Increased serum autotaxin levels in hepatocellular carcinoma patients were caused by background liver fibrosis but not by carcinoma

Clinica Chimica Acta

Volumn 433, Issue , 2014, Pages 128-134

  Kondo, Mayuko ^a   Ishizawa, Takeaki ^a   Enooku, Kenichiro ^a   Tokuhara, Yasunori ^a   Ohkawa, Ryunosuke ^a   Uranbileg, Baasanjav ^a   Nakagawa, Hayato ^a   Tateishi, Ryosuke ^a   Yoshida, Haruhiko ^a   Kokudo, Norihiro ^a   Koike, Kazuhiko ^a   Yatomi, Yutaka ^a   Ikeda, Hitoshi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Autotaxin; Hepatocellular carcinoma; Liver fibrosis; Lysophosphatidic acid

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ALPHA FETOPROTEIN; ASPARTATE AMINOTRANSFERASE; AUTOTAXIN; BILIRUBIN; COLLAGEN TYPE 7; GAMMA GLUTAMYLTRANSFERASE; HYALURONIC ACID BINDING PROTEIN; LYSOPHOSPHATIDIC ACID; MESSENGER RNA; ALKYLGLYCEROPHOSPHOETHANOLAMINE PHOSPHODIESTERASE; PHOSPHODIESTERASE;

AGED; ARTICLE; ASPARTATE AMINOTRANSFERASE TO PLATELET RATIO INDEX; CANCER TISSUE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HEPATOBILIARY PARAMETERS; HUMAN; HUMAN TISSUE; LIVER CELL CARCINOMA; LIVER FIBROSIS; LIVER RESECTION; LIVER STIFFNESS; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RADIOFREQUENCY ABLATION; THROMBOCYTE COUNT; TUMOR VOLUME; BLOOD; CARCINOMA, HEPATOCELLULAR; CATHETER ABLATION; COMPLICATION; GENE EXPRESSION REGULATION; GENETICS; LIVER CIRRHOSIS; LIVER NEOPLASMS; METABOLISM; PATHOLOGY;

AGED; CARCINOMA, HEPATOCELLULAR; CATHETER ABLATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; PHOSPHORIC DIESTER HYDROLASES; RNA, MESSENGER; TUMOR BURDEN;

EID: 84897106129     PISSN: 00098981     EISSN: 18733492     Source Type: Journal    
DOI: 10.1016/j.cca.2014.03.006     Document Type: Article

References (36)

