Comparison of citalopram and other selective serotonin reuptake inhibitor ingestions in children

Clinical Toxicology

Volumn 50, Issue 5, 2012, Pages 418-423

  Klein Schwartz, Wendy ^a   Benson, Blaine E ^b   Lee, Samantha C ^a   Litovitz, Toby ^c,d  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^b UNIVERSITY OF NEW MEXICO   (United States)

^c GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

Antidepressants; Pediatric; Poisoning

Indexed keywords

CITALOPRAM; ESCITALOPRAM; FLUOXETINE; FLUVOXAMINE; PAROXETINE; SERTRALINE;

AGITATION; ARTICLE; CHILD; CONTROLLED STUDY; DIARRHEA; DROWSINESS; FEMALE; FEVER; HAZARD; HEART ARRHYTHMIA; HUMAN; HYPERTENSION; HYPERTHERMIA; HYPOTENSION; INGESTION; IRRITABILITY; LETHARGY; MALE; MYDRIASIS; OUTCOME ASSESSMENT; PRESCHOOL CHILD; QT PROLONGATION; RETROSPECTIVE STUDY; SEIZURE; TACHYCARDIA; TREMOR; VOMITING;

AGE FACTORS; CHILD, PRESCHOOL; CITALOPRAM; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROCARDIOGRAPHY; FEMALE; HUMANS; INFANT; MALE; POISON CONTROL CENTERS; PRACTICE GUIDELINES AS TOPIC; RETROSPECTIVE STUDIES; SEIZURES; SEROTONIN UPTAKE INHIBITORS; TRIAGE; UNITED STATES;

EID: 84861036804     PISSN: 15563650     EISSN: 15569519     Source Type: Journal    
DOI: 10.3109/15563650.2012.678497     Document Type: Article

References (27)

1. Barbey JT, Roose SP. SSRI safety in overdose. J Clin Psychiatry 1998; 59:42-48.
2. Waring WS, Gray JA, Graham A. Predictive factors for generalized seizures after deliberate citalopram overdose. Br J Clin Pharmacol 2008; 66:861-865.
3. Personne M, Persson H, Sjoberg E. Citalopram toxicity. Lancet 1997; 350:518-519.
4. Isbister GK, Bowe SJ, Dawson A, Whyte IM. Relative toxicity of selective serotonin reuptake inhibitors (SSRIs) in overdose. J Toxicol Clin Toxicol 2004; 42:277-285.
5. White NC, Litovitz T, Clancy C. Suicidal antidepressant overdoses: A comparative analysis by antidepressant type. J Med Tox 2008; 4:238-250.
6. Hayes BD, Klein-Schwartz W, Clark RF, Muller AA, Miloradovich JE. Comparison of toxicity of acute overdoses with citalopram and escitalopram. J Emerg Med 2010; 39:44-48.
7. Nelson LS, Erdman AR, Booze LL, Cobaugh DJ, Chyka PA. Woolf AD, et al. Selective serotonin reuptake inhibitor poisoning: An evidence-based consensus guideline for out-of-hospital management. Clin Toxicol 2007; 45:315-332.
8. Watson WA, Litovitz TL, Rodgers GC, Klein-Schwartz W, Youniss J, Rose SR, et al. 2002 Annual Report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Amer J Emerg Med 2003; 24:353-421.
9. Catalano G, Catalano MC, Epstein MA, Tsambiras PE. QTc interval prolongation associated with citalopram overdose: A case report and literature review. Clin Neuropharmacol 2001; 24:158-162.
10. Engebretsen KM, Harris CR, Wood JE. Cardiotoxicity and late onset seizures with citalopram overdose. J Emerg Med 2003; 25:163-166.
11. Isbister GK, Friberg LE, Duffull SB. Application of pharmacokinetic- pharmacodynamic modelling in management of QT abnormalities after citalopram overdose. Intensive Care Med 2006; 32: 1060-1065.
12. de Gregorio C, Morabito G, Cerrito M, Dattilo G, Oreto G. Citalopraminduced long QT syndrome and torsade de pointes: Role for concomitant therapy and disease. Int J Cardiol 2011; 148:226-228.
13. Kanjanauthai S, Kanluen T, Chareonthaitawee P. Citalopram induced torsade de pointes, a rare life threatening side effect. Int J Cardiol 2008; 131:e33-e34.
14. Fayssoil A, Issi J, Guerbaa M, Raynaud JC, Heroguelle V. Torsade de pointes induced by citalopram and amiodarone. Ann Cardiol Angeiol (Paris) 2011; 60:165-168.
15. Aströ m-Lilja C, Odeberg JM, Ekman E, H ä gg S. Drug-induced torsades de pointes: A review of the Swedish pharmacovigilance database. Pharmacoepidemiol Drug Saf 2008; 17:587-592.
16. Tarabar AF, Hoffman RS, Nelson L. Citalopram overdose: Late presentation of torsades de pointes (TdP) with cardiac arrest. J Med Toxicol 2008; 4:101-105.
17. Meuleman C, Jourdain P, Bellorini M, Sadeg N, Loiret J, Guillard N, et al. Citalopram and Torsades de Pointes. A case report. Arch Mal Coeur Vaiss 2001; 94:1021-1024.
18. Kelly CA, Dhaun N, Laing WJ, Stra-chan FE, Good AM, Bateman DN, et al. Comparative toxicity of citalopram and the newer antidepressants after overdose. J Toxicol Clin Toxicol 2004; 42:67-71.
19. Kelsey JE, Nemeroff CB. Selective serotonin reuptake inhibitors: Citalopram. In: Sadock BJ, Sadock VA, eds. Kaplan and Sadock ' s comprehensive textbook of psychiatry, 7th edn. Philadelphia: Lippincott Williams & Wilkins; 2000: 2435-2438.
20. Pacher P, Ungvari Z, Nanasi PP, Furst S, Kecskemeti V. Speculations on difference between tricyclic and selective serotonin reuptake inhibitor anti-depressants on their cardiac effects. Is there any? Curr Med Chem 1999; 6:469-480.
21. Hyttel J. Citalopram-pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity. Prog Neuropsychopharmacol Biol Psychiatry 1982; 6:277-295.
22. Witchel HJ, Pabbathi VK, Hofmann G, Paul AA, Hancox JC. Inhibitory actions of the selective serotonin re-uptake inhibitor citalopram on HERG and ventricular L-type calcium currents. FEBS Lett 2002; 512:59-66.
23. Ostrom M, Eriksson A, Thorson J, Spigset O. Fatal overdose with citalopram. Lancet 1996; 348:339-340.
24. Worm K, Dragsholt C, Simonsen K, Kringsholm B. Citalopram concentrations in samples from autopsies and living persons. Int J Legal Med 1998; 111:188-190.
25. Birkett MA, Shinday NM, Kessler EJ, Meyer JS, Ritchie S, Rowlett JK, et al. Acute anxiogenic-like effects of selective serotonin reuptake inhibitors are attenuated by the benzodiazepine diazepam in BALB/c mice. Pharmacol Biochem Behav 2011; 98:544-551.
26. Choi HC, Kim YI, Song HK, Kim JE, Kim DS, Kang TC, et al. Effects of selective serotonin reuptake inhibitors on GABAergic inhibition in the hippocampus of normal and pilocarpine induced epileptic rats. Brain Res 2010; 1357:131-141.
27. Jarmamillo JE, Marchbanks B, Willis B, Forrester MB. Evaluation of completeness of selected poison control center data fields. J Med Syst 2010; 34:499-507.