NOTCH4 is a potential therapeutic target for triple-negative breast cancer

Anticancer Research

Volumn 34, Issue 1, 2014, Pages 69-80

  Nagamatsu, Iori ^a   Onishi, Hideya ^a   Matsushita, Shojiro ^a   Kubo, Makoto ^a   Kai, Masaya ^a   Imaizumi, Akira ^b   Nakano, Kenji ^c   Hattori, Masami ^a   Oda, Yoshinao ^a   Tanaka, Masao ^a   Katano, Mitsuo ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b Shukoukai Inc   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

Author keywords

Breast cancer; Invasion; NOTCH4; Proliferation; Therapeutic target; Triple negative breast cancer

Indexed keywords

NOTCH4 RECEPTOR; SMALL INTERFERING RNA; MESSENGER RNA; NOTCH RECEPTOR; NOTCH4 PROTEIN, HUMAN; ONCOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CARCINOGENESIS; CANCER SIZE; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; GENETIC TRANSFECTION; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TRIPLE NEGATIVE BREAST CANCER; TUMOR INVASION; TUMOR XENOGRAFT; ANIMAL; APOPTOSIS; BREAST CANCER; CELL ADHESION; CELL MOTION; DRUG ANTAGONISM; ENZYME IMMUNOASSAY; GENETICS; HUMAN; INVASION; METABOLISM; NOTCH4; PATHOLOGY; PROLIFERATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCID MOUSE; THERAPEUTIC TARGET; TRIPLE-NEGATIVE BREAST CANCER; WESTERN BLOTTING;

BREAST CANCER; INVASION; NOTCH4; PROLIFERATION; THERAPEUTIC TARGET; TRIPLE-NEGATIVE BREAST CANCER;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL ADHESION; CELL MOVEMENT; CELL PROLIFERATION; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; MICE; MICE, SCID; PROTO-ONCOGENE PROTEINS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, NOTCH; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; TRIPLE NEGATIVE BREAST NEOPLASMS;

