The role of aryl hydrocarbon receptor (AHR) and ahr-interacting protein (AIP) in the pathogenesis of pituitary adenomas

Tumors of the Central Nervous System: Pineal, Pituitary, and Spinal Tumors

Volumn 10, Issue , 2013, Pages 189-201

  Jaffrain Rea, Marie Lise ^a   Beckers, Albert ^b  

^a UNIVERSITY OF L'AQUILA   (Italy)

^b UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84897057239     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-94-007-5681-6_21     Document Type: Chapter

References (36)

1. Asa SL, Ezzat S (2009) The pathogenesis of pituitary tumors. Ann Rev Pathol 4:97-126
2. Barhoover MA, Hall JM, Greenlee WF, Thomas RS (2010) Aryl hydrocarbon receptor regulates cell cycle progression in human breast cancer cells via a functional interaction with cyclin-dependent kinase 4. Mol Pharmacol 77:195-201
3. Beckers A (2010) Higher prevalence of clinically relevant pituitary adenomas confirmed. Clin Endocrinol (Oxf) 72:290-291
4. Beischlag TV, Morales JL, Hollingshead BD, Perdew GH (2008) The aryl hydrocarbon receptor complex and the control of gene expression. Crit Rev Eukaryot Gene Expr 18:207-250
5. Boikos SA, Stratakis CA (2007) Molecular genetics of the cAMP-dependent protein kinase pathway and of sporadic pituitary tumorigenesis. Hum Mol Genet 16(Spec No 1):R80-R87
6. Cakir M, Grossman AB (2009) Targeting MAPK (Ras/ERK) and PI3K/Akt pathways in pituitary tumorigenesis. Expert Opin Ther Targets 13:1121-1134
7. Canibano C, Rodriguez NL, Saez C, Tovar S, Garcia-Lavandeira M, Borrello MG, Vidal A, Costantini F, Japon M, Dieguez C, Alvarez CV (2007) The dependence receptor Ret induces apoptosis in somatotrophs through a Pit-1/p53 pathway, preventing tumor growth. EMBO J 26:2015-2028
8. Caronti B, Paladini G, Caldelaro C, Bevilacqua MG, Petrangeli E, Esposito V, Tamburrano G, Gulino A, Jaffrain-Rea ML (1995) Effects of gonadal steroids on the growth of human pituitary adenomas in vitro. Tumor Biol 16:353-364
9. Carver LA, La Pres JJ, Jain S, Dunham EE, Bradfield CA (1998) Characterization of the Ah receptor - associated protein ARA9. J Biol Chem 50:33580-33587
10. Daly AF, Jaffrain-Rea ML, Ciccarelli A, Valdes-Socin H, Rohmer V, Tamburrano G, Borson-Chazot C, Estour B, Ciccarelli E, Brue T, Ferolla P, Emy P, Colao A, De Menis E, Lecomte P, Penfornis F, Delemer B, Bertherat J, Wemeau JL, De Herder W, Archambeaud F, Stevenaert A, Calender A, Murat A, Cavagnini F, Beckers A (2006) Clinical characterization of familial isolated pituitary adenomas. J Clin Endocrinol Metab 91:3316-3323
11. Daly AF, Vanbellinghen JF, Khoo SK, Jaffrain-Rea ML, Naves LA, Guitelman MA, Murat A, Emy P, Gimenez-Roqueplo AP, Tamburrano G, Raverot G, Barlier A, De Herder W, Penfornis A, Ciccarelli E, Estour B, Lecomte P, Gatta B, Chabre O, Sabate MI, Bertagna X, Garcia Basavilbaso N, Stalldecker G, Colao A, Ferolla P, Wemeau JL, Caron P, Sadoul JL, Oneto A, Archambeaud F, Calender A, Sinilnikova O, Montanana CF, Cavagnini F, Hana V, Solano A, Delettieres D, Luccio-Camelo DC, Basso A, Rohmer V, Brue T, Bours V, Teh BT, Beckers A (2007) Aryl hydrocarbon receptor-interacting protein gene mutations in familial isolated pituitary adenomas: analysis in 73 families. J Clin Endocrinol Metab 92:1891-1896
