Obstructive sleep apnea syndrome is associated with metabolic syndrome and inflammation

European Archives of Oto-Rhino-Laryngology

Volumn 271, Issue 4, 2014, Pages 825-831

  Lin, Qi Chang ^a,b   Chen, Li Da ^a,b   Yu, Yao Hua ^a,b   Liu, Kai Xiong ^a,b   Gao, Shao Yong ^a,b  

^a Fujian Provincial Sleep Disordered Breathing Clinic Center   (China)

^b FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

Cardiovascular risk; High sensitivity C reactive protein; Metabolic syndrome; Obstructive sleep apnea

Indexed keywords

C REACTIVE PROTEIN; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; OXYGEN; TRIACYLGLYCEROL;

ADULT; APNEA HYPOPNEA INDEX; ARTICLE; ASTHMA; BODY HEIGHT; BODY MASS; BODY WEIGHT; CEREBROVASCULAR DISEASE; CHOLESTEROL BLOOD LEVEL; CHRONIC KIDNEY FAILURE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; EPWORTH SLEEPINESS SCALE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERGLYCEMIA; HYPERTENSION; HYPERTRIGLYCERIDEMIA; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; MIDDLE AGED; NECK CIRCUMFERENCE; OBESITY; OXYGEN SATURATION; POLYSOMNOGRAPHY; PRIORITY JOURNAL; SLEEP DISORDERED BREATHING; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE;

ADULT; BLOOD GLUCOSE; BLOOD PRESSURE; BODY MASS INDEX; C-REACTIVE PROTEIN; CHOLESTEROL, HDL; CHOLESTEROL, LDL; COHORT STUDIES; CROSS-SECTIONAL STUDIES; HUMANS; HYPERGLYCEMIA; HYPERLIPIDEMIAS; HYPERTENSION; INFLAMMATION; MALE; METABOLIC SYNDROME X; MIDDLE AGED; OBESITY; OBESITY, ABDOMINAL; POLYSOMNOGRAPHY; RISK FACTORS; SEVERITY OF ILLNESS INDEX; SLEEP APNEA, OBSTRUCTIVE; TRIGLYCERIDES;

EID: 84897021916     PISSN: 09374477     EISSN: 14344726     Source Type: Journal    
DOI: 10.1007/s00405-013-2669-8     Document Type: Article

References (39)