EID: 84897020355     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Lee J, Sehrawat A and Singh SV: Withaferin A causes activation of NOTCH2 and NOTCH4 in human breast cancer cells. Breast Cancer Res Treat 136: 45-56, 2010.
2. Clementz AG, Rogowski A, Pandya K, Miele L and Osipo C: NOTCH-1 and NOTCH-4 are novel gene targets of PEA3 in breast cancer: Novel therapeutic implications. Breast Cancer Res 13: R63, 2011.
3. Pasca di Magliano M and Hebrok M: Hedgehog signaling in cancer formation and maintenance. Nat Rev Cancer 3: 903-911, 2003.
4. Onishi H and Katano M: Hedgehog signaling pathway as a therapeutic target in various types of cancer. Cancer Sci 102: 1756-1760, 2011.
5. Nagai S, Nakamura M, Yanai K, Wada J, Akiyoshi T, Nakashima H, Ohuchida K, Sato N, Tanaka M and Katano M: Gli1 contributes to the invasiveness of pancreatic cancer through matrix metalloproteinase-9 activation. Cancer Sci 99: 1377-1384, 2008.
6. Souzaki M, Kubo M, Kai M, Kameda C, Tanaka H, Taguchi T, Tanaka M, Onishi H and Katano M: Hedgehog signaling pathway mediates the progression of non-invasive breast cancer to invasive breast cancer. Cancer Sci 102: 373-381, 2011.
7. Onishi H, Morifuji Y, Kai M, Suyama K, Iwasaki H and Katano M. Hedgehog inhibitor decreases chemosensitivity to 5-fluorouracil and gemcitabine under hypoxic conditions in pancreatic cancer. Cancer Sci 103: 1272-1279, 2012.
8. Onishi H, Kai M, Odate S, Iwasaki H, Morifuji Y, Ogino T, Morisaki T, Nakashima Y, Katano M: Hypoxia activates the hedgehog signaling pathway in a ligand-independent manner by up-regulation of SMO transcription in pancreatic cancer. Cancer Sci 102: 1144-1150, 2011.
9. Wang J, Fu L, Gu F and Ma Y: Notch1 is involved in migration and invasion of human breast cancer cells. Oncol Report 26: 1295-1303, 2011.
10. Krop I, Demuth T, Guthrie T, Wen PY, Mason WP, Chinnaiyan P, Butowski N, Groves MD, Kesari S, Freedman SJ, Blackman S, Watters J, Loboda A, Podtelezhnikov A, Lunceford J, Chen C, Giannotti M, Hing J, Beckman R and Lorusso P: Phase I pharmacologic and pharmacodynamic study of the gamma secretase (NOTCH) inhibitor MK-0752 in adult patients with advanced solid tumors. J Clin Oncol 30: 2307-2313, 2012.
11. Tasaka T, Akiyoshi T, Yamaguchi K, Tanaka M, Onishi H and Katano M: Gamma-secretase complexes regulate the responses of human pancreatic ductal adenocarcinoma cells to taxanes. Anticancer Res 30: 4999-5010, 2010.
12. Dunwoodie SL, Henrique D, Harrison SM and Beddington RS: Mouse DII3: A novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo. Development 124: 3065-3076, 1997.
13. Lindsell CE, Shawber CJ, Boulter J and Weinmaster G: Jagged: A mammalian ligand that activates Notch1. Cell 80: 909-917, 1995.
14. Shawber C, Boulter J, Lindsell CE and Weinmaster G: Jagged2: A serrate-like gene expressed during rat embryogenesis. Dev Biol 180: 370-376, 1996.
15. Callahan R and Raafat A: A Notch signaling in mammary gland tumorigenesis. J Mammary Gland Biol Neoplasia 6: 23-26, 2001.
16. Reedijk M, Odorcic S, Chang L, Zhang H, Miller N, McCready DR, Lockwood G and Egan SE: High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival. Cancer Res 65: 8530-8537, 2005.
17. Dickson BC, Mulligan AM, Zhang H, Lockwood G, O'Malley FP, Egan SE and Reedijk M: High-level JAG1 mRNA and protein predict poor outcome in breast cancer. Mod Pathol 20: 685-693, 2007.
18. Reedijk M, Pinnaduwage D, Dickson BC, Mulligan AM, Zhang H, Bull SB, O'Malley FP, Egan SE and Andrulis IL: JAG1 expression is associated with a basal phenotype and recurrence in lymph node-negative breast cancer. Breast Cancer Res Treat 111: 439-448, 2008.
19. Hirose H, Ishii H, Mimori K, Ohta D, Ohkuma M, Tsujii H, Saito T, Sekimoto M, Doki Y and Mori M: Notch pathway as candidate therapeutic target in Her2/Neu/ErbB2 receptor-negative breast tumors. Oncol Rep 23: 35-43, 2010.
20. Hu C, Dievart A, Lupien M, Calvo E, Tremblay G and Jolicoeur P: Overexpression of activated murine Notch1 and Notch3 in transgenic mice blocks mammary gland development and induces mammary tumors. Am J Pathol 168: 973-990, 2006.
21. Stylianou S, Clarke RB and Brennan K: Aberrant activation of notch signaling in human breast cancer. Cancer Res 66: 1517-1525, 2006.
22. Harrison H, Farnie G, Howell SJ, Rock RE, Stylianou S, Brennan KR, Bundred NJ and Clarke RB: Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor. Cancer Res 70: 709-718, 2010.
23. Miele L, Golde T and Osborne B: Notch signaling in cancer. Curr Mol Med 6: 905-918, 2006.
24. Parr C, Watkins G and Jiang WG: The possible correlation of NOTCH1 and NOTCH2 with clinical outcome and tumour clinicopathological parameters in human breast cancer. Int J Mol Med 14: 779-786, 2004.
25. Zardawi SJ, Zardawi I, McNeil CM, Millar EK, McLeod D, Morey AL, Crea P, Murphy NC, Pinese M, Lopez-Knowles E, Oakes SR, Ormandy CJ, Qiu MR, Hamilton A, Spillane A, Soon Lee C, Sutherland RL, Musgrove EA and O'Toole SA: High NOTCH1 protein expression is an early event in breast cancer development and is associated with the HER-2 molecular subtype. Histopathology 56: 286-296, 2010.
26. Rizzo P, Miao H, D'Souza G, Osipo C, Song LL, Yun J, Zhao H, Mascarenhas J, Wyatt D, Antico G, Hao L, Yao K, Rajan P, Hicks C, Siziopikou K, Selvaggi S, Bashir A, Bhandari D, Marchese A, Lendahl U, Qin JZ, Tonetti DA, Albain K, Nickoloff BJ and Miele L: Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches. Cancer Res 68: 5226-5235, 2008.
27. Mittal S, Subramanyam D, Dey D, Kumar RV and Rangarajan A: Cooperation of NOTCH and RAS/MAPK signaling pathways in human breast carcinogenesis. Mol Cancer 8: 128, 2009.
28. O'Neill CF, Urs S, Cinelli C, Lincoln A, Nadeau RJ, León R, Toher J, Mouta-Bellum C, Friesel RE and Liaw L: NOTCH2 signaling induces apoptosis and inhibits human MDA-MB-231 xenograft growth. Am J Pathol 171: 1023-1036, 2007.
29. Al-Hajj M and Wicha MS: Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 100: 3983-3988, 2003.
30. Chen J, Imanaka N, Chen J and Griffin JD: Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion. Br J Cancer 102: 351-360, 2009.