μ-Opioid receptor inhibition of substance P release from primary afferents disappears in neuropathic pain but not inflammatory pain

Neuroscience

Volumn 267, Issue , 2014, Pages 67-82

  Chen, W ^a,b   McRoberts, J A ^a,b   Marvizon J C G ^a,b  

^a VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Inflammation; Internalization; Neurokinin 1 receptor; Neuropathic pain; Opioid receptor; Substance p

Indexed keywords

ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; FREUND ADJUVANT; MU OPIATE RECEPTOR; NEUROKININ 1 RECEPTOR; PLACEBO; SUBSTANCE P; NARCOTIC ANALGESIC AGENT;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC CONSTRICTION INJURY; CONTROLLED STUDY; DORSAL ROOT POTENTIAL; EVOKED RESPONSE; INFLAMMATION; INFLAMMATORY PAIN; INTERNALIZATION; MALE; NERVE STIMULATION; NEUROPATHIC PAIN; NEUROTRANSMITTER RELEASE; NOCICEPTIVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; RECEPTOR DOWN REGULATION; SCIATIC NERVE; SENSORY NERVE; SENSORY NERVE CELL; SHAM PROCEDURE; SIGNAL DETECTION; SPINAL CORD DORSAL HORN; SPINAL GANGLION; ANIMAL; CHEMICALLY INDUCED; COMPLICATION; CYTOLOGY; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; HYPERALGESIA; METABOLISM; NERVE CELL; PAIN; PATHOLOGY; SCIATICA; SPINAL CORD; SPRAGUE DAWLEY RAT;

ANALGESICS, OPIOID; ANIMALS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; GANGLIA, SPINAL; HYPERALGESIA; INFLAMMATION; MALE; NEURONS; PAIN; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NEUROKININ-1; RECEPTORS, OPIOID, MU; SCIATIC NERVE; SCIATICA; SPINAL CORD; SUBSTANCE P;

EID: 84897036358     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2014.02.023     Document Type: Article

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