Imaging changes following stereotactic radiosurgery for metastatic intracranial tumors: Differentiating pseudoprogression from tumor progression and its effect on clinical practice

Neurosurgical Review

Volumn 37, Issue 2, 2014, Pages 193-201

  Ruzevick, Jacob ^a   Kleinberg, Lawrence ^a   Rigamonti, Daniele ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Brain metastases; Pseudoprogression; Stereotactic radiosurgery

Indexed keywords

BRAIN BLOOD FLOW; BRAIN METASTASIS; CANCER DIAGNOSIS; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER SURVIVAL; DIAGNOSTIC IMAGING; HUMAN; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; REVIEW; SENSITIVITY AND SPECIFICITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; STEREOTACTIC RADIOSURGERY; SURVIVAL RATE; SURVIVAL TIME; TUMOR GROWTH; TUMOR VASCULARIZATION; BRAIN NEOPLASMS; DISEASE COURSE; NEOPLASM RECURRENCE, LOCAL; PROCEDURES; RADIOSURGERY; SECONDARY;

BRAIN NEOPLASMS; DISEASE PROGRESSION; HUMANS; NEOPLASM RECURRENCE, LOCAL; RADIOSURGERY;

EID: 84897104049     PISSN: 03445607     EISSN: 14372320     Source Type: Journal    
DOI: 10.1007/s10143-013-0504-8     Document Type: Review

References (90)

1. Alexiou GA, Fotopoulos AD, Papadopoulos A, Kyritsis AP, Polyzoidis KS, Tsiouris S (2007) Evaluation of brain tumor recurrence by (99 m)Tc-tetrofosmin SPECT: a prospective pilot study. Ann Nucl Med 21:293-298 (Pubitemid 350104527)
2. Aoyama H, Shirato H, Tago M, Nakagawa K, Toyoda T, Hatano K et al (2006) Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trial. JAMA: J Am Med Assoc 295:2483-2491 (Pubitemid 43854963)
3. Aoyama H, Tago M, Kato N, Toyoda T, Kenjyo M, Hirota S et al (2007) Neurocognitive function of patients with brainmetastasis who received either whole brain radiotherapy plus stereotactic radiosurgery or radiosurgery alone. Int J Radiat Oncol, Biol, Phys 68:1388-1395 (Pubitemid 47176822)
4. Babu R, Huang PP, Epstein F, Budzilovich GN (1993) Late radiation necrosis of the brain: case report. J Neuro-Oncol 17:37-42 (Pubitemid 24006747)
5. Barajas RF, Chang JS, Sneed PK, Segal MR, McDermott MW, Cha S (2009) Distinguishing recurrent intra-axial metastatic tumor from radiation necrosis following Gamma Knife radiosurgery using dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging. AJNR Am J Neuroradiol 30:367-372
6. Belohlavek O, Simonova G, Kantorova I, Novotny J Jr, Liscak R (2003) Brain metastases after stereotactic radiosurgery using the Leksell Gamma Knife: can FDG PET help to differentiate radionecrosis from tumour progression? Eur J Nucl Med Mol Imaging 30:96-100 (Pubitemid 36692898)
7. Brandes AA, Franceschi E, Tosoni A, Blatt V, Pession A, Tallini G et al (2008) MGMT promoter methylation status can predict the incidence and outcome of pseudoprogression after concomitant radiochemotherapy in newly diagnosed glioblastoma patients. J Clin Oncol : Off J Am Soc Clin Oncol 26:2192-2197
8. Chamberlain MC, Glantz MJ, Chalmers L, Van Horn A, Sloan AE (2007) Early necrosis following concurrent Temodar and radiotherapy in patients with glioblastoma. J Neuro-oncol 82:81-83
9. Chen W, Silverman DH, Delaloye S, Czernin J, Kamdar N, Pope W et al (2006) 18F-FDOPA PET imaging of brain tumors: comparison study with 18F-FDG PET and evaluation of diagnostic accuracy. J Nucl Med : Off Publ Soc Nucl Med 47:904-911 (Pubitemid 46939941)
10. Chernov MF, Hayashi M, Izawa M, Usukura M, Yoshida S, Ono Y et al (2006) Multivoxel proton MRS for differentiation of radiation-induced necrosis and tumor recurrence after Gamma Knife radiosurgery for brain metastases. Brain Tumor Pathol 23:19-27 (Pubitemid 44576307)