1. Stracke M.L., Krutzsch H.C., Unsworth E.J., et al. Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein. J Biol Chem 1992, 267:2524-2529.
2. Stracke M.L., Clair T., Liotta L.A. Autotaxin, tumor motility-stimulating exophosphodiesterase. Adv Enzym Regul 1997, 37:135-144.
3. Baumforth K.R., Flavell J.R., Reynolds G.M., et al. Induction of autotaxin by the Epstein-Barr virus promotes the growth and survival of Hodgkin lymphoma cells. Blood 2005, 106:2138-2146. [Epub 2005 Jun 2132].
4. Kishi Y., Okudaira S., Tanaka M., et al. Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcholine to lysophosphatidic acid. J Biol Chem 2006, 281:17492-17500.
5. Yang Y., Mou L., Liu N., Tsao M.S. Autotaxin expression in non-small-cell lung cancer. Am J Respir Cell Mol Biol 1999, 21:216-222.
6. Stassar M.J., Devitt G., Brosius M., et al. Identification of human renal cell carcinoma associated genes by suppression subtractive hybridization. Br J Cancer 2001, 85:1372-1382.
7. Debies M.T., Welch D.R. Genetic basis of human breast cancer metastasis. J Mammary Gland Biol Neoplasia 2001, 6:441-451.
8. Kehlen A., Englert N., Seifert A., et al. Expression, regulation and function of autotaxin in thyroid carcinomas. Int J Cancer 2004, 109:833-838.
9. Tokumura A., Majima E., Kariya Y., et al. Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase. J Biol Chem 2002, 277:39436-39442.
10. Umezu-Goto M., Kishi Y., Taira A., et al. Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production. J Cell Biol 2002, 158:227-233.
11. Moolenaar W.H., van Meeteren L.A., Giepmans B.N. The ins and outs of lysophosphatidic acid signaling. Bioessays 2004, 26:870-881.
12. Aoki J., Taira A., Takanezawa Y., et al. Serum lysophosphatidic acid is produced through diverse phospholipase pathways. J Biol Chem 2002, 277:48737-48744. [Epub 42002 Sep 48726].
13. Tanaka M., Okudaira S., Kishi Y., et al. Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid. J Biol Chem 2006, 281:25822-25830.
14. Watanabe N., Ikeda H., Nakamura K., et al. Both plasma lysophosphatidic acid and serum autotaxin levels are increased in chronic hepatitis C. J Clin Gastroenterol 2007, 41:616-623.
15. Watanabe N., Ikeda H., Nakamura K., et al. Plasma lysophosphatidic acid level and serum autotaxin activity are increased in liver injury in rats in relation to its severity. Life Sci 2007, 81:1009-1015.
16. Zhang G., Zhao Z., Xu S., Ni L., Wang X. Expression of autotaxin mRNA in human hepatocellular carcinoma. Chin Med J 1999, 112:330-332.
17. Cooper A.B., Wu J., Lu D., Maluccio M.A. Is autotaxin (ENPP2) the link between hepatitis C and hepatocellular cancer?. J Gastrointest Surg 2007, 11:1628-1634. [discussion 1634-1625].
18. Mazzocca A., Dituri F., Lupo L., Quaranta M., Antonaci S., Giannelli G. Tumor-secreted lysophostatidic acid accelerates hepatocellular carcinoma progression by promoting differentiation of peritumoral fibroblasts in myofibroblasts. Hepatology 2011, 54:920-930.
19. Wu J.M., Xu Y., Skill N.J., et al. Autotaxin expression and its connection with the TNF-alpha-NF-kappaB axis in human hepatocellular carcinoma. Mol Cancer 2010, 9:71.
20. Ikeda H., Enooku K., Ohkawa R., Koike K., Yatomi Y. Plasma lysophosphatidic acid levels and hepatocellular carcinoma. Hepatology 2013, 57:417-418.
21. Torzilli G., Minagawa M., Takayama T., et al. Accurate preoperative evaluation of liver mass lesions without fine-needle biopsy. Hepatology 1999, 30:889-893.
22. Tateishi R., Shiina S., Teratani T., et al. Percutaneous radiofrequency ablation for hepatocellular carcinoma. An analysis of 1000 cases. Cancer 2005, 103:1201-1209.
23. Teratani T., Yoshida H., Shiina S., et al. Radiofrequency ablation for hepatocellular carcinoma in so-called high-risk locations. Hepatology 2006, 43:1101-1108.
24. Nakamura K., Igarashi K., Ide K., et al. Validation of an autotaxin enzyme immunoassay in human serum samples and its application to hypoalbuminemia differentiation. Clin Chim Acta 2008, 388:51-58.
25. Castera L., Vergniol J., Foucher J., et al. Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C. Gastroenterology 2005, 128:343-350.
26. Lebray P., Varnous S., Charlotte F., Varaut A., Poynard T., Ratziu V. Liver stiffness is an unreliable marker of liver fibrosis in patients with cardiac insufficiency. Hepatology 2008, 48:2089.
27. Sagir A., Erhardt A., Schmitt M., Haussinger D. Transient elastography is unreliable for detection of cirrhosis in patients with acute liver damage. Hepatology 2008, 47:592-595.
28. El-Serag H.B., Rudolph K.L. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 2007, 132:2557-2576.
29. Nakamura K., Ohkawa R., Okubo S., et al. Measurement of lysophospholipase D/autotaxin activity in human serum samples. Clin Biochem 2007, 40:274-277.
30. Nakagawa H., Ikeda H., Nakamura K., et al. Autotaxin as a novel serum marker of liver fibrosis. Clin Chim Acta 2011, 412:1201-1206.
31. Stefan C., Gijsbers R., Stalmans W., Bollen M. Differential regulation of the expression of nucleotide pyrophosphatases/phosphodiesterases in rat liver. Biochim Biophys Acta 1999, 1450:45-52.
32. Jansen S., Andries M., Vekemans K., Vanbilloen H., Verbruggen A., Bollen M. Rapid clearance of the circulating metastatic factor autotaxin by the scavenger receptors of liver sinusoidal endothelial cells. Cancer Lett 2009, 284:216-221.
33. Muro H., Shirasawa H., Kosugi I., Nakamura S. Defect of Fc receptors and phenotypical changes in sinusoidal endothelial cells in human liver cirrhosis. Am J Pathol 1993, 143:105-120.
34. Genda T., Sakamoto M., Ichida T., et al. Cell motility mediated by rho and Rho-associated protein kinase plays a critical role in intrahepatic metastasis of human hepatocellular carcinoma. Hepatology 1999, 30:1027-1036.
35. Ayaki M., Mukai M., Imamura F., et al. Cooperation of fibronectin with lysophosphatidic acid induces motility and transcellular migration of rat ascites hepatoma cells. Biochim Biophys Acta 2000, 1495:40-50.
36. Sokolov E., Eheim A.L., Ahrens W.A., et al. Lysophosphatidic acid receptor expression and function in human hepatocellular carcinoma. J Surg Res 2013, 180:104-113.