Pegylated G-CSF inhibits blood cell depletion, increases platelets, blocks splenomegaly, and improves survival after whole-body ionizing irradiation but not after irradiation combined with burn

Oxidative Medicine and Cellular Longevity

Volumn 2014, Issue , 2014, Pages

  Kiang, Juliann G ^a,b,c   Zhai, Min ^a   Liao, Pei Jyun ^a   Bolduc, David L ^a   Elliott, Thomas B ^a   Gorbunov, Nikolai V ^a  

^a ARMED FORCES RADIOBIOLOGY RESEARCH INSTITUTE   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^c Uniformed Services University of the Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; HEMOGLOBIN; IONIZING RADIATION; MAMMALS; PLATELETS;

BONE MARROW CELLS; HEMOGLOBIN LEVELS; IONIZING IRRADIATION; OBSERVATION PERIOD; PHOTON RADIATION; RADIATION INJURY; RADIATION-INDUCED; RADIOLOGICAL ACCIDENTS;

IRRADIATION;

GRANULOCYTE COLONY STIMULATING FACTOR; HEMOGLOBIN; PEGYLATED GRANULOCYTE COLONY STIMULATING FACTOR; UNCLASSIFIED DRUG; MACROGOL DERIVATIVE;

ANEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY SURFACE; BONE MARROW CELL; BURN; COBALT THERAPY; CONTROLLED STUDY; CYTOPENIA; ERYTHROPENIA; FEMALE; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; LYMPHOCYTE; MORTALITY; MOUSE; NEUTROPENIA; NEUTROPHIL; NONHUMAN; SPLENOMEGALY; THROMBOCYTE; THROMBOCYTOPENIA; WEIGHT REDUCTION; WHOLE BODY RADIATION; ANIMAL; BLOOD; BODY WEIGHT; BURNS; CELL COUNT; CHEMISTRY; COMPLICATION; DRUG EFFECTS; IONIZING RADIATION; METABOLISM; ORGAN SIZE; PATHOLOGY; RADIATION RESPONSE; SPLEEN; SURVIVAL;

ANIMALS; BLOOD PLATELETS; BODY WEIGHT; BONE MARROW CELLS; BURNS; CELL COUNT; FEMALE; GRANULOCYTE COLONY-STIMULATING FACTOR; MICE; ORGAN SIZE; POLYETHYLENE GLYCOLS; RADIATION, IONIZING; SPLEEN; SPLENOMEGALY; SURVIVAL ANALYSIS; WHOLE-BODY IRRADIATION;

EID: 84896996310     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2014/481392     Document Type: Article

References (40)

