Myosin chaperones

Current Opinion in Structural Biology

Volumn 25, Issue , 2014, Pages 9-15

  Hellerschmied, Doris ^a   Clausen, Tim ^a  

^a RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; MYOSIN; SHE4 PROTEIN; TETRATRICOPEPTIDE REPEAT PROTEIN; UCS PROTEIN; UNC 45 PROTEIN; UNCLASSIFIED DRUG; PROTEIN AGGREGATE;

BINDING AFFINITY; CRYSTAL STRUCTURE; MYOFILAMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTEIN SUBUNIT; PROTEIN TRANSPORT; REVIEW; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION; CHEMISTRY; METABOLISM;

MOLECULAR CHAPERONES; MYOSINS; PROTEIN AGGREGATES; PROTEIN FOLDING;

EID: 84896992269     PISSN: 0959440X     EISSN: 1879033X     Source Type: Journal    
DOI: 10.1016/j.sbi.2013.11.002     Document Type: Review

References (49)

1. Hartman M.A., Finan D., Sivaramakrishnan S., Spudich J.A. Principles of unconventional myosin function and targeting. Annu Rev Cell Dev Biol 2011, 27:133-155.
2. Hammer J.A., Sellers J.R. Walking to work: roles for class V myosins as cargo transporters. Nat Rev Mol Cell Biol 2011, 13:13-26.
3. Clark K.A., McElhinny A.S., Beckerle M.C., Gregorio C.C. Striated muscle cytoarchitecture: an intricate web of form and function. Annu Rev Cell Dev Biol 2002, 18:637-706.
4. Sweeney H.L., Houdusse A. Structural and functional insights into the myosin motor mechanism. Annu Rev Biophys 2010, 39:539-557.
5. Odronitz F., Kollmar M. Drawing the tree of eukaryotic life based on the analysis of 2,269 manually annotated myosins from 328 species. Genome Biol 2007, 8:R196.
6. Woodhead J.L., Zhao F.Q., Craig R., Egelman E.H., Alamo L., Padron R. Atomic model of a myosin filament in the relaxed state. Nature 2005, 436:1195-1199.
7. Schnorrer F., Schonbauer C., Langer C.C., Dietzl G., Novatchkova M., Schernhuber K., Fellner M., Azaryan A., Radolf M., Stark A., et al. Systematic genetic analysis of muscle morphogenesis and function in Drosophila. Nature 2010, 464:287-291.
8. Srikakulam R., Winkelmann D.A. Myosin II folding is mediated by a molecular chaperonin. J Biol Chem 1999, 274:27265-27273.
9. Chow D., Srikakulam R., Chen Y., Winkelmann D.A. Folding of the striated muscle myosin motor domain. J Biol Chem 2002, 277:36799-36807.
10. Srikakulam R., Winkelmann D.A. Chaperone-mediated folding and assembly of myosin in striated muscle. J Cell Sci 2004, 117:641-652.
11. Mayer M.P., Bukau B. Hsp70 chaperones: cellular functions and molecular mechanism. Cell Mol Life Sci 2005, 62:670-684.
12. Bukau B., Weissman J., Horwich A. Molecular chaperones and protein quality control. Cell 2006, 125:443-451.
13. Taipale M., Jarosz D.F., Lindquist S. HSP90 at the hub of protein homeostasis: emerging mechanistic insights. Nat Rev Mol Cell Biol 2010, 11:515-528.
14. Gaiser A.M., Kaiser C.J., Haslbeck V., Richter K. Downregulation of the hsp90 system causes defects in muscle cells of Caenorhabditis elegans. PLoS ONE 2011, 6:e25485.
15. Du S.J., Li H., Bian Y., Zhong Y. Heat-shock protein 90alpha1 is required for organized myofibril assembly in skeletal muscles of zebrafish embryos. Proc Natl Acad Sci U S A 2008, 105:554-559.
16. Hawkins T.A., Haramis A.P., Etard C., Prodromou C., Vaughan C.K., Ashworth R., Ray S., Behra M., Holder N., Talbot W.S., et al. The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesis. Development 2008, 135:1147-1156.
