Activated pregnane X receptor inhibits cervical cancer cell proliferation and tumorigenicity by inducing G2/M cell-cycle arrest

Cancer Letters

Volumn 347, Issue 1, 2014, Pages 88-97

  Niu, Yongdong ^a   Wang, Ziliang ^b   Huang, Haihua ^c   Zhong, Shuping ^d   Cai, Wenfeng ^a   Xie, Yangmin ^a   Shi, Ganggang ^a  

^a SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

^b FUDAN UNIVERSITY SHANGHAI CANCER CENTER   (China)

^c THE SECOND AFFILIATED HOSPITAL OF SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Cell cycle; Cervical cancer; Pregnane X receptor; Proliferation; Tumorigenicity

Indexed keywords

ANAPHASE PROMOTING COMPLEX SUBUNIT 2; CELL PROTEIN; CULLIN; CULLIN 1; CULLIN 2; CULLIN 3; CYCLIN DEPENDENT KINASE INHIBITOR 1A; PREGNANE X RECEPTOR; PROTEIN MAD2L1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CARCINOGENICITY; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MITOSIS INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT; UTERINE CERVIX CANCER;

MUS MUSCULUS;

CELL CYCLE; CERVICAL CANCER; PREGNANE X RECEPTOR; PROLIFERATION; TUMORIGENICITY;

ANIMALS; CELL DIVISION; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; G2 PHASE; HETEROGRAFTS; HUMANS; MICE; MICE, INBRED BALB C; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, STEROID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; UTERINE CERVICAL NEOPLASMS;

EID: 84897045947     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2014.01.026     Document Type: Article

References (24)

1. Munoz N., Bosch F.X., de Sanjose S., Herrero R., Castellsague X., Shah K.V., Snijders P.J., Meijer C.J. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N. Engl. J. Med. 2003, 348:518-527.
2. Steinbrook R. The potential of human papillomavirus vaccines. N. Engl. J. Med. 2006, 354:1109-1112.
3. zur Hausen H. Papillomaviruses and cancer: from basic studies to clinical application. Nat. Rev. Cancer 2002, 2:342-350.
4. Tjalma W.A., Fiander A., Reich O., Powell N., Nowakowski A.M., Kirschner B., Koiss R., O'Leary J., Joura E.A., Rosenlund M., Colau B., Schledermann D., Kukk K., Damaskou V., Repanti M., Vladareanu R., Kolomiets L., Savicheva A., Shipitsyna E., Ordi J., Molijn A., Quint W., Raillard A., Rosillon D., De Souza S.C., Jenkins D., Holl K., Grp H.S.S. Differences in human papillomavirus type distribution in high-grade cervical intraepithelial neoplasia and invasive cervical cancer in Europe. Int. J. Cancer 2013, 132:854-867.
5. Smith J.S., Green J., Berrington de Gonzalez A., Appleby P., Peto J., Plummer M., Franceschi S., Beral V. Cervical cancer and use of hormonal contraceptives: a systematic review. Lancet 2003, 361:1159-1167.
6. Ouyang N., Ke S., Eagleton N., Xie Y., Chen G., Laffins B., Yao H., Zhou B., Tian Y. Pregnane X receptor suppresses proliferation and tumourigenicity of colon cancer cells. Br. J. Cancer 2010, 102:1753-1761.
7. Gupta D., Venkatesh M., Wang H., Kim S., Sinz M., Goldberg G.L., Whitney K., Longley C., Mani S. Expanding the roles for pregnane X receptor in cancer: proliferation and drug resistance in ovarian cancer. Clin. Cancer Res. 2008, 14:5332-5340.
8. Wang H., Venkatesh M., Li H., Goetz R., Mukherjee S., Biswas A., Zhu L., Kaubisch A., Wang L., Pullman J., Whitney K., Kuro-o M., Roig A.I., Shay J.W., Mohammadi M., Mani S. Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice. J. Clin. Invest. 2011, 121:3220-3232.
9. Dai G., He L., Bu P., Wan Y.J. Pregnane X receptor is essential for normal progression of liver regeneration. Hepatology 2008, 47:1277-1287.
10. Masuyama H., Hiramatsu Y., Kodama J., Kudo T. Expression and potential roles of pregnane X receptor in endometrial cancer. J. Clin. Endocrinol. Metab. 2003, 88:4446-4454.
11. Masuyama H., Nakatsukasa H., Takamoto N., Hiramatsu Y. Down-regulation of pregnane X receptor contributes to cell growth inhibition and apoptosis by anticancer agents in endometrial cancer cells. Mol. Pharmacol. 2007, 72:1045-1053.
12. Chen Y., Tang Y., Guo C., Wang J., Boral D., Nie D. Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters. Biochem. Pharmacol. 2012, 83:1112-1126.
13. Xie W., Barwick J.L., Downes M., Blumberg B., Simon C.M., Nelson M.C., Neuschwander-Tetri B.A., Brunt E.M., Guzelian P.S., Evans R.M. Humanized xenobiotic response in mice expressing nuclear receptor SXR. Nature 2000, 406:435-439.
14. Xie W., Radominska-Pandya A., Shi Y., Simon C.M., Nelson M.C., Ong E.S., Waxman D.J., Evans R.M. An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids. Proc. Natl. Acad. Sci. USA 2001, 98:3375-3380.
15. Niu Y., Wu Z., Shen Q., Song J., Luo Q., You H., Shi G., Qin W. Hepatitis B virus X protein co-activates pregnane X receptor to induce the cytochrome P450 3A4 enzyme, a potential implication in hepatocarcinogenesis. Dig. Liver Dis. 2013, 45:1041-1048.
16. Fan S., Niu Y., Tan N., Wu Z., Wang Y., You H., Ke R., Song J., Shen Q., Wang W., Yao G., Shu H., Lin H., Yao M., Zhang Z., Gu J., Qin W. LASS2 enhances chemosensitivity of breast cancer by counteracting acidic tumor microenvironment through inhibiting activity of V-ATPase proton pump. Oncogene 2013, 32:1682-1690.
17. Zhou J., Liu M., Zhai Y., Xie W. The antiapoptotic role of pregnane X receptor in human colon cancer cells. Mol. Endocrinol. 2008, 22:868-880.
18. Dotzlaw H., Leygue E., Watson P., Murphy L.C. The human orphan receptor PXR messenger RNA is expressed in both normal and neoplastic breast tissue. Clin. Cancer Res. 1999, 5:2103-2107.
19. Hausen H. Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis. J. Natl. Cancer Inst. 2000, 92:690-698.
20. Dubrac S., Elentner A., Ebner S., Horejs-Hoeck J., Schmuth M. Modulation of T lymphocyte function by the pregnane X receptor. J. Immunol. 2010, 184:2949-2957.
21. Masuyama H., Suwaki N., Tateishi Y., Nakatsukasa H., Segawa T., Hiramatsu Y. The pregnane X receptor regulates gene expression in a ligand- and promoter-selective fashion. Mol. Endocrinol. 2005, 19:1170-1180.
22. Reed S.I. Ratchets and clocks: the cell cycle, ubiquitylation and protein turnover. Nat. Rev. Mol. Cell Biol. 2003, 4:855-864.
23. Yang M.J., Li B., Tomchick D.R., Machius M., Rizo J., Yu H.T., Luo X.L. P31(comet) blocks Mad2 activation through structural mimicry. Cell 2007, 131:744-755.
24. Heilman D.W., Green M.R., Teodoro J.G. The anaphase promoting complex: a critical target for viral proteins and anti-cancer drugs. Cell Cycle 2005, 4:560-563.