Synthesis, cytotoxicity and molecular modelling studies of new phenylcinnamide derivatives as potent inhibitors of cholinesterases

European Journal of Medicinal Chemistry

Volumn 78, Issue , 2014, Pages 43-53

  Saeed, Aamer ^a   Mahesar, Parvez Ali ^a   Zaib, Sumera ^b   Khan, Muhammad Siraj ^b   Matin, Abdul ^c   Shahid, Mohammad ^d   Iqbal, Jamshed ^b  

^a QUAID I AZAM UNIVERSITY   (Pakistan)

^b Centre for Advanced Drug Research COMSATS Institute of Information Technology ^*  (Pakistan)

^c INSTITUTE OF BIOMEDICAL AND GENETIC ENGINEERING IBGE   (Pakistan)

^d FRAUNHOFER INSTITUTE FOR ALGORITHMS AND SCIENTIFIC COMPUTING SCAI   (Germany)

Author keywords

Alzheimer's disease; Cholinesterases inhibitors; Cytotoxicity; Molecular docking; Phenylcinnamide derivatives

Indexed keywords

(3 NITROPHENYL) N (3,4,5 TRIMETHOXYPHENYL)ACRYLAMIDE; 2 METHOXY 4 [3 OXO 3 (3,4,5 TRIMETHOXYPHENYLAMINO)PROP 1 ENYL]PHENYL ACETATE; 3 (2 CHLORO 6 NITROPHENYL) N (3,4,5 TRIMETHOXYPHENYL)ACRYLAMIDE; 3 (2 HYDROXY 3 METHOXYPHENYL) N (3,4,5 TRIMETHOXYPHENYL)ACRYLAMIDE; 3 (2 HYDROXY 6 NITROPHENYL) N (3,4,5 TRIMETHOXYPHENYL)ACRYLAMIDE; 3 (2,3 DIHYDROXYPHENYL) N (3,4,5 TRIMETHOXYPHENYL)ACRYLAMIDE; 3 (2,4 DIHYDROXYPHENYL) N (3,4,5 TRIMETHOXYPHENYL)ACRYLAMIDE; 3 (2,6 DIHYDROXYPHENYL) N (3,4,5 TRIMETHOXYPHENYL)ACRYLAMIDE; 3 (3 HYDROXY 4 METHOXYPHENYL) N (3,4,5 TRIMETHOXYPHENYL)ACRYLAMIDE; 3 (4 CHLOROPHENYL) N (3,4,5 TRIMETHOXYPHENYL)ACRYLAMIDE; 3 (4 METHOXYPHENYL) N (3,4,5 TRIMETHOXYPHENYL)ACRYLAMIDE; 3 [2 (ALLYLOXY) PHENYL] N (3,4,5 TRIMETHOXYPHENYL)ACRYLAMIDE; 3 [2 (BENZYLOXY) PHENYL] N (3,4,5 TRIMETHOXYPHENYL)ACRYLAMIDE; 3 [2 (BENZYLOXY)PHENYL] N (3,4,5 TRIMETHOXYPHENYL)ACRYLAMIDE; 3 [3 (BENZYLOXY) 4 METHOXYPHENYL] N (3,4,5 TRIMETHOXYPHENYL)ACRYLAMIDE; 3 [3 (BENZYLOXY)PHENYL] N (3,4,5 TRIMETHOXYPHENYL) ACRYLAMIDE; 3 [3 OXO 3 (3,4,5 TRIMETHOXYPHENYLAMINO)PROP 1 ENYL]PHENYL ACETATE; 3 [4 (ACETOXYAMINO)PHENYL] N (3,4,5 TRIMETHOXYPHENYL) ACRYLAMIDE; 3 [4 (ALLYLOXY)PHENYL] N (3,4,5 TRIMETHOXYPHENYL)ACRYLAMIDE; 3 [4 (BENZYLOXY) 2 HYDROXYPHENYL] N (3,4,5 TRIMETHOXYPHENYL)ACRYLAMIDE; 3 [4 (BENZYLOXY) 3 METHOXYPHENYL] N (3,4,5 TRIMETHOXYPHENYL)ACRYLAMIDE; 4 [3 OXO 3 (3,4,5 TRIMETHOXYPHENYLAMINO)PROP 1 ENYL]PHENYL ACETATE; ACETYLCHOLINESTERASE; ANTINEOPLASTIC AGENT; BENZENE DERIVATIVE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; PHENYLCINNAMIDE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINCRISTINE; AMIDE;

ALZHEIMER DISEASE; ARTICLE; CANCER CELL CULTURE; CHOLINESTERASE INHIBITION; CONTROLLED STUDY; CRYSTALLOGRAPHY; DRUG CYTOTOXICITY; DRUG SYNTHESIS; HUMAN; IC 50; IN VITRO STUDY; LUNG CARCINOMA; MOLECULAR DYNAMICS; NERVE DEGENERATION; NONHUMAN; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL CULTURE;

ACETYLCHOLINESTERASE; AMIDES; ANTINEOPLASTIC AGENTS; BUTYRYLCHOLINESTERASE; CELL PROLIFERATION; CHOLINESTERASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84897073384     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.03.015     Document Type: Article

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