Seroclearance rate of hepatitis B surface antigen in 2,112 patients with chronic hepatitis in Japan during long-term follow-up

Journal of Gastroenterology

Volumn 49, Issue 3, 2014, Pages 538-546

  Kobayashi, Mariko ^a   Hosaka, Tetsuya ^a   Suzuki, Fumitaka ^a   Akuta, Norio ^a   Sezaki, Hitomi ^a   Suzuki, Yoshiyuki ^a   Kawamura, Yusuke ^a   Kobayashi, Masahiro ^a   Saitoh, Satoshi ^a   Arase, Yasuji ^a   Ikeda, Kenji ^a   Miyakawa, Yuzo ^b   Kumada, Hiromitsu ^a  

^a TORANOMON HOSPITAL   (Japan)

^b Miyakawa Memorial Research Foundation   (Japan)

Author keywords

Chronic hepatitis B; Hepatitis B surface antigen; Hepatitis B virus; Seroclearance

Indexed keywords

ADEFOVIR DIPIVOXIL; ASPARTATE AMINOTRANSFERASE; BETA INTERFERON; ENTECAVIR; GAMMA GUANOSINE TRIPHOSPHATE; GUANOSINE TRIPHOSPHATE; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIGEN; LAMIVUDINE; PEGINTERFERON ALPHA; PREDNISOLONE; UNCLASSIFIED DRUG; VIRUS DNA;

ADD ON THERAPY; ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; CHRONIC HEPATITIS; DRUG WITHDRAWAL; FEMALE; FOLLOW UP; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; INFANT; INFECTION RISK; JAPAN; JAPANESE; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; THROMBOCYTE COUNT; TREATMENT DURATION; VERY ELDERLY; WILD TYPE; YOUNG ADULT; BLOOD; ISOLATION AND PURIFICATION; KAPLAN MEIER METHOD; PROPORTIONAL HAZARDS MODEL; RETROSPECTIVE STUDY; SEROLOGY; TIME; VIROLOGY;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CHILD; CHILD, PRESCHOOL; DNA, VIRAL; FEMALE; FOLLOW-UP STUDIES; HEPATITIS B E ANTIGENS; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; INFANT; JAPAN; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; PROPORTIONAL HAZARDS MODELS; RETROSPECTIVE STUDIES; SEROLOGIC TESTS; TIME FACTORS; YOUNG ADULT;

EID: 84897117119     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-013-0821-2     Document Type: Article

References (21)

1. Ganem D, Prince AM. Hepatitis B virus infection - natural history and clinical consequences. N Engl J Med. 2004;350:1118-29. (Pubitemid 38298992)
2. Lee WM. Hepatitis B virus infection. N Engl J Med. 1997;337:1733-45. (Pubitemid 27527771)
3. Chen CJ, Yang HI, Su J, Jen CL, You SL, Lu SN, et al. Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level. JAMA. 2006;295:65-73. (Pubitemid 43042691)
4. Huo TI, Wu JC, Lee PC, Chau GY, Lui WY, Tsay SH, et al. Seroclearance of hepatitis B surface antigen in chronic carriers does not necessarily imply a good prognosis. Hepatology. 1998;28:231-6.
5. Iloeje UH, Yang HI, Su J, Jen CL, You SL, Chen CJ. Predicting cirrhosis risk based on the level of circulating hepatitis B viral load. Gastroenterology. 2006;130:678-86. (Pubitemid 43374518)
6. Arase Y, Ikeda K, Suzuki F, Suzuki Y, Saitoh S, Kobayashi M, et al. Long-term outcome after hepatitis B surface antigen seroclearance in patients with chronic hepatitis B. Am J Med. 2006;119:71.e9-16.
7. Chen YC, Sheen IS, Chu CM, Liaw YF. Prognosis following spontaneous HBsAg seroclearance in chronic hepatitis B patients with or without concurrent infection. Gastroenterology. 2002;123:1084-9.
8. Chu CM, Liaw YF. HBsAg seroclearance in asymptomatic carriers of high endemic areas: appreciably high rates during a long-term follow-up. Hepatology. 2007;45:1187-92.
9. Yuen MF, Wong DK, Fung J, Ip P, But D, Hung I, et al. HBsAg seroclearance in chronic hepatitis B in Asian patients: replicative level and risk of hepatocellular carcinoma. Gastroenterology. 2008;135:1192-9.
10. Suzuki F, Arase Y, Suzuki Y, Akuta N, Sezaki H, Seko Y, et al. Long-term efficacy of interferon therapy in patients with chronic hepatitis B virus infection in Japan. J Gastroenterol. 2012;47:814-22.
11. Kobayashi M, Suzuki F, Akuta N, Hosaka T, Sezaki H, Yatsuji H, et al. Loss of hepatitis B surface antigen from the serum of patients with chronic hepatitis treated with lamivudine. J Med Virol. 2007;79:1472-7. (Pubitemid 47328735)
12. Akuta N, Suzuki F, Suzuki Y, Sezaki H, Hosaka T, Someya T, et al. Favorable efficacy of long-term lamivudine therapy in patients with chronic hepatitis B: an 8-year follow-up study. J Med Virol. 2005;75:491-8. (Pubitemid 40293515)
13. Hosaka T, Suzuki F, Kobayashi M, Seko Y, Kawamura Y, Sezaki H, et al. Clearance of hepatitis B surface antigen during long-term nucleot(s)ide analog treatment in chronic hepatitis B: results from a nine-year longitudinal study. J Gastroenterol. 2012. doi:10.1007/s00535-012-0688-7.
14. Ahn SH, Park YN, Park JY, Chang HY, Lee JM, Shin JE, et al. Long-term clinical and histological outcomes in patients with spontaneous hepatitis B surface antigen seroclearance. J Hepatol. 2005;42:188-94. (Pubitemid 40143464)
15. Kim JH, Lee JH, Park SJ, Bae MH, Kim JH, Kim do Y, et al. Factors associated with natural seroclearance of hepatitis B surface antigen and prognosis after seroclearance: a prospective follow-up study. Hepatogastroenterology. 2008;55:578-81.
16. Liaw YF, Leung N, Kao JH, Piratvisuth T, Gane E, Han KH, et al. Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2008 update. Hepatol Int. 2008;2:263-83.
17. Liu J, Yang HI, Lee MH, Lu SN, Jen CL, Wang LY, et al. Incidence and determinants of spontaneous hepatitis B surface antigen seroclearance: a community-based follow-up study. Gastroenterology. 2010;139:474-82.
18. Kato Y, Nakao K, Hamasaki K, Kato H, Nakata K, Kusumoto Y, et al. Spontaneous loss of hepatitis B surface antigen in chronic carriers, based on a long-term follow-up study in Goto Islands, Japan. J Gastroenterol. 2000;35:201-5. (Pubitemid 30195632)
19. McMahon BJ, Holck P, Bulkow L, Snowball M. Serologic and clinical outcomes of 1536 Alaska natives chronically infected with hepatitis B virus. Ann Intern Med. 2001;135:759-68. (Pubitemid 33051260)
20. Simonetti J, Bulkow L, McMahon BJ, Homan C, Snowball M, Negus S, et al. Clearance of hepatitis B surface antigen and risk of hepatocellular carcinoma in a cohort chronically infected with hepatitis B virus. Hepatology. 2010;51:1531-7.
21. Shiraki K, Yoshihara N, Sakurai M, Eto T, Kawana T. Acute hepatitis B in infants born to carrier mothers with the antibody to hepatitis B e antigen. J Pediatr. 1980;97:768-70. (Pubitemid 11216840)