11. Choi SJ, Kim JS, Kim JH, Oh SJ, Lee JG, Kim CJ et al (2005) [18F]3′-deoxy-3′-fluorothymidine PET for the diagnosis and grading of brain tumors. Eur J Nucl Med Mol Imaging 32:653-659
12. Chung JK, Kim YK, Kim SK, Lee YJ, Paek S, Yeo JS et al (2002) Usefulness of 11C-methionine PET in the evaluation of brain lesions that are hypo- or isometabolic on 18F-FDG PET. Eur J Nucl Med Mol Imaging 29:176-182
13. Combs SE, Schulz-Ertner D, Thilmann C, Edler L, Debus J (2004) Treatment of cerebral metastases from breast cancer with stereotactic radiosurgery. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 180:590-596
14. Croteau D, Scarpace L, Hearshen D, Gutierrez J, Fisher JL, Rock JP et al (2001) Correlation between magnetic resonance spectroscopy imaging and image-guided biopsies: semiquantitative and qualitative histopathological analyses of patients with untreated glioma. Neurosurgery 49:823-829 (Pubitemid 32927953)
15. Da Silva AN, Nagayama K, Schlesinger D, Sheehan JP (2009) Early brain tumor metastasis reduction following Gamma Knife surgery. J Neurosurg 110:547-552
16. Datta R, Jawahar A, Ampil FL, Shi R, Nanda A, D'Agostino H (2004) Survival in relation to radiotherapeutic modality for brain metastasis: whole brain irradiation vs. Gamma Knife radiosurgery. Am J Clin Oncol 27:420-424 (Pubitemid 39045256)
17. DeWitte O, Goldberg I, Wikler D, Rorive S, Damhaut P, Monclus M et al (2001) Positron emission tomography with injection of methionine as a prognostic factor in glioma. J Neurosurg 95:746-750 (Pubitemid 33043345)
18. Delsanti C, Roche PH, Thomassin JM, Regis J (2008) Morphological changes of vestibular schwannomas after radiosurgical treatment: pitfalls and diagnosis of failure. Prog Neurol Surg 21:93-97
19. Dequesada IM, Quisling RG, Yachnis A, Friedman WA (2008) Can standard magnetic resonance imaging reliably distinguish recurrent tumor fromradiation necrosis after radiosurgery for brainmetastases? A radiographic-pathological study. Neurosurg 63:898-903, discussion 904
20. Dhermain FG, Hau P, Lanfermann H, Jacobs AH, van den Bent MJ (2010) Advanced MRI and PET imaging for assessment of treatment response in patients with gliomas. Lancet Neurol 9:906-920
21. Dowling C, Bollen AW, Noworolski SM, McDermott MW, Barbaro NM, Day MR et al (2001) Preoperative proton MR spectroscopic imaging of brain tumors: correlation with histopathologic analysis of resection specimens. AJNR Am J Neuroradiol 22:604-612 (Pubitemid 32318684)
22. Endo K, Yui N, Suzuki K, Torizuka K (1994) [Clinical usefulness of thallium-201 chloride in the diagnosis of tumors (I)-Evaluation in brain tumors]. Kaku igaku Jpn J Nucl Med 31:53-61 (Pubitemid 24077597)
23. Esteve F, Rubin C, Grand S, Kolodie H, Le Bas JF (1998) Transient metabolic changes observed with proton MR spectroscopy in normal human brain after radiation therapy. Int J Radiat Oncol, Biol, Phys 40: 279-286 (Pubitemid 28114369)
24. Gavrilovic IT, Posner JB (2005) Brain metastases: epidemiology and pathophysiology. J Neuro-Oncol 75:5-14 (Pubitemid 41548673)
25. Gomez-Rio M, Rodriguez-Fernandez A, Ramos-Font C, Lopez-Ramirez E, Llamas-Elvira JM (2008) Diagnostic accuracy of 201Thallium-SPECT and 18F-FDG-PET in the clinical assessment of glioma recurrence. Eur J nucl Med Mol Imaging 35:966-975
26. Gunjur A, Lau E, Taouk Y, Ryan G (2011) Early post-treatment pseudo-progression amongst glioblastoma multiforme patients treated with radiotherapy and temozolomide: a retrospective analysis. J Med Imaging and Radiat Oncol 55:603-610
27. Hasegawa T, Kida Y, Yoshimoto M, Koike J, Goto K (2006) Evaluation of tumor expansion after stereotactic radiosurgery in patients harboring vestibular schwannomas. Neurosurg 58:1119-1128, discussion 1119-1128