1. Young T, Peppard PE, Gottlieb DJ (2002) Epidemiology of obstructive sleep apnea: a population health perspective. Am J Respir Crit Care Med 165:1217-1239 (Pubitemid 34461732)
2. Shahar E, Whitney CW, Redline S, Lee ET, Newman AB, Nieto FJ, O'Connor GT, Boland LL, Schwartz JE, Samet JM (2001) Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the sleep heart health study. Am J Respir Crit Care Med 163:19-25 (Pubitemid 32095247)
3. Chami HA, Resnick HE, Quan SF, Gottlieb DJ (2011) Association of incident cardiovascular disease with progression of sleep-disordered breathing. Circulation 123:1280-1286
4. Redline S, Yenokyan G, Gottlieb DJ, Shahar E, O'Connor GT, Resnick HE, Diener-West M, Sanders MH, Wolf PA, Geraghty EM, Ali T, Lebowitz M, Punjabi NM (2010) Obstructive sleep apnea-hypopnea and incident stroke: the sleep heart health study. Am J Respir Crit Care Med 182:269-277
5. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC Jr, Spertus JA, Costa F (2005) Diagnosis and management of the metabolic syndrome: an American heart association/national heart, lung, and blood institute scientific statement. Circulation 112:2735-2752 (Pubitemid 41532612)
6. Reaven GM (1988) Banting lecture 1988: role of insulin resistance in human disease. Diabetes 37:1595-1607
7. Lakka HM, Laaksonen DE, Lakka TA, Niskanen LK, Kumpusalo E, Tuomilehto J, Salonen JT (2002) The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA 288:2709-2716 (Pubitemid 35403784)
8. Ho JS, Cannaday JJ, Barlow CE, Mitchell TL, Cooper KH, FitzGerald SJ (2008) Relation of the number of metabolic syndrome risk factors with all-cause and cardiovascular mortality. Am J Cardiol 102:689-692
9. Thomas GN, Phillips AC, Carroll D, Gale CR, Batty GD (2010) The metabolic syndrome adds utility to the prediction of mortality over its components: the Vietnam experience study. Atherosclerosis 210:256-261
10. Corrado E, Rizzo M, Coppola G, Fattouch K, Novo G, Marturana I, Ferrara F, Novo S (2010) An update on the role of markers of inflammation in atherosclerosis. J Atheroscler Thromb 17:1-11
11. Ikonomidis I, Stamatelopoulos K, Lekakis J, Vamvakou GD, Kremastinos DT (2008) Inflammatory and non-invasive vascular markers: the multimarker approach for risk stratification in coronary artery disease. Atherosclerosis 199:3-11
12. Libby P (2002) Inflammation in atherosclerosis. Nature 420:868-874
13. Ross R (1999) Atherosclerosis-an inflammatory disease. N Engl J Med 340:115-126
14. Rifai N, Tracy RP, Ridker PM (1999) Clinical efficacy of an automated high-sensitivity C-reactive protein assay. Clin Chem 45:2136-2141
15. Kono M, Tatsumi K, Saibara T, Nakamura A, Tanabe N, Takiguchi Y, Kuriyama T (2007) Obstructive sleep apnea syndrome is associated with some components of metabolic syndrome. Chest 131:1387-1392 (Pubitemid 46762343)
16. Lam JC, Lam B, Lam CL, Fong D, Wang JK, Tse HF, Lam KS, Ip MS (2006) Obstructive sleep apnea and the metabolic syndrome in community-based Chinese adults in Hong Kong. Respir Med 100:980-987
17. Punjabi NM, Beamer BA (2007) C-reactive protein is associated with sleep disordered breathing independent of adiposity. Sleep 30:29-34 (Pubitemid 46095380)
18. Lui MM, Lam JC, Mak HK, Xu A, Ooi C, Lam DC, Mak JC, Khong PL, Ip MS (2009) C-reactive protein is associated with obstructive sleep apnea independent of visceral obesity. Chest 135:950-956
19. Peled N, Kassirer M, Shitrit D, Kogan Y, Shlomi D, Berliner AS, Kramer MR (2007) The association of OSA with insulin resistance, inflammation and metabolic syndrome. Respir Med 101:1696-1701 (Pubitemid 46947878)
20. Sharma SK, Kumpawat S, Goel A, Banga A, Ramakrishnan L, Chaturvedi P (2007) Obesity, and not obstructive sleep apnea, is responsible for metabolic abnormalities in a cohort with sleep-disordered breathing. Sleep Med 8:12-17 (Pubitemid 46044133)
21. Barcelo A, Barbe F, Llompart E, Mayoralas LR, Ladaria A, Bosch M, Agusti AG (2004) Effects of obesity on C-reactive protein level and metabolic disturbances in male patients with obstructive sleep apnea. Am J Med 117:118-121 (Pubitemid 38953732)