17. Toi H., Fujimura-Kamada K., Irie K., Takai Y., Todo S., Tanaka K. She4p/Dim1p interacts with the motor domain of unconventional myosins in the budding yeast, Saccharomyces cerevisiae. Mol Biol Cell 2003, 14:2237-2249.
18. Wesche S., Arnold M., Jansen R.P. The UCS domain protein She4p binds to myosin motor domains and is essential for class I and class V myosin function. Curr Biol 2003, 13:715-724.
19. Lord M., Sladewski T.E., Pollard T.D. Yeast UCS proteins promote actomyosin interactions and limit myosin turnover in cells. Proc Natl Acad Sci U S A 2008, 105:8014-8019.
20. Barral J.M., Hutagalung A.H., Brinker A., Hartl F.U., Epstein H.F. Role of the myosin assembly protein UNC-45 as a molecular chaperone for myosin. Science 2002, 295:669-671.
21. Gazda L., Pokrzywa W., Hellerschmied D., Lowe T., Forne I., Mueller-Planitz F., Hoppe T., Clausen T. The myosin chaperone UNC-45 is organized in tandem modules to support myofilament formation in C. elegans. Cell 2013, 152:183-195.
22. Kachur T., Ao W., Berger J., Pilgrim D. Maternal UNC-45 is involved in cytokinesis and colocalizes with non-muscle myosin in the early Caenorhabditis elegans embryo. J Cell Sci 2004, 117:5313-5321.
23. Berteaux-Lecellier V., Zickler D., Debuchy R., Panvier-Adoutte A., Thompson-Coffe C., Picard M. A homologue of the yeast SHE4 gene is essential for the transition between the syncytial and cellular stages during sexual reproduction of the fungus Podospora anserina. EMBO J 1998, 17:1248-1258.
24. Jansen R.P., Dowzer C., Michaelis C., Galova M., Nasmyth K. Mother cell-specific HO expression in budding yeast depends on the unconventional myosin myo4p and other cytoplasmic proteins. Cell 1996, 84:687-697.
25. Wendland B., McCaffery J.M., Xiao Q., Emr S.D. A novel fluorescence-activated cell sorter-based screen for yeast endocytosis mutants identifies a yeast homologue of mammalian eps15. J Cell Biol 1996, 135:1485-1500.
26. Shi H., Blobel G. UNC-45/CRO1/She4p (UCS) protein forms elongated dimer and joins two myosin heads near their actin binding region. Proc Natl Acad Sci U S A 2010, 107:21382-21387.
27. Wong K.C., Naqvi N.I., Iino Y., Yamamoto M., Balasubramanian M.K. Fission yeast Rng3p: an UCS-domain protein that mediates myosin II assembly during cytokinesis. J Cell Sci 2000, 113(Pt 13):2421-2432.
28. Amorim M.J., Mata J. Rng3, a member of the UCS family of myosin co-chaperones, associates with myosin heavy chains cotranslationally. EMBO Rep 2009, 10:186-191.
29. Kachur T.M., Audhya A., Pilgrim D.B. UNC-45 is required for NMY-2 contractile function in early embryonic polarity establishment and germline cellularization in C. elegans. Dev Biol 2008, 314:287-299.
30. Barral J.M., Bauer C.C., Ortiz I., Epstein H.F. Unc-45 mutations in Caenorhabditis elegans implicate a CRO1/She4p-like domain in myosin assembly. J Cell Biol 1998, 143:1215-1225.
31. Ao W., Pilgrim D. Caenorhabditis elegans UNC-45 is a component of muscle thick filaments and colocalizes with myosin heavy chain B, but not myosin heavy chain A. J Cell Biol 2000, 148:375-384.
32. Melkani G.C., Bodmer R., Ocorr K., Bernstein S.I. The UNC-45 chaperone is critical for establishing myosin-based myofibrillar organization and cardiac contractility in the Drosophila heart model. PLoS ONE 2011, 6:e22579.