28. Hayhurst C, Zadeh G (2012) Tumor pseudoprogression following radiosurgery for vestibular schwannoma. Neuro-Oncol 14:87-92
29. Hoefnagels FW, Lagerwaard FJ, Sanchez E, Haasbeek CJ, Knol DL, Slotman BJ et al (2009) Radiological progression of cerebral metastases after radiosurgery: assessment of perfusion MRI for differentiating between necrosis and recurrence. J Neurol 256:878-887
30. Hoffman WF, Levin VA, Wilson CB (1979) Evaluation of malignant glioma patients during the postirradiation period. J Neurosurg 50:624-628 (Pubitemid 9178240)
31. Huang J, Wang AM, Shetty A, Maitz AH, Yan D, Doyle D et al (2011) Differentiation between intra-axial metastatic tumor progression and radiation injury following fractionated radiation therapy or stereotactic radiosurgery using MR spectroscopy, perfusion MR imaging or volume progression modeling. Magn Reson Imaging 29:993-1001
32. Huber PE, Hawighorst H, Fuss M, van Kaick G, Wannenmacher MF, Debus J (2001) Transient enlargement of contrast uptake on MRI after linear accelerator (linac) stereotactic radiosurgery for brain metastases. Inter J Radiat Oncol, Biol, Phys 49:1339-1349 (Pubitemid 32294314)
33. Jagannathan J, Bourne TD, Schlesinger D, Yen CP, Shaffrey ME, Laws ER Jr et al (2010) Clinical and pathological characteristics of brain metastasis resected after failed radiosurgery. Neurosurgery 66:208-217
34. Jensen RL (2009) Brain tumor hypoxia: tumorigenesis, angiogenesis, imaging, pseudoprogression, and as a therapeutic target. J Neuro-Oncol 92:317-335
35. Kaminaga T, Shirai K (2005) Radiation-induced brain metabolic changes in the acute and early delayed phase detected with quantitative proton magnetic resonance spectroscopy. J Comput Assist Tomogr 29:293-297 (Pubitemid 40734585)
36. Kamiryo T, Lopes MB, Kassell NF, Steiner L, Lee KS (2001) Radiosurgery-induced microvascular alterations precede necrosis of the brain neuropil. Neurosurgery 49:409-414, discussion 414-405
37. Kang HC, Kim CY, Han JH, Choe GY, Kim JH, Kim IA (2011) Pseudoprogression in patients with malignant gliomas treated with concurrent temozolomide and radiotherapy: potential role of p53. J Neuro-Oncol 102:157-162
38. Kanner AA, Suh JH, Siomin VE, Lee SY, Barnett GH, Vogelbaum MA (2003) Posterior fossa metastases: aggressive treatment improves survival. Stereotact Funct Neurosurg 81:18-23 (Pubitemid 38209810)
39. Kano H, Kondziolka D, Lobato-Polo J, Zorro O, Flickinger JC, Lunsford LD (2010) T1/T2 matching to differentiate tumor growth from radiation effects after stereotactic radiosurgery. Neurosurg 66: 486-491, discussion 491-482
40. Kawabata S, Hiramatsu R, Kuroiwa T, Ono K, Miyatake SI (2013) Boron neutron capture therapy for recurrent high-grade meningiomas. J Neurosurg 119(4):837-844
41. Kelly PJ, Weiss SE, Sher DJ, Perez-Atayde AR, Dal Cin P, Choueiri TK (2010) Sunitinib-induced pseudoprogression after whole-brain radiotherapy for metastatic renal cell carcinoma. J Clin Oncol : Off J Am Soc Clin Oncol 28:e433-e435
42. Kimura T, Sako K, Tohyama Y, Aizawa S, Yoshida H, Aburano T et al (2003) Diagnosis and treatment of progressive space-occupying radiation necrosis following stereotactic radiosurgery for brain metastasis: value of proton magnetic resonance spectroscopy. Acta neurochirurgica 145:557-564, discussion 564
43. Kocher M, Maarouf M, Bendel M, Voges J, Muller RP, Sturm V (2004) Linac radiosurgery versus whole brain radiotherapy for brain metastases. A survival comparison based on the RTOG recursive partitioning analysis. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 180:263-267