1. Kiang J. G., Garrison B. R., Burns T. M., Zhai M., Dews I. C., Ney P. H., Fukumoto R., Cary L. H., Elliott T. B., Ledney G. D., Wound trauma alters ionizing radiation dose assessment. Cell and Bioscience 2012 2 1, article 20 12 10.1186/2045-3701-2-20
2. Kiang J. G., Garrison B. R., Fukumoto R., Elliott T. B., Ciprofloxacin inhibits gamma radiation-induced increases in γ -H2AX, p53 phosphorylation in human tumor cells and p53 phosphorylation, Gadd45a, bax, and Bcl-2 gene expression in human peripheral blood cells. Proceedings of the 56th Radiation Research Society Annual Meeting September 2010 Maui, Hawaii, USA 188
3. Fukumoto R., Kiang J. G., Geldanamycin analog 17-DMAG limits apoptosis in human peripheral blood cells by inhibition of p53 activation and its interaction with heat-shock protein 90 kDa after exposure to ionizing radiation. Radiation Research 2011 176 3 333 345 2-s2.0-80052179384 10.1667/RR2534.1
4. Fukumoto R., Cary L. H., Gorbunov N. V., Elliott T. B., Kiang J. G., Ciprofloxacin modulates cytokine profiles, accelerates bone marrow recovery and mitigates ileum injury after radiation combined with wound trauma. PLoS ONE 2013 8 3 11 e58389 10.1371/journal.pone.0058389
5. Ledney G. D., Elliott T. B., Combined injury: factors with potential to impact radiation dose assessments. Health Physics 2010 98 2 145 152 2-s2.0-75649144772 10.1097/01.HP.0000348466.09978.77
6. Kiang J. G., Ledney G. D., Skin injuries reduce survival and modulate corticosterone, C-reactive protein, complement component 3, IgM, and prostaglandin E2 after whole-body reactor-produced mixed field (n + γ -photons) irradiation. Oxidative Medicine and Cellular Longevity 2013 2013 10 821541 10.1155/2013/821541
7. Kiang J. G., Jiao W., Cary L. H., Mog S. R., Elliott T. B., Pellmar T. C., Ledney G. D., Wound trauma increases radiation-induced mortality by activation of iNOS pathway and elevation of cytokine concentrations and bacterial infection. Radiation Research 2010 173 3 319 332 2-s2.0-77749233821 10.1667/RR1892.1
8. Berger M. E., Christensen D. M., Lowry P. C., Jones O. W., Wiley A. L., Medical management of radiation injuries: current approaches. Occupational Medicine 2006 56 3 162 172 2-s2.0-33646259011 10.1093/occmed/kql011
9. Waselenko J. K., MacVittie T. J., Blakely W. F., Pesik N., Wiley A. L., Dickerson W. E., Tsu H., Confer D. L., Coleman C. N., Seed T., Lowry P., Armitage J. O., Dainiak N., Medical management of the acute radiation syndrome: recommendations of the strategic national stockpile radiation working group. Annals of Internal Medicine 2004 140 12 1037 1051 2-s2.0-20244382799
10. Molineux G., The design and development of pegfilgrastim (PEG-rmetHuG-CSF, Neulasta). Current Pharmaceutical Design 2004 10 11 1235 1244 2-s2.0-1842535270 10.2174/1381612043452613 (Pubitemid 38425903)
11. Metcalf D., Neu H. C., The role of the colony-stimulating factors in the treatment of infections. Frontiers of Infectious Diseases: New Antibacterial Strategies: Proceedings of an International Symposium Sponsored by Glaxo Research, Brocker Hall, Hertfordshire 30 June-3 July 1990 1990 New York, NY, USA Churchill Livingstone
12. Metcalf D., Hematopoietic cytokines. Blood 2008 111 2 485 491 2-s2.0-38349157811 10.1182/blood-2007-03-079681
13. Badiavas E. V., Abedi M., Butmarc J., Falanga V., Quesenberry P., Participation of bone marrow derived cells in cutaneous wound healing. Journal of Cellular Physiology 2003 196 2 245 250 2-s2.0-0038798707 10.1002/jcp.10260 (Pubitemid 36775870)
14. Bertho J. M., Griffiths N. M., Gourmelon P., The medical diagnosis and treatment of radiation overexposed people. 2003, http://irpa11.irpa.net/pdfs/RC- 7a.pdf
15. Montgomery C. A., Oncologic and toxicologic research: alleviation and control of pain and distress in laboratory animals. Cancer Bulletin 1990 42 230 237
16. Tomasivic S. P., Coghlan L. G., Gray K. N., Mastromarino A. J., Travis E. L., IACUC evaluation of experiments requiring death as an end point: a cancer center's recommendations. Lab Animal 1988 31 34
17. International Standardization Organization, ASTM International, Standard Practice for Use of an Alanine-EPR Dosimetry System 2004 West Conshohocken, Pa, USA ISO, Geneva, Switzerland; ASTM International Standard 51607:2004(E)
18. Lord B. I., Woolford L. B., Molineux G., Kinetics of neutrophil production in normal and neutropenic animals during the response to filgrastim (r-metHu G-CSF) or filgrastim SD/01 (PEG-r-metHu G-CSF). Clinical Cancer Research 2001 7 7 2085 2090 2-s2.0-0034772725 (Pubitemid 32994848)
19. van Spriel A. B., van den Herik-Oudijk I. E., van de Winkel J. G. J., A single injection of polyethylene-glycol granulocyte colony-stimulating factor strongly prolongs survival of mice with systemic candidiasis. Cytokine 2000 12 6 666 670 2-s2.0-0033924288 10.1006/cyto.1999.0670 (Pubitemid 30453495)
20. Neelis K. J., Hartong S. C. C., Egeland T., Thomas G. R., Eaton D. L., Wagemaker G., The efficacy of single-dose administration of thrombopoietin with coadministration of either granulocyte/macrophage or granulocyte colony-stimulating factor in myelosuppressed rhesus monkeys. Blood 1997 90 7 2565 2573 2-s2.0-0030799430 (Pubitemid 27413465)
