Lung mechanics and end-expiratory lung volume during hypoxia in rats

Journal of Applied Physiology

Volumn 87, Issue 1, 1999, Pages 15-21

  Bonora, M ^a   Vizek, M ^b  

^a SORBONNE UNIVERSITÉ   (France)

^b CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Atropine; Braking of expiratory airflow; Dynamic lung compliance; End expiratory activity of the diaphragm; Postinspiratory inspiratory activity; Total lung resistance

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREATHING MUSCLE; CONTROLLED STUDY; EXPIRATORY RESERVE VOLUME; HYPOCAPNIA; HYPOXIA; INSPIRATORY CAPACITY; LUNG COMPLIANCE; LUNG MECHANICS; LUNG MINUTE VOLUME; LUNG RESISTANCE; LUNG VENTILATION; LUNG VOLUME; NONHUMAN; PRESSURE VOLUME CURVE; PRIORITY JOURNAL; RAT;

EID: 0032802915     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1999.87.1.15     Document Type: Article

References (36)

1. Barer, G. R., J. Herget, P. J. M. Sloan, and A. J. Suggett. The effect of actute and chronic hypoxia on thoracic gas volume in anesthetized rats. J. Physiol. (Lond.) 277: 177-192, 1978.
2. Bartlett, D., Jr. Effects of hypercapnia and hypoxia on laryngeal resistance to airflow. Respir. Physiol. 37: 297-302, 1979.
3. Bickler, P. E., R. Dueck, R. J. Prutow. Effects of barbiturate anesthesia on functional residual capacity and ribcage/diaphragm contributions to ventilation. Anesthesiology 66: 147-152, 1987.
4. Bonora, M., and M. Boulé. Effects of hypercapnia and hypoxia on inspiratory and expiratory diaphragmatic activity in conscious cats. J. Appl. Physiol. 77: 1644-1652, 1994.
5. Bonora, M., M. Boulé, and H. Gautier. Diaphragmatic and ventilatory responses to alveolar hypoxia and hypercapnia in conscious kittens. J. Appl. Physiol. 72: 1644-1652, 1992.
6. Bonora, M., and M. Vizek. Changes in end-expiratory lung volume and diaphragmatic activity during hypoxia and hypercapnia in cats. J. Appl. Physiol. 79: 1900-1907, 1995.
7. Bonora, M., and M. Vizek. Role of vagal fibers in the hypoxia-induced increases in end-expiratory lung volume and diaphragmatic activity. J. Appl. Physiol. 83: 700-706, 1997.
8. Bouverot, P., and R. S. Fitzgerald. Role of the arterial chemoreceptors in controlling lung volume in the dog. Respir. Physiol. 7: 203-215, 1969.
9. Caldeira, M. P. R., P. H. N. Saldiva, and W. A. Zin. Vagal influences on respiratory mechanics, pressures, and control in rats. Respir. Physiol. 73: 43-54, 1988.
10. Cragg, P., and D. B. Drysdale. Interaction of hypoxia and hypercapnia on ventilation, tidal volume and respiratory frequency in the anesthetized rat. J. Physiol. (Lond.) 341: 477-493, 1983.
11. Crosfill, M. L., and J. G. Widdicombe. Physical characteristics of the chest and lungs and the work of breathing in different mammalian species. J. Physiol. (Lond.) 158: 1-14, 1961.
12. Denjean, A., E. Canet, J. P. Praud, C. Gaultier, and M. Bureau. Hypoxia-induced bronchial responsiveness in awake sheep: role of carotid chemoreceptors. Respir. Physiol. 83: 201-210, 1991.
13. De Troyer, A., J. C. Yernault, and D. Rodenstein. Effects of vagal blockade on lung mechanics in normal man. J. Appl. Physiol. 46: 217-226, 1979.
14. Garfinkel, F., and R. S. Fitzgerald. The effect of hyperoxia, hypoxia and hypercapnia on FRC and occlusion pressure in human subjects. Respir. Physiol. 33: 241-250, 1978.
15. Gautier, H., J. E. Remmers, and D. Bartlett, Jr. Control of the duration of expiration. Respir. Physiol. 18: 205-221, 1973.
