The role of hyaluronan in wound healing

International Wound Journal

Volumn 11, Issue 2, 2014, Pages 159-163

  Frenkel, Joseph S ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Clinical application; Dermatology; Hyaluronan; Wound dressings; Wound healing

Indexed keywords

HYALURONIC ACID; IMMUNOLOGICAL ADJUVANT;

ARTICLE; HUMAN; INFLAMMATION; KERATINOCYTE; NONHUMAN; PRIORITY JOURNAL; SKIN CELL; SKIN FIBROBLAST; WOUND DRESSING; WOUND HEALING; WOUND HEALING IMPAIRMENT; CHEMISTRY; CYTOLOGY; DERMIS; EPIDERMIS; EPITHELIZATION; GRANULATION TISSUE; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADJUVANTS, IMMUNOLOGIC; DERMIS; EPIDERMIS; GRANULATION TISSUE; HUMANS; HYALURONIC ACID; INFLAMMATION; RE-EPITHELIALIZATION; WOUND HEALING;

EID: 84897068843     PISSN: 17424801     EISSN: 1742481X     Source Type: Journal    
DOI: 10.1111/j.1742-481X.2012.01057.x     Document Type: Article

References (41)

1. Broughton G, Janis J, Attinger C. Wound healing: an overview. Plast Reconstr Surg 2006 ; 117: 1e - s.
2. Enoch S, Leaper D. Basic science of wound healing. Surgery 2005 ; 23: 37 - 42.
3. Slavin J. The role of cytokines in wound healing. J Pathol 1996 ; 178: 5 - 10.
4. Fraser JRE, Laurent TC, Laurent UB. Hyaluronan: its nature, distribution, functions and turnover. J Intern Med 1997 ; 242: 27 - 33.
5. Chen J, Abetangelo G. Functions of hyaluronan in wound repair. Wound Repair Regen 1999 ; 7: 79 - 89.
6. David-Raoudi M, Tranchepain F, Deschrevel B, Vincent JC, Bogdanowicz P, Boumedene K, Pujol JP. Differential effects of hyaluronan and its fragments on fibroblasts: relation to wound healing. Wound Repair Regen 2008 ; 16: 274 - 87.
7. Oksala O, Salo T, Tammi R, Kakkien L, Jalkanen M, Inki P, Larjava H. Expression of proteoglycans and hyaluronan during wound healing. J Histochem Cytochem 1995 ; 43: 125 - 35.
8. Borgognoni L, Reali UM, Santucci M. Low-molecular-weight hyaluronic-acid induces angiogenesis and modulation of the cellular infiltrate in primary and secondary healing wounds. Eur J Dermatol 1996 ; 6: 127 - 31.
9. Kaya G, Rodriguez I, Jorcano JL, Vassalli P, Stamenkovic I. Selective suppression of CD44 in keratinocytes of mice bearing an antisense CD44 transgene driven by a tissue-specific promoter disrupts hyaluronate metabolism in the skin and impairs keratinocyte proliferation. Genes Dev 1997 ; 15: 996 - 1007.
10. Tammi MI, Day AJ, Turley EA. Hyaluronan and homeostasis: a balancing act. J Biol Chem 2001 ; 277: 4581 - 4.
11. Stern R, Asari AA, Sugahara KN. Hyaluronan fragments: an information-rich system. Eur J Cell Biol 2006 ; 85: 699 - 715.
12. Toole BP. Hyaluronan: from extracellular glue to pericellular cue. Nat Rev Cancer 2004 ; 4: 528 - 39.
13. Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P. Molecular Biology Of The Cell. Part V: Cells in their social context: Cell junctions, Cell Adhesion and the Extracellular Matrix 5 ed., 2008 ; pp. 1131 - 1204.
14. Stern R, Maibach HI. Hyaluronan in skin: aspects of aging and its pharmacologic modulation. Clin Dermatol 2008 ; 26: 106 - 122.
15. Moseley R, Walker M, Waddington RJ, Chen WYJ. Comparison of the antioxidant properties of wound dressing materials - carboxymethylcellulose, hyaluronan benzyl ester and hyaluronan, towards polymorphonuclear leukocyte-derived reactive oxygen species. Biomaterials 2003 ; 24: 1549 - 57.
16. Jiang D, Liang J, Nobel PW. Hyaluronan in tissue injury and repair. Ann Rev Cell Dev Biol 2007 ; 23: 435 - 61.