44. Lamy-Lhullier C, Dubois F, Blond S, Lecouffe P, Steinling M (1999) Importance of cerebral tomoscintigraphy using technetium-labeled sestamibi in the differential diagnosis of current tumor vs. radiation necrosis in subtentorial glial tumors in the adult. Neuro-Chirurgie 45: 110-117
45. Law M, Cha S, Knopp EA, Johnson G, Arnett J, Litt AW (2002) High-grade gliomas and solitary metastases: differentiation by using perfusion and proton spectroscopic MR imaging. Radiology 222: 715-721 (Pubitemid 34215219)
46. Le Jeune FP, Dubois F, Blond S, Steinling M (2006) Sestamibi technetium-99 m brain single-photon emission computed tomography to identify recurrent glioma in adults: 201 studies. J Neuro-Oncol 77:177-183 (Pubitemid 44419753)
47. Lindvall P, Bergstrom P, Lofroth PO, Henriksson R, Bergenheim AT (2005) Hypofractionated conformal stereotactic radiotherapy alone or in combination with whole-brain radiotherapy in patients with cerebral metastases. Int J Radiat Oncol, Biol, Phys 61:1460-1466 (Pubitemid 40470429)
48. Long DM (1979) Capillary ultrastructure in human metastatic brain tumors. J Neurosurg 51:53-58
49. Lupo JM, Cha S, Chang SM, Nelson SJ (2005) Dynamic susceptibility- weighted perfusion imaging of high-grade gliomas: characterization of spatial heterogeneity. AJNR Am J Neuroradiol 26:1446-1454 (Pubitemid 43733445)
50. Meijer OW, Weijmans EJ, Knol DL, Slotman BJ, Barkhof F, Vandertop WP et al (2008) Tumor-volume changes after radiosurgery for vestibular schwannoma: implications for follow-up MR imaging protocol. AJNR Am J Neuroradiol 29:906-910 (Pubitemid 351684964)
51. Meyer MA, Frey KA, Schwaiger M (1993) Discordance between F-18 fluorodeoxyglucose uptake and contrast enhancement in a brain abscess. Clin Nucl Med 18:682-684 (Pubitemid 23229604)
52. Mitsuya K, Nakasu Y, Horiguchi S, Harada H, Nishimura T, Bando E et al (2010) Perfusion weighted magnetic resonance imaging to distinguish the recurrence of metastatic brain tumors from radiation necrosis after stereotactic radiosurgery. J Neuro-Oncol 99:81-88
53. Miyatake S, Kawabata S, Nonoguchi N, Yokoyama K, Kuroiwa T, Matsui H et al (2009) Pseudoprogression in boron neutron capture therapy for malignant gliomas and meningiomas. Neuro-Oncol 11:430-436
54. Muller-Riemenschneider F, Bockelbrink A, Ernst I, Schwarzbach C, Vauth C, von der Schulenburg JM et al (2009) Stereotactic radiosurgery for the treatment of brain metastases. Radiother Oncol : J Eur Soc Ther Radiol Oncol 91:67-74
55. Nagano O, Higuchi Y, Serizawa T, Ono J, Matsuda S, Yamakami I et al (2008) Transient expansion of vestibular schwannoma following stereotactic radiosurgery. J Neurosurg 109:811-816
56. Nakamura H, Jokura H, Takahashi K, Boku N, Akabane A, Yoshimoto T (2000) Serial follow-up MR imaging after Gamma Knife radiosurgery for vestibular schwannoma. AJNR Am J Neuroradiol 21:1540-1546
57. Noel G, Medioni J, Valery CA, Boisserie G, Simon JM, Cornu P et al (2003) Three irradiation treatment options including radiosurgery for brain metastases from primary lung cancer. Lung Cancer 41:333-343 (Pubitemid 36974560)
58. O'Neill BP, Iturria NJ, Link MJ, Pollock BE, Ballman KV, O'Fallon JR (2003) A comparison of surgical resection and stereotactic radio-surgery in the treatment of solitary brain metastases. Int J Radiat Oncol, Biol, Phys 55:1169-1176 (Pubitemid 36338280)
59. Okunaga T, Matsuo T, Hayashi N, Hayashi Y, Shabani HK, Kaminogo M et al (2005) Linear accelerator radiosurgery for vestibular schwannoma: measuring tumor volume changes on serial three-dimensional spoiled gradient-echo magnetic resonance images. J Neurosurg 103:53-58 (Pubitemid 43193934)