21. Alpen E. L., Sheline G. E., The combined effects of thermal burns and whole-body X-radiation on survival time and mortality. Annuls of Surgery 1954 140 1 113 118 10.1097/00000658-195407000-00013
22. Valeriote F. A., Baker D. G., The combined effects of thermal trauma and X-irradiation on early. Radiation Research 1964 22 693 702 2-s2.0-44849092416
23. Korlof B., Infection of burns. I. A bacteriological and clinical study of 99 cases. II. Animal experiments: burns and total body x-irradiation. Acta Chirurgica Scandinavica, Supplementum 1956 209 1 144
24. Brooks J. W., Evans E. I., Ham W. T. Jr., Reid J. D., The influence of external body radiation on mortality from thermal burns. Annals of Surgery 1952 136 3 533 545 2-s2.0-0005475158
25. Baxter H., Drummond J. A., Stephens-Newsham L. G., Randall R. G., Studies on acute total body irradiation in animals. I. Effect of streptomycin following exposure to a thermal burn and irradiation. Plastic Reconstruction Surgery 1953 12 6 439 445 10.1097/00006534-195312000-00007
26. Ledney G. D., Elliott T. B., Moore M. M., Mossman K. L., Mills W. A., Modulations of mortality by tissue trauma and sepsis in mice after radiation injury. The Biological Basis of Radiation Protection Practice 1992 Baltimore, Md, USA Williams & Wilkins 202 217
27. Ledney G. D., Stewart D. A., Exum E. D., Sheehy P. A., Skin wound-enhanced survival and myelocytopoiesis in mice after whole-body irradiation. Acta Radiologica: Oncology 1981 20 1 29 38 2-s2.0-0019455711 (Pubitemid 11117336)
28. Palmer J. L., Deburghgraeve C. R., Bird M. D., Hauer-Jensen M., Kovacs E. J., Development of a combined radiation and burn injury model. Journal of Burn Care and Research 2011 32 2 317 323 2-s2.0-79952449920 10.1097/BCR. 0b013e31820aafa9
29. Jacob A., Shah K. G., Wu R., Wang P., Ghrelin as a novel therapy for radiation combined injury. Molecular Medicine 2010 16 3-4 137 143 2-s2.0-77649162874 10.2119/molmed.2009.00154
30. Zou Z., Sun H., Su Y., Cheng T., Luo C., Progress in research on radiation combined injury in China. Radiation Research 2008 169 6 722 729 2-s2.0-44849125743 10.1667/RR1284.1 (Pubitemid 351793462)
31. Koenig K. L., Goans R. E., Hatchett R. J., Mettler F. A. Jr., Schumacher T. A., Noji E. K., Jarrett D. G., Medical treatment of radiological casualties: current concepts. Annals of Emergency Medicine 2005 45 6 643 652 2-s2.0-20444456298 10.1016/j.annemergmed.2005.01.020 (Pubitemid 40812900)
32. Lausevic Z., Lausevic M., Trbojevic-Stankovic J., Krstic S., Stojimirovic B., Predicting multiple organ failure in patients with severe trauma. Canadian Journal of Surgery 2008 51 2 97 102 2-s2.0-41949131405
33. MacVittie T. J., Farese A. M., Jackson W. III, Defining the full therapeutic potential of recombinant growth factors in the post radiation-accident environment: the effect of supportive care plus administration of G-CSF. Health Physics 2005 89 5 546 555 2-s2.0-26844521492 10.1097/01.HP.0000173143.69659.5b (Pubitemid 41463888)
34. Singh V. K., Fatanmi O. O., Singh P. K., Whitnall M. H., Role of radiation-induced granulocyte colony-stimulating factor in recovery from whole body gamma-irradiation. Cytokine 2012 58 3 406 414 2-s2.0-84860351592 10.1016/j.cyto.2012.03.011
35. Scholz M., Ackermann M., Engel C., Emmrich F., Loeffler M., Kamprad M., A pharmacokinetic model of filgrastim and pegfilgrastim application in normal mice and those with cyclophosphamide-induced granulocytopaenia. Cell Proliferation 2009 42 6 813 822 2-s2.0-70350442575 10.1111/j.1365-2184.2009. 00638.x
36. Chen T., Burke K. A., Zhan Y., Wang X., Shibata D., Zhao Y., IL-12 facilitates both the recovery of endogenous hematopoiesis and the engraftment of stem cells after ionizing radiation. Experimental Hematology 2007 35 2 203 213 2-s2.0-33846349940 10.1016/j.exphem.2006.10.002 (Pubitemid 46135811)
37. Millot S., Andrieu V., Letteron P., Lyoumi S., Hurtado-Nedelec M., Karim Z., Thibaudeau O., Bennada S., Charrier J., Lasocki S., Beaumont C., Erythropoietin stimulates spleen BMP4-dependent stress erythropoiesis and partially corrects anemia in a mouse model of generalized inflammation. Blood 2010 116 26 6072 6081 2-s2.0-78650643140 10.1182/blood-2010-04-281840
38. Russell J. A., Management of sepsis. The New England Journal of Medicine 2006 355 16 1699 1713 2-s2.0-33750047495 10.1056/NEJMra043632 (Pubitemid 44583960)
39. Perl M., Chung C., Swan R., Ayala A., Role of programmed cell death in the immunopathogenesis of sepsis. Drug Discovery Today 2007 4 4 223 230 2-s2.0-47249103385 10.1016/j.ddmec.2008.02.010
40. Gorbunov N. V., Garrison B. R., McDaniel D. P., Zhai M., Liao P.-J., Nurmemet D., Kiang J. G., Adaptive redox response of mesenchymal stromal cells to stimulation with lipopolysaccharide inflammagen: mechanisms of remodeling of tissue barriers in sepsis. Oxidative Medicine and Cellular Longevity 2013 2013 16 186795 10.1155/2013/186795