Wikstroelide M potently inhibits HIV replication by targeting reverse transcriptase and integrase nuclear translocation

Chinese Journal of Natural Medicines

Volumn 12, Issue 3, 2014, Pages 186-193

  Zhang, Xuan ^a,c   Huang, Sheng Zhuo ^b   Gu, Wan Gang ^d   Yang, Liu Meng ^a   Chen, Huan ^a   Zheng, Chang Bo ^e   Zhao, You Xing ^b   Wan, David Chi Cheong ^d   Zheng, Yong Tang ^a  

^a KUNMING INSTITUTE OF ZOOLOGY   (China)

^b INSTITUTE OF TROPICAL BIOSCIENCE AND BIOTECHNOLOGY   (China)

^c KUNMING MEDICAL UNIVERSITY   (China)

^d and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

^e CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Daphnane diterpene; Daphne acutiloba rehder; HIV; Integrase; Lens epithelium derived growth factor (LEDGF p75); Molecular docking; Nuclear translocation; Reverse trascriptase; Wikstroelide M

Indexed keywords

ANTIGEN P24; ANTIVIRUS AGENT; DITERPENE; INTEGRASE; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG; WIKSTROELIDE M; ZIDOVUDINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; INTEGRASE INHIBITOR; LENS EPITHELIUM-DERIVED GROWTH FACTOR; P31 INTEGRASE PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; PLANT EXTRACT; REVERSE TRANSCRIPTASE, HUMAN IMMUNODEFICIENCY VIRUS 1; SIGNAL PEPTIDE;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOLYSIS; CYTOPATHOGENIC EFFECT; DAPHNE; DAPHNE ACUTILOBA; DRUG CYTOTOXICITY; DRUG TARGETING; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 (STRAIN 9495); HUMAN IMMUNODEFICIENCY VIRUS 1 (STRAIN A17); HUMAN IMMUNODEFICIENCY VIRUS 1 (STRAIN IIIB); HUMAN IMMUNODEFICIENCY VIRUS 2 (STRAIN CBL 20); HUMAN IMMUNODEFICIENCY VIRUS 2 (STRAIN ROD); MOLECULAR DOCKING; NONHUMAN; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION; VIRUS INHIBITION; VIRUS REPLICATION; VIRUS STRAIN; VIRUS TRANSCRIPTION; ANTAGONISTS AND INHIBITORS; CELL LINE; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; HIV INFECTIONS; HUMAN IMMUNODEFICIENCY VIRUS 2; METABOLISM; PHYTOTHERAPY; VIROLOGY; VIRUS DNA CELL DNA INTERACTION;

ANTI-HIV AGENTS; CELL LINE; DAPHNE; DITERPENES; HIV INFECTIONS; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HIV REVERSE TRANSCRIPTASE; HIV-1; HIV-2; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; PHYTOTHERAPY; PLANT EXTRACTS; VIRUS INTEGRATION; VIRUS REPLICATION;

EID: 84897029826     PISSN: 20956975     EISSN: 18755364     Source Type: Journal    
DOI: 10.1016/S1875-5364(14)60031-5     Document Type: Article

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