Identification and characterization of potent CYP2D6 inhibitors in lotus leaves

Journal of Ethnopharmacology

Volumn 153, Issue 1, 2014, Pages 190-196

  Ye, Lin Hu ^a   He, Xiao Xi ^a   Kong, Ling Ti ^a   Liao, Yong Hong ^a   Pan, Rui Le ^a   Xiao, Bing Xin ^a   Liu, Xin Min ^a   Chang, Qi ^a  

^a INSTITUTE OF MEDICINAL PLANT DEVELOPMENT   (China)

Author keywords

Cytochrome P450; Herb drug interactions; Mechanism based inhibition; Nelumbo nucifera

Indexed keywords

2 HYDROXY 1 METHOXYAPORPHINE; ALKALOID DERIVATIVE; APORPHINE DERIVATIVE; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2D6 INHIBITOR; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; CYTOCHROME P450 INHIBITOR; NELUMBO NUCIFERA EXTRACT; NORNUCIFERINE; NUCIFERINE; UNCLASSIFIED DRUG; ALKALOID; CYTOCHROME P450; FLAVONOID; PLANT EXTRACT;

ARTICLE; CHEMICAL COMPOSITION; CONTROLLED STUDY; DRUG ISOLATION; DRUG STRUCTURE; ENZYME ACTIVITY; HERB DRUG INTERACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LIVER MICROSOME; NELUMBO NUCIFERA; NONHUMAN; PLANT LEAF; TANDEM MASS SPECTROMETRY; CHEMISTRY; DRUG EFFECTS; IC50; ISOLATION AND PURIFICATION; LIQUID CHROMATOGRAPHY; METABOLISM; NELUMBO; PROCEDURES;

NELUMBO NUCIFERA;

ALKALOIDS; CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 CYP2D6 INHIBITORS; CYTOCHROME P-450 ENZYME SYSTEM; FLAVONOIDS; HUMANS; INHIBITORY CONCENTRATION 50; MICROSOMES, LIVER; NELUMBO; PLANT EXTRACTS; PLANT LEAVES; TANDEM MASS SPECTROMETRY;

EID: 84897113289     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2014.02.014     Document Type: Article

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