UNC45A confers resistance to histone deacetylase inhibitors and retinoic acid

Molecular Cancer Research

Volumn 7, Issue 11, 2009, Pages 1861-1870

  Epping, Mirjam T ^a   Meijer, Lars A T ^b   Bos, Johannes L ^b   Bernards, René ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE DEACETYLASE INHIBITOR; PHOSPHOPROTEIN; PROTEIN UNC45A; RETINOIC ACID; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; GENE EXPRESSION; GENETIC SCREENING; HUMAN; NEUROBLASTOMA; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE;

AMINO ACID SEQUENCE; ANIMALS; BONE NEOPLASMS; CELL DIFFERENTIATION; CELL GROWTH PROCESSES; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MOLECULAR SEQUENCE DATA; NEUROBLASTOMA; OSTEOSARCOMA; RECEPTORS, RETINOIC ACID; SIGNAL TRANSDUCTION; TRETINOIN;

VERTEBRATA;

EID: 72449192778     PISSN: 15417786     EISSN: None     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-09-0187     Document Type: Article

References (29)

1. Barral JM, Bauer CC, Ortiz I, Epstein HF. Unc-45 mutations in Caenorhabditis elegans implicate a CRO1/She4p-like domain in myosin assembly. J Cell Biol 1998;143:1215-1225 (Pubitemid 28559823)
2. Venolia L, Waterston RH. The unc-45 gene of Caenorhabditis elegans is an essential muscle-affecting gene with maternal expression. Genetics 1990;126:345-353 (Pubitemid 20341017)
3. Price MG, Landsverk ML, Barral JM, Epstein HF. Two mammalian UNC-45 isoforms are related to distinct cytoskeletal and muscle-specific functions. J Cell Sci 2002;115:4013-4023
4. Hutagalung AH, Landsverk ML, Price MG, Epstein HF. The UCS family of myosin chaperones. J Cell Sci 2002;115:3983-3990
5. Barral JM, Hutagalung AH, Brinker A, Hartl FU, Epstein HF. Role of the myosin assembly protein UNC-45 as a molecular chaperone for myosin. Science 2002;295:669-671 (Pubitemid 34111823)
6. Etard C, Behra M, Fischer N, Hutcheson D, Geisler R, Strahle U. The UCS factor Steif/Unc-45b interacts with the heat shock protein Hsp90a during myofibrillogenesis. Dev Biol 2007;308:133-143 (Pubitemid 47096642)
7. Wohlgemuth SL, Crawford BD, Pilgrim DB. The myosin co-chaperone UNC-45 is required for skeletal and cardiac muscle function in zebrafish. Dev Biol 2007;303:483-492
8. Hoppe T, Cassata G, Barral JM, et al. Regulation of the myosin-directed chaperone UNC-45 by a novel E3/E4-multiubiquitylation complex in C. elegans. Cell 2004;118:337-349 (Pubitemid 39061114)
9. Landsverk ML, Li S, Hutagalung AH, et al. The UNC-45 chaperone mediates sarcomere assembly through myosin degradation in Caenorhabditis elegans. J Cell Biol 2007;177:205-210 (Pubitemid 46658632)
10. Chadli A, Felts SJ, Toft DO. GCUNC45 is the first Hsp90 co-chaperone to show α/β isoform specificity. J Biol Chem 2008;283:9509-9512
11. Chadli A, Graham JD, Abel MG, et al. GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway. Mol Cell Biol 2006;26:1722-1730 (Pubitemid 43297404)
12. Bazzaro M, Santillan A, Lin Z, et al. Myosin II co-chaperone general cell UNC-45 overexpression is associated with ovarian cancer, rapid proliferation, and motility. Am J Pathol 2007;171:1640-1649 (Pubitemid 350158324)
13. Minucci S, Pelicci PG. Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nat Rev Cancer 2006;6:38-51. (Pubitemid 43054973)
14. Epping MT, Wang L, Plumb JA, et al. A functional genetic screen identifies retinoic acid signaling as a target of histone deacetylase inhibitors. Proc Natl Acad Sci U S A 2007;104:17777-17782 (Pubitemid 350210911)
15. Epping MT, Bernards R. Molecular basis of the anti-cancer effects of histone deacetylase inhibitors. Int J Biochem Cell Biol 2009;41:16-20.
16. Epping MT, Wang L, Edel MJ, Carlee L, Hernandez M, Bernards R. The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling. Cell 2005;122:835-847 (Pubitemid 41345202)
17. Heery DM, Kalkhoven E, Hoare S, Parker MG. A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature 1997;387:733-736 (Pubitemid 27270617)
18. Torchia J, Rose DW, Inostroza J, et al. The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature 1997;387:677-684 (Pubitemid 27270601)
19. Reynolds CP, Schindler PF, Jones DM, Gentile JL, Proffitt RT, Einhorn PA. Comparison of 13-cis-retinoic acid to trans-retinoic acid using human neuroblastoma cell lines. Prog Clin Biol Res 1994;385:237-244
20. Sidell N, Altman A, Haussler MR, Seeger RC. Effects of retinoic acid (RA) on the growth and phenotypic expression of several human neuroblastoma cell lines. Exp Cell Res 1983;148:21-30. (Pubitemid 14231413)
21. Reynolds CP, Matthay KK, Villablanca JG, Maurer BJ. Retinoid therapy of high-risk neuroblastoma. Cancer Lett 2003;197:185-192
22. Matthay KK, Villablanca JG, Seeger RC, et al, Children's Cancer Group. Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid. N Engl J Med 1999;341:1165-1173
23. Esposito CL, D'Alessio A, de Franciscis V, Cerchia L. A cross-talk between TrkB and Ret tyrosine kinases receptors mediates neuroblastoma cells differentiation. PLoS ONE 2008;3:e1643. (Pubitemid 351865463)
24. Kaplan DR, Matsumoto K, Lucarelli E, Thiele CJ, Eukaryotic Signal Transduction Group. Induction of TrkB by retinoic acid mediates biologic responsiveness to BDNF and differentiation of human neuroblastoma cells. Neuron 1993;11:321-331
25. Peterson S, Bogenmann E. The RET and TRKA pathways collaborate to regulate neuroblastoma differentiation. Oncogene 2004;23:213-225 (Pubitemid 38142255)
26. Coffey DC, Kutko MC, Glick RD, et al. The histone deacetylase inhibitor, CBHA, inhibits growth of human neuroblastoma xenografts in vivo, alone and synergistically with all-trans retinoic acid. Cancer Res 2001;61:3591-3594
27. Wang XF, Qian DZ, Ren M, et al. Epigenetic modulation of retinoic acid receptor β2 by the histone deacetylase inhibitor MS-275 in human renal cell carcinoma. Clin Cancer Res 2005;11:3535-3542 (Pubitemid 40627909)
28. Kortlever RM, Higgins PJ, Bernards R. Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence. Nat Cell Biol 2006;8:877-884 (Pubitemid 44151592)
29. de Boer E, Rodriguez P, Bonte E, et al. Efficient biotinylation and single-step purification of tagged transcription factors in mammalian cells and transgenic mice. Proc Natl Acad Sci U S A 2003;100:7480-7485 (Pubitemid 36759995)