Computational modeling of cell growth heterogeneity in a perfused 3D scaffold

Industrial and Engineering Chemistry Research

Volumn 49, Issue 2, 2010, Pages 859-869

  Flaibani, Marina ^a   Magrofuoco, Enrico ^a   Elvassore, Nicola ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

3D SCAFFOLDS; APRIORI; CELL VOLUME; CELL VOLUME FRACTION; CHANNEL DIAMETERS; CHANNEL WALL; COMPUTATIONAL MODEL; COMPUTATIONAL MODELING; CYLINDRICAL CHANNEL; DIAMETER CHANNELS; DIAMETER DISTRIBUTIONS; EFFECTIVE DIAMETER; MASS BALANCE; MASS TRANSPORT; METABOLITE CONCENTRATIONS; MODEL SIMULATION; OPERATIONAL PARAMETERS; PERFUSION BIOREACTOR; SMALL DIAMETER CHANNELS; SPATIOTEMPORAL EVOLUTION; THREE-DIMENSIONAL POROUS SCAFFOLDS; TIME VARIATIONS;

BIOMOLECULES; FUNCTIONS; GROWTH KINETICS; MATHEMATICAL MODELS; METABOLISM; METABOLITES; PORE SIZE; SCAFFOLDS; SHEAR STRESS; STRENGTH OF MATERIALS; THREE DIMENSIONAL;

CELL GROWTH;

EID: 75249104609     PISSN: 08885885     EISSN: None     Source Type: Journal    
DOI: 10.1021/ie900418g     Document Type: Article

References (46)

