERATURE; CITALOPRAM INDUCED DEATH; CONTROLLED STUDY; DOSE RESPONSE; DRUG FATALITY; DRUG MEGADOSE; HYPERCAPNIA; HYPOXEMIA; INSPIRATORY CAPACITY; LACTATE BLOOD LEVEL; LD 50; LUNG EDEMA; MALE; NEUROPROTECTION; NONHUMAN; PLETHYSMOGRAPHY; PRIORITY JOURNAL; RAT; SEIZURE; SEROTONIN BLOOD LEVEL; ANIMAL; BLOOD; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; SEROTONIN SYNDROME; SPRAGUE DAWLEY RAT;

RATTUS;

ANIMALS; BODY TEMPERATURE; CITALOPRAM; CYPROHEPTADINE; DIAZEPAM; DOSE-RESPONSE RELATIONSHIP, DRUG; LETHAL DOSE 50; MALE; RATS; RATS, SPRAGUE-DAWLEY; SEIZURES; SEROTONIN; SEROTONIN SYNDROME; SEROTONIN UPTAKE INHIBITORS;

EID: 84897119314     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2012.08.006     Document Type: Article

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