60. Okwan-Duodu D, Pollack BP, Lawson D, Khan MK (2013) Role of Radiation Therapy as Immune Activator in the Era of Modern Immunotherapy for Metastatic Malignant Melanoma. Am J Clin Oncol. doi:10.1097/COC.0b013e3182940dc3
61. Palumbo B, Lupattelli M, Pelliccioli GP, Chiarini P, Moschini TO, Palumbo I et al (2006) Association of 99mTc-MIBI brain SPECTand proton magnetic resonance spectroscopy (1H-MRS) to assess glioma recurrence after radiotherapy. The Q J Nucl Med Mol Imaging : Off Publ Ital Ass Nucl Med 50:88-93
62. Patel TR, McHugh BJ, Bi WL, Minja FJ, Knisely JP, Chiang VL (2011) A comprehensive review of MR imaging changes following radiosurgery to 500 brain metastases. AJNR Am J Neuroradiol 32:1885-1892
63. Pollock BE (2006) Management of vestibular schwannomas that enlarge after stereotactic radiosurgery: treatment recommendations based on a 15 year experience. Neurosurg 58:241-248, discussion 241-248
64. Rades D, Bohlen G, Pluemer A, Veninga T, Hanssens P, Dunst J et al (2007) Stereotactic radiosurgery alone versus resection plus whole-brain radiotherapy for 1 or 2 brainmetastases in recursive partitioning analysis class 1 and 2 patients. Cancer 109:2515-2521 (Pubitemid 46906471)
65. Rades D, Pluemer A, Veninga T, Hanssens P, Dunst J, Schild SE (2007)Whole-brain radiotherapy versus stereotactic radiosurgery for patients in recursive partitioning analysis classes 1 and 2 with 1 to 3 brain metastases. Cancer 110:2285-2292 (Pubitemid 350100751)
66. Rock JP, Hearshen D, Scarpace L, Croteau D, Gutierrez J, Fisher JL et al (2002) Correlations between magnetic resonance spectroscopy and image-guided histopathology, with special attention to radiation necrosis. Neurosurg 51:912-919, discussion 919-920
67. Sanghera P, Perry J, Sahgal A, Symons S, Aviv R, Morrison M et al (2010) Pseudoprogression following chemoradiotherapy for glioblastoma multiforme. Can J Neurol Sci Le journal canadien des sciences neurologiques 37:36-42
68. Schlemmer HP, Bachert P, Henze M, Buslei R, Herfarth KK, Debus J et al (2002) Differentiation of radiation necrosis from tumor progression using proton magnetic resonance spectroscopy. Neuroradiology 44:216-222 (Pubitemid 36075911)
69. Schlemmer HP, Bachert P, Herfarth KK, Zuna I, Debus J, van Kaick G (2001) Proton MR spectroscopic evaluation of suspicious brain lesions after stereotactic radiotherapy. AJNR Am J Neuroradiol 22: 1316-1324 (Pubitemid 32734804)
70. Schouten LJ, Rutten J, Huveneers HA, Twijnstra A (2002) Incidence of brain metastases in a cohort of patients with carcinoma of the breast, colon, kidney, and lung and melanoma. Cancer 94:2698-2705 (Pubitemid 34478086)
71. Serizawa T, Saeki N, Higuchi Y, Ono J, Matsuda S, Sato M et al (2005) Diagnostic value of thallium-201 chloride single-photon emission computerized tomography in differentiating tumor recurrence from radiation injury after Gamma Knife surgery for metastatic brain tumors. J Neurosurg 102(Suppl):266-271 (Pubitemid 44783967)
72. Shehata MK, Young B, Reid B, Patchell RA, St Clair W, Sims J et al (2004) Stereotatic radiosurgery of 468 brain metastases < or =2 cm: implications for SRS dose and whole brain radiation therapy. Int J Radiat Oncol, Biol, Phys 59:87-93 (Pubitemid 38501511)
73. Siomin VE, Vogelbaum MA, Kanner AA, Lee SY, Suh JH, Barnett GH (2004) Posterior fossa metastases: risk of leptomeningeal disease when treated with stereotactic radiosurgery compared to surgery. J Neuro-Oncol 67:115-121 (Pubitemid 38418257)
74. Smith EA, Carlos RC, Junck LR, Tsien CI, Elias A, Sundgren PC (2009) Developing a clinical decision model: MR spectroscopy to differentiate between recurrent tumor and radiation change in patients with new contrast-enhancing lesions. AJR Am J Roentgenol 192:W45-52