1. Scadden, D. T. The stem-cell niche as an entity of action. Nature 2006, 441, 1075-79.
2. Khetani, S. R.; Bhatia, S. N. Engineering tissues for in vitro applications. Curr. Opin. Biotechnol. 2006, 17, 524-531.
3. Anon. Goodbye, flat biology? Nature 2003, 424, 861.
4. Smalley, K. S. M.; Lioni, M.; Herlyn, M. Life isn't flat: Taking cancer biology to the next dimension. In Vitro Cell, Dev. Biol. 2006, 42, 242-247.
5. O'Neill, A.; Schaffer, D. V. The biology and engineering of stem-cell control. Biotechnol. Appl. Biochem. 2004, 40, 5-16.
6. Li, L.; Xie, T. Stem cell niche: structure and function. Annu. Rev. Cell Dev. Biol. 2005, 21, 605-631.
7. Patel, M.; Fisher, J. P. Biomaterial scaffolds in pediatric tissue engineering. Pediatr. Res. 2008, 63, 497-501.
8. Eisenbarth, E. Biomaterials for tissue engineering. Adv. Eng. Mater. 2007, 9, 1051-1060.
9. Martin, Y.; Vermette, P. Bioreactors for tissue mass culture: Design, characterization, and recent advances. Biomaterials 2005, 26, 7481-7503.
10. Porter, B.; Zauel, R.; Stockman, H.; Guldberg, R.; Fyhrie, D. 3-D computational modeling of media flow through scaffolds in a perfusion bioreactor. J. Biomechanics 2005, 38,7.
11. Cimetta, E.; Flaibani, M.; Mella, M.; Serena, E.; Boldrin, L.; DeCoppi, P.; Elvassore, N. Enhancement of viability of muscle precursor cells on 3D scaffold in a perfusion bioreactor. Int. J. Artif. Organs 2007, 30, 415-428.
12. King, J.; Miller, W. Bioreactor development for stem cell expansion and controlled differentiation. Curr. Opin. Chem. Biol. 2007, 11,5.
13. Sengers, B. G.; Taylor, M.; Please, C. P.; Oreffo, R. O. C. Computational modelling of cell spreading and tissue regeneration in porous scaffolds. Biomaterials 2007, 28, 1926-1940.
14. Dunn, J. C. Y.; Chan, W.-Y.; Cristini, V.; Kim, J. S.; Lowengrub, J.; Singh, S.; Wu, B. M. Analysis of cell growth in three-dimensional scaffolds. Tissue Eng. 2006, 12, 705-716.
15. Coletti, F.; Macchietto, S.; Elvassore, N. Mathematical modeling of three-dimensional cell cultures in perfusion bioreactors. Ind. Eng. Chem. Res. 2006, 45, 8158-8169.
16. Dulong, J.-L.; Legallais, C. A theoretical study of oxygen transfer including cell necrosis for the design of a bioartificial pancreas. Biotechnol. Bioeng. 2007, 96, 990-998.
17. Gross, J. D.; Constantinidis, I.; Sambanis, A. Modeling of encapsulated cell systems. J. Theor. Biol. 2007, 244, 500-510.
18. Radisic, M.; Malda, J.; Epping, E.; Geng, W.; Langer, R.; Vunjak-Novakovic, G. Oxygen gradients correlate with cell density and cell viability in engineered cardiac tissue. Biotechnol. Bioeng. 2006, 93, 332-343.
19. Ye, H.; Das, D. B.; Triffitt, J. T.; Cui, Z. Modelling nutrient transport in hollow fibre membrane bioreactors for growing three-dimensional bone tissue. J. Membr. Sci. 2006, 272, 169-178.
20. Cioffi, M.; Boschetti, F.; Raimondi, M. T.; Dubini, G. Modeling evaluation of the fluid-dynamic microenvironment in tissue-engineered constructs: A micro-CT based model. Biotechnol. Bioeng. 2006, 93, 500-510.
21. Sawyer, N.; Worrall, L.; Crowe, J.; Waters, S.; Shakesheff, K.; Rose, F.; Morgan, S. In situ monitoring of 3D in vitro cell aggregation using an optical imaging system. Biotechnol. Bioeng. 2008, 100, 159-167.
22. Thelwall, P.; Neves, A.; Brindle, K. Measurement of bioreactor perfusion using dynamic contrast agent-enhanced magnetic resonance imaging. liwtechinooLJiwenig. 2001, 75, 682-690.
23. Lee, K.-M.; Gilmore, D. F. Statistical experimental design for bioprocess modeling and optimization analysis: repeated-measures method for dynamic biotechnology process. Appl. Biochem. Biotechnol. 2006, 135, 101-115.
24. Radisic, M.; Deen, W.; Langer, R.; Vunjak-Novakovic, G. Math-ematical model of oxygen distribution in engineered cardiac tissue with parallel channel array perfused with culture medium containing oxygen carriers. Am. J. Physiol. Heart Circ. Physiol. 2005, 288, H1278-H1289.
25. Galbusera, F.; Cioffi, M.; Raimondi, M. An in silico bioreactor for simulating laboratory experiments in tissue engineering. Biomed. Microde-vices 2008, 10, 547-554.