33. Lee C.F., Melkani G.C., Yu Q., Suggs J.A., Kronert W.A., Suzuki Y., Hipolito L., Price M.G., Epstein H.F., Bernstein S.I. Drosophila UNC-45 accumulates in embryonic blastoderm and in muscles, and is essential for muscle myosin stability. J Cell Sci 2011, 124:699-705.
34. Liu L., Srikakulam R., Winkelmann D.A. Unc45 activates Hsp90-dependent folding of the myosin motor domain. J Biol Chem 2008, 283:13185-13193.
35. Price M.G., Landsverk M.L., Barral J.M., Epstein H.F. Two mammalian UNC-45 isoforms are related to distinct cytoskeletal and muscle-specific functions. J Cell Sci 2002, 115:4013-4023.
36. Anderson M.J., Pham V.N., Vogel A.M., Weinstein B.M., Roman B.L. Loss of unc45a precipitates arteriovenous shunting in the aortic arches. Dev Biol 2008, 318:258-267.
37. Epping M.T., Meijer L.A., Bos J.L., Bernards R. UNC45A confers resistance to histone deacetylase inhibitors and retinoic acid. Mol Cancer Res 2009, 7:1861-1870.
38. Chadli A., Graham J.D., Abel M.G., Jackson T.A., Gordon D.F., Wood W.M., Felts S.J., Horwitz K.B., Toft D. GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway. Mol Cell Biol 2006, 26:1722-1730.
39. Wohlgemuth S.L., Crawford B.D., Pilgrim D.B. The myosin co-chaperone UNC-45 is required for skeletal and cardiac muscle function in zebrafish. Dev Biol 2007, 303:483-492.
40. Bernick E.P., Zhang P.J., Du S. Knockdown and overexpression of Unc-45b result in defective myofibril organization in skeletal muscles of zebrafish embryos. BMC Cell Biol 2010, 11:70.
41. Geach T.J., Zimmerman L.B. Paralysis and delayed Z-disc formation in the Xenopus tropicalis unc45b mutant dicky ticker. BMC Dev Biol 2010, 10:75.
42. Etard C., Roostalu U., Strahle U. Lack of Apobec2-related proteins causes a dystrophic muscle phenotype in zebrafish embryos. J Cell Biol 2010, 189:527-539.
43. Etard C., Roostalu U., Strahle U. Shuttling of the chaperones Unc45b and Hsp90a between the A band and the Z line of the myofibril. J Cell Biol 2008, 180:1163-1175.
44. Lee C.F., Hauenstein A.V., Fleming J.K., Gasper W.C., Engelke V., Sankaran B., Bernstein S.I., Huxford T. X-ray crystal structure of the UCS domain-containing UNC-45 myosin chaperone from Drosophila melanogaster. Structure 2011, 19:397-408.
45. Hoppe T., Cassata G., Barral J.M., Springer W., Hutagalung A.H., Epstein H.F., Baumeister R. Regulation of the myosin-directed chaperone UNC-45 by a novel E3/E4-multiubiquitylation complex in C. elegans. Cell 2004, 118:337-349.
46. Landsverk M.L., Li S., Hutagalung A.H., Najafov A., Hoppe T., Barral J.M., Epstein H.F. The UNC-45 chaperone mediates sarcomere assembly through myosin degradation in Caenorhabditis elegans. J Cell Biol 2007, 177:205-210.
47. Janiesch P.C., Kim J., Mouysset J., Barikbin R., Lochmuller H., Cassata G., Krause S., Hoppe T. The ubiquitin-selective chaperone CDC-48/p97 links myosin assembly to human myopathy. Nat Cell Biol 2007, 9:379-390.
48. Stanley B.A., Shaw J., Arab S., Liu P., Kirshenbaum L.A., Van Eyk J.E. UNC-45B exhibits increased abundance in heart failure patients and functions as a novel dual regulator of myosin heavy chain transcription and assembly. Circulation 2007, 116:170.
49. Comyn S.A., Pilgrim D. Lack of developmental redundancy between Unc45 proteins in zebrafish muscle development. PLoS ONE 2012, 7:e48861.