Characterization of chemically modified oligonucleotides targeting a pathogenic mutation in human mitochondrial DNA

Biochimie

Volumn 100, Issue 1, 2014, Pages 192-199

  Tonin, Yann ^a   Heckel, Anne Marie ^a   Dovydenko, Ilya ^a,b   Meschaninova, Mariya ^b   Comte, Caroline ^a   Venyaminova, Alya ^b   Pyshnyi, Dmitrii ^b   Tarassov, Ivan ^a   Entelis, Nina ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b INSTITUTE OF CHEMICAL BIOLOGY AND FUNDAMENTAL MEDICINE   (Russian Federation)

Author keywords

Cybrid cells; Mitochondria; Modified oligonucleotides; mtDNA heteroplasmy; RNA import

Indexed keywords

MITOCHONDRIAL DNA; NUCLEASE; OLIGONUCLEOTIDE; RIBOSE; RNA; THYMIDINE;

ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; CYBRID; DNA HYBRIDIZATION; GENE DELETION; GENE MUTATION; HETEROPLASMY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; LIFESPAN; METHYLATION; MITOCHONDRION; MOLECULE; MUTANT; PATHOGENESIS; RNA STABILITY; WILD TYPE;

CYBRID CELLS; MITOCHONDRIA; MODIFIED OLIGONUCLEOTIDES; MTDNA HETEROPLASMY; RNA IMPORT;

CELLS, CULTURED; CHIMERA; DNA, MITOCHONDRIAL; GENE EXPRESSION REGULATION; GENETIC HETEROGENEITY; GENETIC VECTORS; GENOTYPE; HUMANS; INHERITANCE PATTERNS; MITOCHONDRIA; MITOCHONDRIAL DISEASES; MITOSIS; MOLECULAR TARGETED THERAPY; MUTATION; OLIGORIBONUCLEOTIDES; PHENOTYPE;

EID: 84897068609     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2013.08.020     Document Type: Article

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