26. Galbusera, F.; Cioffi, M.; Raimondi, M.; Pietrabissa, R. Computational modeling of combined cell population dynamics and oxygen transport in engineered tissue subject to interstitial perfusion. Commit. Methods Biomechanics Biomed. Eng. 2007, 10, 279-287.
27. Lewis, M.; MacArthur, B.; Malda, J.; Pettet, G.; Please, C. Heterogeneous proliferation within engineered cartilaginous tissue: the role of oxygen tension. Biotechnol. Bioeng. 2005, 91, 607-615.
28. Mollet, M.; Godoy-Silva, R.; Berdugo, C.; Chalmers, J. Acute hydrodynamic forces and apoptosis: A complex question. Biotechnol. Bioeng. 2007, 98, 772-788.
29. Hathcock, J.; Hall, C.; Turitto, V. Active tissue factor shed from human arterial smooth muscle cells adheres to artificial surfaces. J. Biomater. Sci. 2000, 11, 1211-1225.
30. Bird, R.; Stewart, W.; Lightfoot, E. Transport Phenomena; John Wiley and Sons, Inc.: New York, 2002.
31. Obradovic, B.; Meldon, J. H.; Freed, L. E.; Vunjak-Novakovic, G. Glycosaminoglycan deposition in engineered cartilage: Experiments and mathematical model. AIChE J. 2000, 46, 1860-1871.
32. Galban, C. J.; Locke, B. R. Effects of spatial variation of cells and nutrient and product concentrations coupled with product inhibition on cell growth in a polymer scaffold. Biotechnol. Bioeng. 1999, 64, 633-643.
33. Galban, C. J.; Locke, B. R. Analysis of cell growth kinetics and substrate diffusion in a polymer scaffold. Biotechnol. Bioeng. 1999, 65, 121-132.
34. Acevedo, C. A.; Weinstein-Oppenheimer, C.; Brown, D. I.; Huebner, H.; Buchholz, R.; Young, M. E. A mathematical model for the design of fibrin microcapsules with skin cells. Bioprocess Biosyst. Eng. 2009, 32, 341-351.
35. Perry, R.; Green, D. Perry's Chemical Engineers' Handbook; McGraw-Hill: New York, 1997.
36. Crank, J. Free and Moving Boundary; Clarendon Press: Oxford, 1984.
37. van Lenthe, G. H.; Hagenmuller, H.; Bohner, M.; Hollister, S. J.; Meinel, L.; Muller, R. Nondestructive micro-computed tomography for biological imaging and quantification of scaffold-bone interaction in vivo. Biomaterials 2007, 28, 12.
38. Freed, L. E.; Guilak, F.; Guo, X. E.; Gray, M. L.; Tranquillo, R.; Holmes, J. W.; Radisic, M.; Sefton, M. V.; Kaplan, D.; Vunjak-Novakovic, G. Advanced tools for tissue engineering: Scaffolds, bioreactors, and signaling. Tissue Eng. 2006, 12, 3285-3305.
39. Tanaka, Y.; Yamato, M.; Okano, T.; Kitamori, T.; Sato, K. Evaluation of effects of shear stress on hepatocytes by a microchip-based system. Meas. Sci. Technol. 2006, 17,4.
40. MacPherson, J.; O'Hare, D.; Unwin, P.; Winlove, C. Quantitative spatially resolved measurements of mass transfer through laryngeal cartilage. Biophys. J. 1997, 73, 11.
41. Chow, D.; Wenning, L.; Miller, W.; Papoutsakis, E. Modeling pO2 distributions in the bone marrow hematopoietic compartment. I. Krogh's model. Biophys. J. 2001, 81, 10.
42. Zhao, F.; Pathi, P.; Grayson, W.; Xing, Q.; Locke, B. R.; Ma, T. Effects of oxygen transport on 3-D human mesenchymal stem cell metabolic activity in perfusion and static cultures: Experiments and mathematical model. Biotechnol. Prog. 2005, 21, 1269-1280.
43. Moreira, J.; Santana, P.; Feliciano, A.; Cruz, P.; Racher, A.; Griffiths, J.; Carrondo, M. Effect of viscosity upon hydrodynamically controlled natural aggregates of animal cells grown in stirred vessels. Biotechnol. Prog. 1995, 11,9.
44. Mehta, G.; Mehta, K.; Sud, D.; Song, J. W.; Bersano-Begey, T.; Futai, N.; Heo, Y. S.; Mycek, M.-A.; Linderman, J. J.; Takayama, S. Quantitative measurement and control of oxygen levels in microfluidic poly(dimethylsiloxane) bioreactors during cell culture. Biomed. Microdevices 2007, 9, 123-134.
45. Keane, J.; Ryan, D.; Gray, P. Effect of shear stress on expression of a recombinant protein by Chinese hamster ovary cells. Biotechnol. Bioeng. 2002, 81, 10.
46. Akimoto, S.; Mitsumata, M.; Sasaguri, T.; Yoshida, Y. Laminar shear stress inhibits vascular endothelial cell proliferation by inducing cyclin-dependent kinase inhibitor p21(Sdi1/Cip1/Waf1). Circ. Res. 2000, 86, 185-190.