22. Taheri S, Austin D, Lin L, Nieto FJ, Young T, Mignot E (2007) Correlates of serum C-reactive protein (CRP)-no association with sleep duration or sleep disordered breathing. Sleep 30:991-996 (Pubitemid 47221899)
23. Guilleminault C, Kirisoglu C, Ohayon MM (2004) C-reactive protein and sleep-disordered breathing. Sleep 27:1507-1511 (Pubitemid 40041619)
24. Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee (1995). World Health Organ Tech Rep Ser 854:1-452
25. Schulz H (2007) Phasic or transient? Comment on the terminology of the AASM manual for the scoring of sleep and associated events. J Clin Sleep Med 3:752
26. Lam DC, Xu A, Lam KS, Lam B, Lam JC, Lui MM, Ip MS (2009) Serum adipocyte-fatty acid binding protein level is elevated in severe OSA and correlates with insulin resistance. Eur Respir J 33:346-351
27. Tan CE, Ma S, Wai D, Chew SK, Tai ES (2004) Can we apply the national cholesterol education program adult treatment panel definition of the metabolic syndrome to Asians? Diabetes Care 27:1182-1186 (Pubitemid 38579787)
28. Oktay B, Akbal E, Firat H, Ardic S, Kizilgun M (2009) CPAP treatment in the coexistence of obstructive sleep apnea syndrome and metabolic syndrome, results of one year follow up. Acta Clin Belg 64:329-334
29. Mota PC, Drummond M, Winck JC, Santos AC, Almeida J, Marques JA (2011) APAP impact on metabolic syndrome in obstructive sleep apnea patients. Sleep Breath 15:665-672
30. Coughlin SR, Mawdsley L, Mugarza JA, Wilding JP, Calverley PM (2007) Cardiovascular and metabolic effects of CPAP in obese males with OSA. Eur Respir J 29:720-727 (Pubitemid 46554622)
31. Shamsuzzaman AS, Winnicki M, Lanfranchi P, Wolk R, Kara T, Accurso V, Somers VK (2002) Elevated C-reactive protein in patients with obstructive sleep apnea. Circulation 105:2462-2464 (Pubitemid 34568964)
32. Zouaoui Boudjeltia K, Van Meerhaeghe A, Doumit S, Guillaume M, Cauchie P, Brohee D, Vanhaeverbeek M, Kerkhofs M (2006) Sleep apnoea-hypopnoea index is an independent predictor of high-sensitivity C-reactive protein elevation. Respiration 73:243-246
33. Kapsimalis F, Varouchakis G, Manousaki A, Daskas S, Nikita D, Kryger M, Gourgoulianis K (2008) Association of sleep apnea severity and obesity with insulin resistance, C-reactive protein, and leptin levels in male patients with obstructive sleep apnea. Lung 186:209-217
34. Su MC, Chen YC, Huang KT, Wang CC, Lin MC, Lin HC (2013) Association of metabolic factors with high-sensitivity C-reactive protein in patients with sleep-disordered breathing. Eur Arch Otorhinolaryngol 270:749-754
35. Sharma SK, Mishra HK, Sharma H, Goel A, Sreenivas V, Gulati V, Tahir M (2008) Obesity, and not obstructive sleep apnea, is responsible for increased serum hs-CRP levels in patients with sleep-disordered breathing in Delhi. Sleep Med 9:149-156
36. Ryan S, Nolan GM, Hannigan E, Cunningham S, Taylor C, McNicholas WT (2007) Cardiovascular risk markers in obstructive sleep apnoea syndrome and correlation with obesity. Thorax 62:509-514 (Pubitemid 46910129)
37. Schiza SE, Mermigkis C, Panagiotis P, Bouloukaki I, Kallergis E, Tzanakis N, Tzortzaki E, Vlachaki E, Siafakas NM (2010) C-reactive protein evolution in obstructive sleep apnoea patients under CPAP therapy. Eur J Clin Invest 40:968-975
38. Ishida K, Kato M, Kato Y, Yanagihara K, Kinugasa Y, Kotani K, Igawa O, Hisatome I, Shigemasa C, Somers VK (2009) Appropriate use of nasal continuous positive airway pressure decreases elevated C-reactive protein in patients with obstructive sleep apnea. Chest 136:125-129
39. Kohler M, Ayers L, Pepperell JC, Packwood KL, Ferry B, Crosthwaite N, Craig S, Siccoli MM, Davies RJ, Stradling JR (2009) Effects of continuous positive airway pressure on systemic inflammation in patients with moderate to severe obstructive sleep apnoea: a randomised controlled trial. Thorax 64:67-73