12. Daly AF, Tichomirowa MA, Petrossians P, Heliovaara E, Jaffrain-Rea ML, Barlier A, Naves LA, Ebeling T, Karhu A, Raappana A, Cazabat L, De Menis E, Montanana CF, Raverot G, Weil RJ, Sane T, Maiter D, Neggers S, Yaneva M, Tabarin A, Verrua E, Eloranta E, Murat A, Vierimaa O, Salmela PI, Emy P, Toledo RA, Sabaté MI, Villa C, Popelier M, Salvatori R, Jennings J, Longás AF, Labarta Aizpún JI, Georgitsi M, Paschke R, Ronchi C, Valimaki M, Saloranta C, De Herder W, Cozzi R, Guitelman M, Magri F, Lagonigro MS, Halaby G, Corman V, Hagelstein MT, Vanbellinghen JF, Barra GB, Gimenez-Roqueplo AP, Cameron FJ, Borson-Chazot F, Holdaway I, Toledo SP, Stalla GK, Spada A, Zacharieva S, Bertherat J, Brue T, Bours V, Chanson P, Aaltonen LA, Beckers A (2010) Clinical characteristics and therapeutic responses in patients with germ-line AIP mutations and pituitary adenomas: an international collaborative study. J Clin Endocrinol Metab 95:E373-E383
13. De Oüveira SK, Smolenski A (2009) Phosphodiesterases Link the aryl hydrocarbon receptor complex to cyclic nucleotide signaling. Biochem Pharmacol 77:723-733
14. Elango A, Shepherd B, Chen TT (2006) Effects of endocrine disrupters on the expression of growth hormone and prolactin mRNA in the rainbow trout pituitary. Gen Comp Endocrinol 145:116-127
15. Galdelha MR, Prezant TR, Une KR, Glick RP, Moskal Ii SF, Vaisman M, Melmed S, Kineman RD, Frohman LA (1999) Loss of heterozygosity on chromosome 11q13 in two families with acromegaly/gigantism is independent of mutations of the multiple endocrine neoplasia type I gene. J Clin Endocrinol Metab 84:249-256
16. Heliovaara E, Raitila A, Launonen V, Paetau A, Arola J, Lehtonen H, Sane T, Weil RJ, Vierimaa O, Salmela P, Tuppurainen K, Makinen M, Aaltonen LA, Karhu A (2009) The expression of AIP-related molecules in elucidation of cellular pathways in pituitary adenomas. Am J Pathol 175:2501-2507
17. Henklovà P, Vrzal R, Ulrichovà J, Dvorak Z (2008) Role of mitogen-activated protein kinases in aryl hydrocarbon signaling. Chem Biol Interact 172:93-104
18. Igreja S, Chahal HS, King P, Bolger GB, Srirangalingam U, Guasti L, Chapple JP, Trivellin G, Gueorguiev M, Guegan K, Stals K, Khoo B, Kumar AV, Ellard S, Grossman AB, Korbonits M, International FIPA Consortium (2010) Characterization of aryl hydrocarbon receptor interacting protein (AIP) mutations in familial isolated pituitary adenoma families. Hum Mut 31:950-960
19. Jaffrain-Rea ML, Petrangeli E, Ortolani F, Fraioli B, Lise A, Esposito V, Spagnoli LG, Tamburrano G, Frati L, Gulino A (1996) Cellular receptors for sex steroids in human pituitary adenomas. J Endocrinol 151:175-184
20. Jaffrain-Rea ML, Angelini M, Gargano D, Tichomirowa MA, Daly AF, Vanbellinghen JF, D’Innocenzo E, Barlier A, Giangaspero F, Esposito V, Ventura L, Arcella A, Theodoropoulou M, Naves LA, Fajardo C, Zacharieva S, Rohmer V, Brue T, Gulino A, Cantore G, Alesse E, Beckers A (2009) Expression of aryl hydrocarbon receptor (AHR) and AHR-interacting protein in pituitary adenomas: pathological and clinical implications. Endocr Relat Cancer 16:1029-1043
21. Jaffrain-Rea ML, Daly AF, Angelini M, Petrossians P, Bours V, Beckers A (2010a) Genetic susceptibility in pituitary adenomas: from pathogenesis to clinical implications. Exp Rev Endocrinol Metab 6(2):195-214
22. Jaffrain-Rea ML, Angelini M, Tichomirowa MA, Theodoropoulou M, Daly AF, Barlier A, Naves LA, Fajardo C, Zacharieva S, Rohmer V, Brue T, Ventura L, Esposito V, Giangaspero F, Alesse E, Beckers A (2010 b). Factors associated with AIP expression in somatotropinomas and the possible influence of somatostatin analogues. 15th Congress of the European Neuroendocrine Association, Liège, 22-25 September 2010, Belgium.
