Efficacy and safety of hyaluronic acid in treatment of leg ulcers: A double-blind RCT

Journal of Wound Care

Volumn 21, Issue 3, 2012, Pages 131-139

  Dereure, O ^a   Czubek, M ^b   Combemale, P ^c  

^a HÔPITAL SAINT ELOI   (France)

^b NICOLAUS COPERNICUS UNIVERSITY   (Poland)

^c HIA Desgenettes   (France)

Author keywords

Double blind RC T; Efficacy; Hyaluronic acid; Leg ulcer; Reduction of pain; Reduction of wound size; Safety

Indexed keywords

HYALURONIC ACID; IMMUNOLOGICAL ADJUVANT;

AGED; ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; GRANULATION TISSUE; HUMAN; INTENTION TO TREAT ANALYSIS; LEG ULCER; MALE; MIDDLE AGED; MULTICENTER STUDY; PAIN ASSESSMENT; PATHOLOGY; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; WOUND HEALING;

ADJUVANTS, IMMUNOLOGIC; AGED; AGED, 80 AND OVER; DOUBLE-BLIND METHOD; FEMALE; GRANULATION TISSUE; HUMANS; HYALURONIC ACID; INTENTION TO TREAT ANALYSIS; LEG ULCER; MALE; MIDDLE AGED; PAIN MEASUREMENT; TREATMENT OUTCOME; WOUND HEALING;

EID: 84861692235     PISSN: 09690700     EISSN: None     Source Type: Journal    
DOI: 10.12968/jowc.2012.21.3.131     Document Type: Article

References (23)

1. Nelson, E.A. Compression therapy, dressings and topical agents for venous ulcer healing. Phlebology. 2010; 25: (Suppl. 1), 28-34.
2. Palfreyman, S., Nelson, E.A., Michaels, J.A. Dressings for venous leg ulcers: Systematic review and meta-Analysis. BMJ. 2007; 335: 7613, 244.
3. Phillips, T.J., Machado, F., Trout, R. et al. Prognostic indicators in venous ulcers. J Am Acad Dermatol. 2000; 43: 4, 627-630.
4. Chen, W.Y., Abatangelo, G. Functions of hyaluronan in wound repair. Wound Repair Regen. 1999; 7: 2, 79-89. (Pubitemid 29200045)
5. Brown, J.A. The role of hyaluronic acid in wound healing's proliferative phase. J Wound Care. 2004; 13: 2, 48-51.
6. Anderson, I. The properties of hyaluronan and its role in wound healing. Prof Nurse. 2001; 17: 4, 232-235.
7. Laurent, T.C., Fraser, J.R. Hyaluronan. FASEB J. 1992; 6: 7, 2397-2404.
8. Abatangelo, G., Martelli, M., Vecchia, P. Healing of hyaluronic acid-enriched wounds: Histological observations. J Surg Res. 1983; 35: 5, 410-416. (Pubitemid 14234317)
9. Lees, V.C., Fan, T.P., West, D.C. Angiogenesis in a delayed revascularization model is accelerated by angiogenic oligosaccharides of hyaluronan. Lab Invest. 1995; 73: 2, 259-266.
10. King, S.R., Hickerson, W.L., Proctor, K.G. Beneficial actions of exogenous hyaluronic acid on wound healing. Surgery. 1991; 109: 1, 76-84.
11. Liguori, V., Guillemin, C., Pesce, G.F. et al. Doubleblind, randomized clinical study comparing hyaluronic acid cream to placebo in patients treated with radiotherapy. Radiother Oncol. 1997; 42: 2, 155-161. (Pubitemid 27132744)
12. Barrois, B., Carles, M., Rumeau, M. et al. Efficacy and tolerability of hyaluronan (ialuset) in the treatment of pressure ulcers: A multicentre, non-randomised, pilot study. Drugs R D. 2007; 8: 5, 267-273. (Pubitemid 47403122)
13. Meaume, S., Ourabah, Z., Romanelli, M. et al. Efficacy and tolerance of a hydrocolloid dressing containing hyaluronic acid for the treatment of leg ulcers of venous or mixed origin. Curr Med Res Opin. 2008; 24: 10, 2729-2739.
14. Abbruzzese, L., Rizzo, L., Fanelli, G. et al. Effectiveness and safety of a novel gel dressing in the management of neuropathic leg ulcers in diabetic patients: A prospective double-blind randomized trial. Int J Low Extrem Wounds. 2009; 8: 3, 134-140.
15. Ortonne, J.P. A controlled study of the activity of hyaluronic acid in the treatment of venous leg ulcers. J Dermatol Treat. 1996; 7: 75-81. (Pubitemid 26235527)
16. Galasso, U., Fiumano, F., Cloro, L., Strati, V. Use of hyaluronic acid in the therapy of varicose ulcers of the lower limbs [in Italian]. Minerva Chir. 1978; 33: 21, 1581-1596. (Pubitemid 9073772)
17. Weindl, G., Schaller, M., Schafer-Korting, M., Korting, H.C. Hyaluronic acid in the treatment and prevention of skin diseases: Molecular biological, pharmaceutical and clinical aspects. Skin Pharmacol Physiol. 2004; 17: 5, 207-213. (Pubitemid 39370251)
18. EC EaID. General Guidelines on Medical Devices. Clinical Evaluation: A guide for manufacturers and notified bodies. Report No.: MEDDEV 2.7.1, 2003.
19. HAS/Guidelines Department. Managing Venous Leg Ulcers (Excluding Dressings) [in French]. HAS, 2006.
20. Mehlisch, D.R., Aspley, S., Daniels, S.E., Bandy, D.P. Comparison of the analgesic efficacy of concurrent ibuprofen and paracetamol with ibuprofen or paracetamol alone in the management of moderate to severe acute postoperative dental pain in adolescents and adults: A randomized, double-blind, placebocontrolled, parallel-group, single-dose, two-center, modified factorial study. Clin Ther. 2010; 32: 5, 882-895.
21. Kirby, A., Gebski, V., Keech, A.C. Determining the sample size in a clinical trial. Med J Aust. 2002; 177: 5, 256-257.
22. Papazoglou, E.S., Zubkov, L., Mao, X. et al. Image analysis of chronic wounds for determining the surface area. Wound Repair Regen. 2010; 18: 4, 349-358.
23. Gelfand, J.M., Hoffstad, O., Margolis, D.J. Surrogate endpoints for the treatment of venous leg ulcers. J Invest Dermatol. 2002; 119: 6, 1420-1424.