16. Goldstein, R. S., N. Zamel, and A. S. Rebuck. Absence of effects of hypoxia on small airway function in humans. J. Appl. Physiol. 47: 251-256, 1979.
17. Green, M., and J. Widdicombe. The effects of ventilation of dogs with different gas mixtures on airway calibre and lung mechanics. J. Physiol. (Lond.) 186: 363-381, 1966.
18. Holtzman, M. J., H. L. Hahn, K. Sasaki, B. E. Skoogh, P. D. Graf, L. M. Fabbri, and J. A. Nadel. Selective effect of general anesthetics on reflex bronchoconstrictor responses in dogs. J. Appl. Physiol. 53: 126-133, 1982.
19. Iscoe, S., and J. T. Fisher. Bronchomotor responses to hypoxia and hypercapnia in decerebrate cats. J. Appl. Physiol. 78: 117-123, 1995.
20. Julia-Serda, G., N. A. Molfino, H. G. Furlott, P. A. McClean, A. S. Rebuck, V. Hoffstein, A. S. Slutsky, N. Zamel, and K. R. Chapman. Tracheobronchial dilation during isocapnic hypoxia in conscious humans. J. Appl. Physiol. 75: 1728-1733, 1993.
21. Lamm, W. J. E., J. R. Hildebrandt, J. Hildebrandt, and Y. L. Lai. End-expiratory volume in the rat: effects of consciousness and body position. J. Appl. Physiol. 53: 1071-1079, 1982.
22. Ludwig, M. S., I. Dreshaj, J. Solway, A. Munoz, and R. H. Ingram, Jr. Partitioning of pulmonary resistance during constriction in the dog: effects of volume history. J. Appl. Physiol. 62: 807-815, 1987.
23. Mead, J., and J. L. Whittenberger. Physical properties of human lungs measured during spontaneous respiration. J. Appl. Physiol. 5: 779-796, 1953.
24. Nadel, J. A., and J. G. Widdicombe. Effects of changes in blood gas tensions and carotid sinus pressure on tracheal volume and total lung resistance to airflow. J. Physiol. (Lond.) 163: 13-33, 1962.
25. 2 tension on flow resistance. J. Appl. Physiol. 19: 745-749, 1964.
26. Palecek, F. Measurement of ventilatory mechanics in the rat. J. Appl. Physiol. 27: 149-156, 1969.
27. Saunders, N. A., M. F. Betts, L. D. Pengelly, and A. S. Rebuck. Changes in lung mechanics induced by acute isocapnic hypoxia. J. Appl. Physiol. 42: 413-419, 1977.
28. Simon, B. A., P. B. Zanaboni, and D. P. Nyhan. Effect of hypoxia on respiratory system impedance in dogs. J. Appl. Physiol. 83: 451-458, 1997.
29. Smith, C. A., D. M. Ainsworth, K. S. Henderson, and J. A. Dempsey. Differential timing of respiratory muscles in response to chemical stimuli in awake dogs. J. Appl. Physiol. 66: 392-399, 1989.
30. Strieder, D. J., R. Laguarda, L. C. Stigol, and M. E. Wohl. Increased recoil during acute hypoxia in dogs. Respir. Physiol. 21: 193-201, 1974.
31. Thomas, T., and J. M. Marshall. Interdependence of respiratory and cardiovascular changes induced by systemic hypoxia in the rat: the roles of adenosine. J. Physiol. (Lond.) 480: 627-636, 1994.
32. Vizek, M., and M. Bonora. Diaphragmatic activity during biphasic ventilatory response to hypoxia in rats. Respir. Physiol. 111: 153-162, 1998.
33. Vizek, M., M. Frydrychova, S. Houstek, and F. Palecek. The role of vagal nerves in changes of functional residual lung capacity during acute hypoxia. Physiol. Bohemoslov. 32: 318-323, 1983.
34. Wetzel, R. C., C. J. Herold, E. A. Zerhouni, and J. L. Robotham. Hypoxic bronchodilation. J. Appl. Physiol. 73: 1202-1206, 1992.
35. Yu, L. K. H., L. Y. Lee, and D. J. Frazier. Effects of bronchoconstriction on breathing during normoxia and hypoxia in anesthetized cats. Respir. Physiol. 57: 31-45, 1984.
36. Zin, W. A., L. D. Pengelly, and J. Milic-Emili. Single-breath method for measurement of respiratory mechanics in anesthetized animals. J. Appl. Physiol. 52: 1266-1271, 1982.