23. Japón MA, Urbano AG, Sáez C, Segura DI, Cerro AL, Diéguez C, Alvarez C (2002) Glial-derived neurotropic factor and RET gene expression in normal human anterior pituitary cell types and in pituitary tumors. J Clin Endocrinol Metab 87:1879-1884
24. Laenger A, Lang-Rollin I, Kozany C, Zschocke J, Zimmermann N, Rüegg J, Holsboer F, Hausch F, Rein T (2009) XAP2 inhibits glucocorticoid activity in mammalian cells. FEBS Let 583:1493-1498
25. Leontiou CA, Gueorguiev M, van der Spuy J, Quinton R, Lolli F, Hassan S, Chahal HS, Igreja SC, Jordan S, Rowe J, Stolbrink M, Christian HC, Wray J, Bishop-Bailey D, Berney DM, Wass JA, Popovic V, Ribeiro-Oliveira A Jr, Gadelha MR, Monson JP, Akker SA, Davis JR, Clayton RN, Yoshimoto K, Iwata T, Matsuno A, Eguchi K, Musat M, Flanagan D, Peters G, Bolger GB, Chapple JP, Frohman LA, Grossman AB, Korbonits M (2008) The role of the aryl hydrocarbon receptor-interacting protein gene in familial and sporadic pituitary adenomas. J Clin Endocrinol Metab 93:2390-2401
26. Lin BC, Sullivan R, Lee Y, Moran S, Glover E, Bradfield CA (2007) Deletion of the aryl hydrocarbon receptor-associated protein 9 leads to cardiac malformation and embryonic lethality. J Biol Chem 282:35924-35932
27. Marlowe JL, Puga A (2005) Aryl hydrocarbon receptor, cell cycle regulation, toxicity, and tumorigenesis. J Cell Biochem 96:1174-1184
28. Ozfirat Z, Korbonits M (2010) AIP gene and familial isolated pituitary adenomas. Mol Cell Endocrinol 326:71-79
29. Puga A, Ma C, Marlowe JL (2009) The aryl hydrocarbon receptor cross-talks with multiple signal transduction pathways. Biochem Pharmacol 77:713-722
30. Raitila A, Lehtonen HJ, Arola J, Heliovaara E, Ahlsten M, Georgitsi M, Jalanko A, Paetau A, Aaltonen LA, Karhu A (2010) Mice with inactivation of aryl hydrocarbon receptor-interacting protein (Aip) display complete penetrance of pituitary adenomas with aberrant ARNT expression. Am J Pathol 177:1969-1976
31. Sumanasekera WK, Tien ES, Turpey R, Van den Heuvel JP, Perdew GH (2003) Evidence that peroxisome proliferator-activated receptor alpha is complexed with the 90-kDa heat shock protein and the hepatitis virus B X-associated protein 2. J Biol Chem 278:4467-4473
32. Thakker RV (2010) Multiple endocrine neoplasia type 1 (MEN1). Best Pract Res Clin Endocrinol Metab 24:355-370
33. Toledo RA, Mendonca BB, Fragoso MC, Soares IC, Almeida MQ, Moraes MB, Lourenço-Jr DM, Alves VA, Bronstein MD, Toledo SP (2010) Isolated familial somatotropinoma: 11q13-OH and gene/proteinexpression analysis suggests a possible involvement of AIP also in non-pituitary tumorigenesis. Clinics (Sao Paulo) 65:407-415
34. Tolon RM, Castillo AI, Aranda A (1998) Activation of the prolactin gene by peroxisome proliferator-activated receptor a appears to be DNA binding-independent. J Biol Chem 41:26652-26661
35. Vargiolu M, Fusco D, Kurelac I, Dirnberger D, Baumeister R, Morra I, Melcarne A, Rimondini R, Romeo G, Bonora E (2009) The tyrosine kinase receptor RET interacts in vivo with aryl hydrocarbon receptor-interacting protein to alter survivin availability. J Clin Endocrinol Metab 94:2571-2578
36. Vierimaa O, Georgitsi M, Lehtonen R, Vahteristo P, Kokko A, Raitila A, Tuppurainen K, Ebeling TM, Salmela PI, Paschke R, Gundogdu S, De Menis E, Makinen MJ, Launonen V, Karhu A, Aaltonen LA (2006) Pituitary adenoma predisposition caused by germline mutations in the AIP gene. Science 312:1228-1230