75. Sneed PK, Suh JH, Goetsch SJ, Sanghavi SN, Chappell R, Buatti JM et al (2002) A multi-institutional review of radiosurgery alone vs. radiosurgery with whole brain radiotherapy as the initial management of brain metastases. Int J Radiat Oncol, Biol, Phys 53:519-526 (Pubitemid 34626488)
76. Soffietti R, Ruda R, Trevisan E (2008) Brain metastases: current management and new developments. Curr Opin in Oncol 20:676-684
77. Spence AM, Muzi M, Link JM, O'Sullivan F, Eary JF, Hoffman JM et al (2009) NCI-sponsored trial for the evaluation of safety and preliminary efficacy of 3′-deoxy-3′-[18F]fluorothymidine (FLT) as a marker of proliferation in patients with recurrent gliomas: preliminary efficacy studies. Mol Imaging Biol : MIB : Off Publ Acad Mol Imaging 11:343-355
78. Stamell EF, Wolchok JD, Gnjatic S, Lee NY, Brownell I (2013) The abscopal effect associated with a systemic anti-melanoma immune response. Int J Radiat Oncol, Biol, Phys 85:293-295
79. Stockham AL, Tievsky AL, Koyfman SA, Reddy CA, Suh JH, Vogelbaum MA et al (2012) Conventional MRI does not reliably distinguish radiation necrosis from tumor recurrence after stereotactic radiosurgery. J Neuro-Oncol 109:149-158
80. Sul J, Posner JB (2007) Brain metastases: epidemiology and pathophysiology. Cancer Treat Res 136:1-21
81. Sundgren PC (2009)MR spectroscopy in radiation injury. AJNR Am J Neuroradiol 30:1469-1476
82. Sundgren PC, Nagesh V, Elias A, Tsien C, Junck L, Gomez Hassan DM et al (2009) Metabolic alterations: a biomarker for radiation-induced normal brain injury-an MR spectroscopy study. J Magn Reson Imaging : JMRI 29:291-297
83. Taal W, Brandsma D, de Bruin HG, Bromberg JE, Swaak-Kragten AT, Smitt PA et al (2008) Incidence of early pseudo-progression in a cohort of malignant glioma patients treated with chemoirradiation with temozolomide. Cancer 113:405-410
84. Terakawa Y, Tsuyuguchi N, Iwai Y, Yamanaka K, Higashiyama S, Takami T et al (2008) Diagnostic accuracy of 11C-methionine PET for differentiation of recurrent brain tumors from radiation necrosis after radiotherapy. J Nucl Med : Off Publ Soc Nucl Med 49:694-699 (Pubitemid 351717532)
85. Tie J, Gunawardana DH, Rosenthal MA (2008) Differentiation of tumor recurrence fromradiation necrosis in high-grade gliomas using 201Tl-SPECT. J Clin Neurosci : Off J Neurosurg Soc Australas 15: 1327-1334
86. Tsuyuguchi N, Sunada I, Iwai Y, Yamanaka K, Tanaka K, Takami T et al (2003) Methionine positron emission tomography of recurrent metastatic brain tumor and radiation necrosis after stereotactic radiosurgery: is a differential diagnosis possible? J Neurosurg 98:1056-1064 (Pubitemid 36460897)
87. Van Laere K, Ceyssens S, Van Calenbergh F, de Groot T, Menten J, Flamen P et al (2005) Direct comparison of 18F-FDG and 11C-methionine PET in suspected recurrence of glioma: sensitivity, inter-observer variability and prognostic value. Eur J Nucl Med Mol Imaging 32:39-51 (Pubitemid 40142777)
88. Weybright P, Sundgren PC, Maly P, Hassan DG, Nan B, Rohrer S et al (2005) Differentiation between brain tumor recurrence and radiation injury using MR spectroscopy. AJR Am J Roentgenol 185:1471-1476
89. Yu CP, Cheung JY, Leung S, Ho R (2000) Sequential volume mapping for confirmation of negative growth in vestibular schwannomas treated by Gamma Knife radiosurgery. J Neurosurg 93(Suppl 3):82-89 (Pubitemid 32799551)
90. Zwolak P, Jasinski P, Terai K, Gallus NJ, Ericson ME, Clohisy DR et al (2008) Addition of receptor tyrosine kinase inhibitor to radiation increases tumour control in an orthotopic murine model of breast cancer metastasis in bone. Eur J Cancer 44:2506 - 2517