17. Gerdin B, Hällgren R. Dynamic role of hyaluronan in connective tissue activation and inflammation. J Intern Med 1997 ; 242: 49 - 55.
18. Hart J. Inflammation 1: its role in the healing of acute wounds. J Wound Care 2002 11: 205 - 9.
19. Halloran CM, Slavin J. Pathophysiology of wound healing. Surgery 2002 ; 20: i - v.
20. Milner CM, Day AJ. TSG-6: a multifunctional protein associated with inflammation. J Cell Sci 2003 ; 116: 1863 - 73.
21. Wisniewski HG, Vilček J. TSG-6: an IL-1/TNF-inducible protein with anti-inflammatory activity. Cytokine Growth Factor Rev 1997 ; 8: 143 - 156.
22. Fries E, Kaczmarczyk A. Inter-α-inhibitor, hyaluronan and inflammation. Acta Biochim Pol 2003 ; 50: 735 - 42.
23. Noble PN, Jiang D, Liang J. Hyaluronan as an immune regulator in human diseases. Physiol Rev 2011 ; 91: 221 - 64.
24. Wisniewski HG, Hua JC, Poppers DM, Naime D, Vilcek J, Cronstein BN. TNF/IL-1 -inducible protein TSG-6 potentiates plasmin inhibition by inter-α-inhibitor and exerts a strong anti-inflammatory effect in vivo. J Immunol 1996 ; 156: 1609 - 15.
25. Moore K. Cell biology of chronic wounds: the role of inflammation. J Wound Care 1999 ; 8: 345 - 48.
26. Ferguson EL, Roberts JL, Moseley R, Griffiths PC, Thomas DW. Evaluation of the physical and biological properties of hyaluronan and hyaluronan fragments. Int J Pharm 2011 ; 420: 84 - 92.
27. Singer AJ, Clark RAF. Cutaneous wound healing. New Engl J Med 1999 ; 341: 738 - 46.
28. Pardue EL. Role of hyaluronan in angiogenesis and its utility to angiogenic tissue engineering. Organogenesis 2008 ; 4: 203 - 14.
29. Qin Y. The characterisation of alginate wound dressings with different fibre and textile structures. J Appl Polym Sci 2006 ; 100: 2516 - 20.
30. Juhlin L. Hyaluronan in skin. J Intern Med 1997 ; 242: 61 - 66.
31. Venus M, Waterman J, McNab I. Basic physiology of the skin. Surgery 2010 ; 28: 469 - 72.
32. Meyer LJM, Stern R. Age-dependant changes of hyaluronan in human skin. J Invest Dermatol 1994 ; 102: 385 - 9.
33. Iocono JA, Ehrlich HP, Keefer KA, Krummel TM. Hyaluronan induces scarless repair in mouse limb organ culture. J Paediatr Surg 1998 ; 33: 564 - 7.
34. Longaker MT, Chiu ES, Adzick NS, Stern M, Harrision MR, Stern R. Studies of foetal wound healing. Ann Surg 1990 ; 213: 292 - 6.
35. Kutting KF. Wound healing through synergy of hyaluronan and iodine complex. J Wound Care 2011 ; 20: 424 - 30.
36. Dereure O, Czubek M, Combemale P. Efficacy and safety of hyaluronic acid in treatment of leg ulcers: a double-blind RCT. J Wound Care 2012 ; 21: 131 - 9.
37. Brenes R, Ajemian MS, Macaron SH, Panait L, Dudrick SJ. Initial experience using hyaluronate-iodine complex for wound healing. Am Surg 2011 ; 77: s355 - 9.
38. Sobotka L, Smahelova A, Pastarova J, Kusalova M. A case report of the treatment of diabetic foot ulcers using a sodium hyaluronate and iodine complex. Int J Low Extrem Wounds 2007 ; 6: 143 - 7.
39. Wild T, Ponweise D, Rahbarina A, Bruckner M, Czala K, Eberlein T. New galenic antiseptic substance containing iodine (KI3 complex) and hyaluronic acid for treatment of chronic, hardly healing wounds. J Wound Technol 2010 ; 7: 63 - 65.
40. Moseley R, Waddington RJ, Embery G. Hyaluronan and its potential role in periodontal healing. Dent Update 2002 ; 29: 144 - 8.
41. Dorsett-Martin W. Rat models of skin wound healing: a review. Wound Repair Regen 2004 ; 12: 591 - 9.