A computational model for the optimization of transport phenomena in a rotating hollow-fiber bioreactor for artificial liver

Tissue Engineering - Part C: Methods

Volumn 15, Issue 1, 2009, Pages 41-55

  Consolo, Filippo ^a   Fiore, Gianfranco B ^b   Truscello, Silvia ^b   Caronna, Marco ^c   Morbiducci, Umberto ^a   Montevecchi, Franco M ^a   Redaelli, Alberto ^b  

^a POLITECNICO DI TORINO   (Italy)

^b POLITECNICO DI MILANO   (Italy)

^c FRESENIUS MEDICAL CARE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARTIFICIAL ORGANS; BIOLOGICAL MATERIALS PRESERVATION; BIOREACTORS; CELL MEMBRANES; COMPUTATIONAL FLUID DYNAMICS; COMPUTER AIDED DESIGN; FLUID DYNAMICS; FLUIDS; INDUSTRIAL CHEMICALS; LIVER; MULTIPHASE FLOW; OXYGEN; ROTATION; STRESSES; SUSPENSIONS (FLUIDS); THREE DIMENSIONAL; TRANSPORT PROPERTIES;

ARTIFICIAL LIVER; COMPUTATIONAL MODEL; COMPUTATIONAL STUDIES; CRITICAL THRESHOLD VALUE; CULTURE MEDIUM; CULTURED CELL; HEPATOCYTES; HOLLOW FIBER BIOREACTOR; HOMOGENEOUS DISTRIBUTION; INDUCED STRESS; INITIAL VALUES; LIVER-SPECIFIC FUNCTIONS; MECHANICAL STRESS; METABOLIC ACTIVITY; MICROCARRIER; MULTIPHASE FLUIDS; NUMERICAL SIMULATION; PARTIAL PRESSURE OF OXYGEN; ROTATING FLUIDS; ROTATIONAL SPEED; TIME-DEPENDENT; TRANSPORT PHENOMENA;

CELL CULTURE;

ARTICLE; ARTIFICIAL LIVER; CELL HYPOXIA; CELL METABOLISM; CELL STRESS; CELLULAR DISTRIBUTION; COMPUTATIONAL FLUID DYNAMICS; COMPUTER AIDED DESIGN; CULTURE MEDIUM; DIFFUSION; FLOW RATE; HOLLOW FIBER REACTOR; LIVER CELL; LIVER CELL CULTURE; LIVER FUNCTION; MATHEMATICAL MODEL; MECHANICAL STRESS; OXYGEN CONSUMPTION; OXYGEN SUPPLY; OXYGEN TENSION; PRIORITY JOURNAL; SIMULATION; THERMODYNAMICS; BIOREACTOR; CLINICAL TRIAL; COMPUTER SIMULATION; FLOW KINETICS; PRESSURE; ROTATION; TRANSPORT AT THE CELLULAR LEVEL; ULTRAFILTRATION; WEIGHTLESSNESS;

OXYGEN;

BIOLOGICAL TRANSPORT; BIOREACTORS; CLINICAL TRIALS AS TOPIC; COMPUTER SIMULATION; LIVER, ARTIFICIAL; OXYGEN; PARTIAL PRESSURE; RHEOLOGY; ROTATION; STRESS, MECHANICAL; ULTRAFILTRATION; WEIGHTLESSNESS;

EID: 66149088540     PISSN: 19373384     EISSN: 19373392     Source Type: Journal    
DOI: 10.1089/ten.tec.2008.0213     Document Type: Article

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